Navigation Links
Surface Logix Raises $20 Million in Financing and Starts Phase 2b Clinical Trial of SLx-4090 in Dyslipidemia and Diabetes
Date:3/9/2009

BOSTON, March 9 /PRNewswire/ -- Surface Logix today announced that it has raised over $20 million in a combined equity and debt financing. The Company raised approximately $15 million through equity contributions by existing investors, including ARCH Venture Partners, HBM BioVentures, Healthcare Focus, Intel Capital, Saudi Venture Development Company, Unilever Technology Ventures and Venrock Associates. In addition, MPM Capital participated as a new investor. On top of the equity round, $5 million was raised through a venture loan from Silicon Valley Bank.

"This significant financing with top-quality investors is a testament to the strength of our clinical pipeline of drug candidates and our discovery capabilities," said Dr. Keith Dionne, CEO of Surface Logix. "We will use these proceeds to advance our novel metabolic and cardiovascular programs:

  • Complete Phase 2b studies for SLx-4090 in dyslipidemia, diabetes and obesity;
  • Formulate SLx-2101, our novel PDE-5 inhibitor, in preparation for Phase 2b trials in hypertension;
  • Complete first-in-human studies for SLx-2119, the lead compound in our selective ROCK inhibitor program; and
  • Advance two or more of our novel enteric discovery programs, targeting metabolic disorders, into development."

The Company also announced the start of a U.S.-based multicenter Phase 2b clinical trial to test the lipid-lowering effects of SLx-4090 in 135 patients with dyslipidemia. This three-month trial in overweight and obese patients will also study the effects of SLx-4090 on markers of diabetes and metabolic syndrome.

"We are excited to be moving into the next important phase in the clinical development of SLx-4090," commented Dr Warwick Tong, SVP of Development at Surface Logix. "This is the first of two complementary trials in dyslipidemia and diabetes that will study the safety, tolerability and clinical utility of SLx-4090 in a range of patients with metabolic and lipid disorders."

About SLx-4090 in Dyslipidemia, Diabetes and Obesity

SLx-4090 is a novel, oral, non-systemically available inhibitor of microsomal triglyceride transfer protein (MTP) that acts by blocking the formation of particles known as chylomicrons in enterocytes, thereby reducing the uptake of triglycerides and cholesterol into the lymphatic circulation and ultimately, the systemic circulation. Designed to exert its effect only in enterocytes, SLx-4090 avoids mechanistic toxicities in the liver (where MTP inhibition causes fatty liver) and other organs. MTP inhibitors that have been brought into development by others lack this critical feature and have therefore encountered significant toxicity concerns in the clinic, which will severely limit their therapeutic potential. SLx-4090 has potential not only in dyslipidemia but also in obesity and diabetes as a result of the compound's ability to restrict energy absorption by reducing the uptake of triglycerides. SLx-4090 has demonstrated an excellent safety profile in both clinical and pre-clinical studies.

About Surface Logix Inc.

Surface Logix Inc. uses its expertise in biophysical chemistry to create and develop novel small molecule drugs to treat metabolic and cardiovascular disease. For more information, please visit http://www.surfacelogix.com.

    Contact:

    Warwick Tong, MD
    Surface Logix Inc.
    Sr. Vice President, Corporate Development
    617.746.8505

    Media:
    Sarah Cavanaugh
    MacDougall Biomedical Communications Inc.
    781.235.3060


'/>"/>
SOURCE Surface Logix Inc.
Copyright©2009 PR Newswire.
All rights reserved

Related medicine news :

1. FDA Clears New Skin and Surface Treatment Applicator for Use With Xofts Axxent(R) Electronic Brachytherapy (eBx) System
2. Study suggests surface water contaminated with salmonella more common than thought
3. Alternative Surface Disinfection Explored in Latest Issue of American Journal of Infection Control (AJIC)
4. Cradle to Cradle(SM) Digs Beneath the Surface with New Ingredient Certification
5. E6 Ventures Invests in Novel Coatings Developer, Diamond Hard Surfaces Ltd
6. Hill-Rom Announces Agreement with Encompass Therapeutic Support Systems Adding New Surface Choice for Use with Hill-Rom Frames
7. Particle Sciences Develops Methods for Increasing Quality of Sintered Metal Products and for Coating Surfaces with Metal Oxide Films
8. Arthrosurface HemiCAP(R) Focal Knee Resurfacing Implant Receives FDA Approval to Move into Final Investigational Stage
9. GOCE Earth explorer satellite to look at the Earths surface and core
10. Measurement technique probes surface structure of gold nanocrystals
11. Large source of nitrate, a potential water contaminant, found in near-surface desert soils
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/18/2017)... (PRWEB) , ... February 18, 2017 , ... ... today provides the latest information and contact points to easily connect elderly veterans ... care, assisted living, and elder-care funding. It also conveys material on this year's ...
(Date:2/17/2017)... ... February 17, 2017 , ... While EHR data ... has introduced an innovative workstation designed to reduce nursing fatigue while enhancing productivity. ... EHR Workstation offers a lightweight, highly mobile, multi-functional alternative to the limitations of ...
(Date:2/17/2017)... ... February 17, 2017 , ... Wells Pharmacy Network offers physicians ... controlled and non-controlled substances plus the ability to manage orders on their desktop ... now accept electronic prescriptions, according to the Office of the National Coordinator of ...
(Date:2/17/2017)... (PRWEB) , ... February 17, ... ... Device Approval and Reimbursement , **An FDAnews Webinar**, Feb. 22, 2017 — ... are the critical reimbursement questions manufacturers should be asking before selecting an ...
(Date:2/17/2017)... , ... February 17, 2017 , ... ... to Prevent a Warning Letter, **An FDAnews Webinar**, Feb. 23, 2017 — 1:30 ... manufacturers distinguish between corrective action (CA) and preventive action (PA)? , The methods ...
Breaking Medicine News(10 mins):
(Date:2/20/2017)... YORK , Feb. 20, 2017  This report analyzes the ... Million. The report provides separate comprehensive analytics for the US, ... Europe , Asia-Pacific , ... Read the full report: http://www.reportlinker.com/p04707127-summary/view-report.html ... period 2015 through 2022. Also, a six-year historic analysis is ...
(Date:2/20/2017)... 20, 2017  National Decision Support Company (NDSC) ... company,s CareSelect Imaging platform within the full range ... the technical foundation for MEDITECH sites, through a ... Clinical Decision Support Mechanism through the MEDITECH EHR. ... and support the integration of NDSC,s mechanism, which ...
(Date:2/20/2017)... Feb. 20, 2017   Orion Health ™ ... Amadeus precision medicine platform to the Amazon Web ... over 110 million patient records globally. "We ... big data solutions built on modern, scalable technology," said ... Life Sciences. "The AWS Cloud gives healthcare companies a ...
Breaking Medicine Technology: