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Surgical removal of the tonsils and appendix associated with risk of early heart attack
Date:5/31/2011

The surgical removal of the appendix and tonsils before the age of 20 was associated with an increased risk of premature heart attack in a large population study performed in Sweden.(1) Tonsillectomy increased the risk by 44% (hazard ratio 1.44) and appendectomy by 33% (HR 1.33). The risk increases were just statistically significant, and were even higher when the tonsils and appendix were both removed. However, there was no risk association evident when the operations were performed in people over the age of 20.

Both the appendix and tonsils are lymphoid organs and thus components of the body's immune system, albeit of modest importance. The recurrence of tonsillitis and appendicitis - caused by infection - are the usual reasons for removal. Behind the study lay evidence that removal was associated with moderate long-term effects on the immune system and alterations in risk for some autoimmune disorders. Studies suggest that between 10 and 20% of all young people have tonsils or appendix removed.

"Given the strong biological and epidemiological evidence linking inflammation with coronary heart disease," said investigator Dr Imre Janszky from the Department of Public Health Science of the Karolinska Institute in Stockholm, "one might anticipate that surgical removal of the tonsils and appendix, with their consequent effects on immunity, might also have a long-term effect on CHD. However, we were aware of no studies evaluating the potential effects of appendectomy or tonsillectomy on atherosclerosis or CHD risk."

The study, published online today in the European Heart Journal, examined the national health records of every Swedish resident born between 1955 and 1970 and identified each one who had had tonsils and/or appendix removed. Each of these "cases" was then matched with five randomly chosen "controls" who had not had the operations. These subjects were then followed up through the health records for an average of 23.5 year
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Contact: Jacqueline Partarrieu
press@escardio.org
33-492-947-756
European Society of Cardiology
Source:Eurekalert

Page: 1 2 3

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