Navigation Links
Surgical removal of abdominal fat reduces skin cancer in mice
Date:5/21/2012

Is it possible that liposuction or other fat removal procedures are beneficial for treating obesity and reducing the risk of cancer?

When it comes to humans, scientists can't answer that question. They know that obesity increases the risk of heart disease, diabetes and cancer. But there have not been clinical studies to determine if the surgical removal of fat tissue would decrease cancer risk in humans.

In animal studies, however, Rutgers scientists, who have published new research today online in the Proceedings of the National Academy of Sciences, have found that surgical removal of abdominal fat from mice fed a high-fat diet reduces the risk of ultraviolet-light induced skin cancer the most prevalent cancer in the United States with more than 2 million new cases each year.

"We don't know what effect fat removal would have in humans," said Allan Conney, professor of Pharmacology and director of the Susan Lehman Cullman Laboratory for Cancer Research at the Ernest Mario School of Pharmacy. "We would like to encourage epidemiologists to study whether there is a lower incidence of sunlight-induced skin cancer in people who have had liposuction surgery to remove fat tissue."

For more than a decade, Conney and his colleague Yao-Ping Lu have been studying how caffeine and exercise, which also decrease tissue fat, work to block UV-induced skin cancer. Despite the multiple human epidemiological studies that link coffee intake to a decrease in nonmelanoma skin cancer risk, just how and why coffee protects against the disease is still unknown.

In this new skin cancer study, Rutgers researchers found that surgical removal of abdominal fat from obese mice fed a high-fat diet had between 75-80 percent fewer UV-induced skin cancers than mice that did not undergo fat-removal surgery.

Although scientists understand that tissue fat may play a role in tumor formation, there has been little research on the molecular mechanisms of how a high-fat diet increases the formation of skin cancer. This new study suggests that abdominal fat in mice secretes proteins that enhance the risk of cancer. Once the original fat tissue is removed, the biochemical properties of new fat tissue that appear after surgery are less harmful.

While it is well known that decreased calorie-intake, low-fat diets and physical exercise is recommended for treating obesity, preventing cancer by surgically removing tissue fat still needs to be explored.

"It would be interesting to see if surgical removal of fat tissue in animals would prevent obesity-associated lethal cancers like those of the pancreas, colon and prostate," Conney said. "Whether removal of tissue fat in humans -- which has certain risks -- would decrease the risk of life-threatening cancers in humans is not known."


'/>"/>
Contact: Robin Lally
rlally@ur.rutgers.edu
732-932-7084 x652
Rutgers University
Source:Eurekalert

Related medicine news :

1. 2010 HSR Impact Award recognizes surgical safety research
2. Annals of Surgical Oncology adds new society affiliation
3. Medicare data reveals differences in orthopedic surgical outcomes
4. Is a Tummy Tuck Right for Me? Alabama Plastic Surgeon Dr. David Durst Offers Tips as the Popularity of Surgical Cosmetic Enhancement Continues to Rise
5. Two Surgical Methods Equally Successful for Prostate Cancer
6. Surgical Information Systems Introduces SIS OR View to Maximize Communication and Improve Patient Safety in the Operating Room
7. Delaying post-surgical radiation increases risk of breast cancer recurrence in older women
8. Florida Surgeon Demonstrates Kidney Sparing Cancer Treatment in Live Surgical Webcast
9. National Institutes of Health Awards Kitware Over $600,000 to Develop Advancements in Neurosurgical Simulation
10. Medical Ultrasound Now Used in New, Non-surgical Cosmetic Procedure
11. Eisner USA, LLC Collaborates with Surgical Review Corp to Provide Innovative Bariatric Devices to Bariatric Surgery Center of Excellence (BSCOE) Participants
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/26/2017)... (PRWEB) , ... May 26, 2017 , ... Mediaplanet is ... Wound Care" campaign in USA Today, which will educate readers on how to take ... the campaign, a large focus is placed on melanoma. Dancing with the Stars professional, ...
(Date:5/26/2017)... Clara, Calif. (PRWEB) , ... May 26, 2017 ... ... announces the integration of the CareFusion NOX-T3 portable sleep monitor with its Somnoware ... provides a consistent, browser-based interface for diagnostic device operations. With this platform, initializing ...
(Date:5/26/2017)... , ... May 26, 2017 , ... After raising nearly ... Top gadget will continue to be available at a discounted crowdfunding price on ... stress wherever they are, I also wanted to bring a fidget toy to the ...
(Date:5/26/2017)... , ... May 26, 2017 , ... “When the Stars ... Home” is the creation of published author Laura Weigel Douglas, an avid reader who ... in a house that sometimes feels like Green Hills Adventure Camp. She couldn’t be ...
(Date:5/26/2017)... ... , ... Water damage to the flooring of several classrooms at The Fort ... with a number of critical issues to address before students could return to classes. ... little or no disruption to class schedules. Second, the project had to comply with ...
Breaking Medicine News(10 mins):
(Date:5/11/2017)... 11, 2017  Thornhill Research Inc. ( ... an $8,049,024 USD five-year, firm-fixed-priced, indefinite-quantity/indefinite-delivery contract by ... Commercial Corporation (CCC) ( Ottawa, Ontario, Canada ... administer general anesthesia to patients requiring emergency medical ... US Marine Corps have been a longtime partner ...
(Date:5/10/2017)... , May 10, 2017 Radiology has become ... its costs have also spiraled to the number one ... to radiology than ever before as the most complete ... a patient with lower back pain an MRI may ... reason for pain, resulting in entirely different treatment protocols.  ...
(Date:5/9/2017)... , May 9, 2017  Oramed Pharmaceuticals Inc. ... a clinical-stage pharmaceutical company focused on the development ... the Canadian Intellectual Property Office has granted Oramed ... Administration of Exenatide". The patent covers Oramed,s invention ... GLP-1 is an incretin hormone that stimulates ...
Breaking Medicine Technology: