Navigation Links
Supportive tissue in tumors hinders, rather than helps, pancreatic cancer
Date:5/22/2014

"But it's not just a negative study, because it suggests what might work for these patients."

And what might work hinges on immune checkpoint blockade.

The immune system connection

To understand the cause of the swift progression, the team conducted gene expression profiling and RNA sequence analysis comparing control tumors to myofibroblast-depleted tumors.

Genes associated with tumor immunity were suppressed and fewer T cells and B cells infiltrated the myofibroblast-depleted tumors. The proportion of regulatory T cells, which suppress immune response, increased. They found greater expression of the immune checkpoint CTLA-4, which shuts down immune response.

The researchers then set up a new experiment using ipilimumab, a drug developed by co-author Jim Allison, Ph.D., chair of Immunology, that blocks CTLA-4, freeing T cells to attack tumors.

Mice with depleted myofibroblasts who were treated with ipilimumab to stifle CTLA-4 had an average survival increase of 60% compared to untreated control mice and those with either depleted myofibroblasts or treated with ipilimumab alone.

These findings suggest that ipilimumab might work for patients with low levels of fibrosis in their tumors, Kalluri noted. Combining ipilimumab with a hedgehog inhibitor is likely to work better for those with high-fibrosis. The Kalluri laboratory is exploring these issues.


'/>"/>

Contact: Scott Merville
smerville@mdanderson.org
713-792-0661
University of Texas M. D. Anderson Cancer Center
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. International breast health global summit will focus on supportive care and quality of life
2. Supportive Spouse May Extend Cancer Survival
3. Churchview Supportive Living to Host Music Therapy Informational Program
4. Supportive role models, coping lead to better health in poor teens
5. Churchview Supportive Living to Host African American History Heritage Bowl
6. John Evans Supportive Living to Host Annual Carnival
7. John Evans Supportive Living Community to Host Flu Shot Clinic
8. SomaLogic publishes proteomic biomarker analysis of lung cancer tissue samples
9. Mechanical tissue resuscitation technology shows promise
10. Computing the best high-resolution 3-D tissue images
11. Genetic abnormalities in benign or malignant tissues predict relapse of prostate cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/19/2015)... (PRWEB) April 19, 2015 HealthPostures, LLC ... announces that it will exhibit it’s pioneering ergonomics products ... and the Iowa-Illinois Safety Council Professional Development Conference and ... the TaskMate EZ are used in volume by call ... , Built to clamp to a desk, the ...
(Date:4/18/2015)... Carinsurancequotesinfo.com has released a new blog post ... caused by a car accident. , Car ... vehicle. A policy can pay for car repairs and ... always carry appropriate coverage when they are driving. ... with several important riders that offer extra coverage options. ...
(Date:4/18/2015)... 18, 2015 "I wanted to ... create a healthful juice that contained essential vitamins, ... Md. "It increases my energy, improves skin elasticity ... He developed Tapp's Juice to contain fruits, vegetables ... prevent physical and mental fatigue. It features a ...
(Date:4/18/2015)... April 18, 2015 Lower-auto-insurance.com has released ... accurate auto insurance quotes . , Drivers ... by comparing quotes. A professional insurance brokerage website can ... quotes, in a simple, convenient way. The whole process ... anyone. , Comparing online car insurance quotes is ...
(Date:4/18/2015)... More than 2000 styles of newly designed ... #1 online store carrying celebrity inspired special occasion dresses. ... their perfect dresses for their prom. For those who ... at TheCelebrityDresses.com would be an ideal choice. , ... dresses inspired by the most loved styles seen at ...
Breaking Medicine News(10 mins):Health News:HealthPostures' TaskMate Products to be Exhibited at the Wisconsin and Iowa-Illinois Safety Conferences 2Health News:Auto Insurance Plans Can Cover Physical Injuries Caused By An Accident! 2Health News:Auto Insurance Quotes Can Provide Accurate Results! 2Health News:Prom Dresses 2015 on Sale at TheCelebrityDresses.com 2
... percent of the U.S. population. Nearly one-third of affected ... bowel movements do not work well. Those who suffer ... research shows biofeedback treatment can successfully retrain muscles. ... laxatives, diet and exercise or another treatment (sham) that ...
... use by young adults significantly boost their risk of stroke, ... to a research. ,In the study, available online in ... than 8,300 stroke patients – ranging in age from 18 ... years 2000 through 2003. ,An analysis of ...
... Psychiatry and Allied Science (RINPAS), one of India's premier mental ... services to reach out to more people. ... attached with the institute," RINPAS director P.K. Chakravarty said Thursday. ... well as hospital inmates. ,RINPAS was set up ...
... a medical care crisis as numbers of students studying geriatric ... of Cincinnati. ,It is estimated that by the ... over the age of 65 in the United States. ... the number of certified geriatricians in the United States has ...
... The amount of prostate-specific antigen (PSA) in a man’s ... or its rate of change over the course of ... according to a study in the April 4 Journal ... with untreated localized prostate cancer have high long-term survival ...
... common antiviral drugs during a recent influenza B epidemic ... resistance to the drugs//, according to a study. ... a type of drugs known as neuraminidase inhibitors, have ... has been documented evidence of the emergence of oseltamivir-resistant ...
Cached Medicine News:Health News:Biofeedback Treats One Type Of Chronic Constipation 2Health News:Biofeedback Treats One Type Of Chronic Constipation 3Health News:Amphetamine, Cocaine Use Increase Risk of Stroke in Young Adults 2Health News:Number of Students Taking Up Geriatric Medicine on the Decline 2Health News:PSA Not a Good Predictor of Lethal Prostate Cancer 2Health News:Study Suggests Some Drug Resistance to Influenza B Medications 2
(Date:4/17/2015)...  Regulatory leaders in the pharmaceutical industry continue to ... "21 st Century Cures." This ... by Congress soon and if enacted into law, it ... developed and marketed in the United States ... to consider how the proposed changes could impact their ...
(Date:4/17/2015)... 17, 2015 Nonin Medical, a global leader ... Chief Operating Officer Steve Bucholz will retire ... expanding his role as Chief Executive Officer. In addition, ... Technology Officer. Operations will transition to David Noel ... has been instrumental to Nonin Medical,s growth," Mr. ...
(Date:4/17/2015)... DUBLIN , Apr. 17, 2015 Research and ... addition of the "Medical Equipment Rental and Leasing ... offering. This report analyzes the worldwide markets ... The report provides separate comprehensive analytics for the US, ... , and Rest of World. Annual estimates ...
Breaking Medicine Technology:21st Century Cures: A Regulatory Game-Changer for the Pharmaceutical Industry 2Nonin Medical's Philip Isaacson Expands CEO Role; President and COO Steve Bucholz to Retire May 1 2Medical Equipment Rental and Leasing Market 2015-2020 - Global Strategic Business Report - Healthcare Spending Slowdown Bodes Well for Medical Equipment Leasing 2
... today launched a new program to help county residents deal ... with the National Association of Counties (NACo), the free Prescription ... offers an average of 24 percent savings off the retail ... be used by those who do not have insurance or ...
... Perrigo Company (Nasdaq: PRGO ; TASE) today ... quarter fiscal 2012 on Thursday, October 27, 2011 at approximately ... at 10:00 a.m. (ET) hosted by Joseph C. Papa, Perrigo,s ... will be available live via webcast to interested parties on ...
Cached Medicine Technology:Yamhill County Introduces Prescription Discount Card to Help Alleviate High Costs 2
... two plastic parts that clamp a corneal ... the patient's cornea like a standard graft. ... since the 1960s and has gradually been ... About 600 implantations have been performed. It ...
A comprehensive CPT surgical, radiological and anesthesia coding reference....
Provides quick access to information needed to make diagnoses and treatment decisions....
PDA application containing all 7,000+ Physicians' Current Procedural Terminology codes developed by the American Medical Association....
Medicine Products: