Navigation Links
Surgical removal of abdominal fat reduces skin cancer in mice
Date:5/21/2012

Is it possible that liposuction or other fat removal procedures are beneficial for treating obesity and reducing the risk of cancer?

When it comes to humans, scientists can't answer that question. They know that obesity increases the risk of heart disease, diabetes and cancer. But there have not been clinical studies to determine if the surgical removal of fat tissue would decrease cancer risk in humans.

In animal studies, however, Rutgers scientists, who have published new research today online in the Proceedings of the National Academy of Sciences, have found that surgical removal of abdominal fat from mice fed a high-fat diet reduces the risk of ultraviolet-light induced skin cancer the most prevalent cancer in the United States with more than 2 million new cases each year.

"We don't know what effect fat removal would have in humans," said Allan Conney, professor of Pharmacology and director of the Susan Lehman Cullman Laboratory for Cancer Research at the Ernest Mario School of Pharmacy. "We would like to encourage epidemiologists to study whether there is a lower incidence of sunlight-induced skin cancer in people who have had liposuction surgery to remove fat tissue."

For more than a decade, Conney and his colleague Yao-Ping Lu have been studying how caffeine and exercise, which also decrease tissue fat, work to block UV-induced skin cancer. Despite the multiple human epidemiological studies that link coffee intake to a decrease in nonmelanoma skin cancer risk, just how and why coffee protects against the disease is still unknown.

In this new skin cancer study, Rutgers researchers found that surgical removal of abdominal fat from obese mice fed a high-fat diet had between 75-80 percent fewer UV-induced skin cancers than mice that did not undergo fat-removal surgery.

Although scientists understand that tissue fat may play a role in tumor formation, there has been little research on the molecular mechanisms of how a high-fat diet increases the formation of skin cancer. This new study suggests that abdominal fat in mice secretes proteins that enhance the risk of cancer. Once the original fat tissue is removed, the biochemical properties of new fat tissue that appear after surgery are less harmful.

While it is well known that decreased calorie-intake, low-fat diets and physical exercise is recommended for treating obesity, preventing cancer by surgically removing tissue fat still needs to be explored.

"It would be interesting to see if surgical removal of fat tissue in animals would prevent obesity-associated lethal cancers like those of the pancreas, colon and prostate," Conney said. "Whether removal of tissue fat in humans -- which has certain risks -- would decrease the risk of life-threatening cancers in humans is not known."


'/>"/>
Contact: Robin Lally
rlally@ur.rutgers.edu
732-932-7084 x652
Rutgers University
Source:Eurekalert

Related medicine news :

1. 2010 HSR Impact Award recognizes surgical safety research
2. Annals of Surgical Oncology adds new society affiliation
3. Medicare data reveals differences in orthopedic surgical outcomes
4. Is a Tummy Tuck Right for Me? Alabama Plastic Surgeon Dr. David Durst Offers Tips as the Popularity of Surgical Cosmetic Enhancement Continues to Rise
5. Two Surgical Methods Equally Successful for Prostate Cancer
6. Surgical Information Systems Introduces SIS OR View to Maximize Communication and Improve Patient Safety in the Operating Room
7. Delaying post-surgical radiation increases risk of breast cancer recurrence in older women
8. Florida Surgeon Demonstrates Kidney Sparing Cancer Treatment in Live Surgical Webcast
9. National Institutes of Health Awards Kitware Over $600,000 to Develop Advancements in Neurosurgical Simulation
10. Medical Ultrasound Now Used in New, Non-surgical Cosmetic Procedure
11. Eisner USA, LLC Collaborates with Surgical Review Corp to Provide Innovative Bariatric Devices to Bariatric Surgery Center of Excellence (BSCOE) Participants
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/27/2016)... Viejo, California (PRWEB) , ... June 27, 2016 , ... ... are fully customizable inside of Final Cut Pro X," said Christina Austin - CEO ... another unique style. Final Cut Pro X users can now reveal the ...
(Date:6/27/2016)... ... June 27, 2016 , ... ... technology to revolutionize the emergency ambulance transport experience for the millions of people ... how Uber has disrupted the taxi industry through the use of technology. Now, ...
(Date:6/26/2016)... ... , ... On June 10-11, 2016, A Forever Recovery, a holistic treatment center ... Breakfast Table in Battle Creek, MI, where the rehabilitation facility is located. This annual ... the world’s leading providers of cereal and other breakfast foods. Its residents often refer ...
(Date:6/26/2016)... ... , ... Brent Kasmer, a legally blind and certified personal trainer is helping to develop a ... fitness app plans to fix the two major problems leading the fitness industry today:, ... type program , They don’t eliminate all the reasons people quit their exercise ...
(Date:6/25/2016)... , ... June 25, 2016 , ... Austin residents seeking ... American College of Mohs Surgery and to Dr. Russell Peckham for medical and surgical ... effective treatment for skin cancer. The selective fellowship in Mohs Micrographic Surgery completed by ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... --  Pulmatrix, Inc ., (NASDAQ: PULM ), ... today that it was added to the Russell Microcap ... set of U.S. and global equity indexes on June ... for Pulmatrix," said Chief Executive Officer Robert Clarke ... in developing drugs for crucial unmet medical needs, and ...
(Date:6/23/2016)... Research and Markets has announced the addition of ... report to their offering. ... kidney failure, it replaces the function of kidneys by removing ... thus the treatment helps to keep the patient body,s electrolytes ... Increasing number of ESRD patients & substantial healthcare expenditure ...
(Date:6/23/2016)... , June 23, 2016 Roche (SIX: RO, ... clearance for its Elecsys BRAHMS PCT (procalcitonin) assay as ... or septic shock. With this clearance, Roche is the ... fully integrated solution for sepsis risk assessment and management. ... bacterial infection and PCT levels in blood can aid ...
Breaking Medicine Technology: