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Surface Logix Raises $20 Million in Financing and Starts Phase 2b Clinical Trial of SLx-4090 in Dyslipidemia and Diabetes
Date:3/9/2009

he safety, tolerability and clinical utility of SLx-4090 in a range of patients with metabolic and lipid disorders."

About SLx-4090 in Dyslipidemia, Diabetes and Obesity

SLx-4090 is a novel, oral, non-systemically available inhibitor of microsomal triglyceride transfer protein (MTP) that acts by blocking the formation of particles known as chylomicrons in enterocytes, thereby reducing the uptake of triglycerides and cholesterol into the lymphatic circulation and ultimately, the systemic circulation. Designed to exert its effect only in enterocytes, SLx-4090 avoids mechanistic toxicities in the liver (where MTP inhibition causes fatty liver) and other organs. MTP inhibitors that have been brought into development by others lack this critical feature and have therefore encountered significant toxicity concerns in the clinic, which will severely limit their therapeutic potential. SLx-4090 has potential not only in dyslipidemia but also in obesity and diabetes as a result of the compound's ability to restrict energy absorption by reducing the uptake of triglycerides. SLx-4090 has demonstrated an excellent safety profile in both clinical and pre-clinical studies.

About Surface Logix Inc.

Surface Logix Inc. uses its expertise in biophysical chemistry to create and develop novel small molecule drugs to treat metabolic and cardiovascular disease. For more information, please visit http://www.surfacelogix.com.

    Contact:

    Warwick Tong, MD
    Surface Logix Inc.
    Sr. Vice President, Corporate Development
    617.746.8505

    Media:
    Sarah Cavanaugh
    MacDougall Biomedical Communications Inc.
    781.235.3060


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SOURCE Surface Logix Inc.
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