Navigation Links
Support cells, not neurons, lull the brain to sleep
Date:1/28/2009

n shown to influence behavior. Unlike neurons, astrocytes do not fire electrical spikes, and they are often described as support cells.

In experiments on mice, Dr. Halassa and his colleagues used a genetic switch, called the dnSNARE transgene, to block the release of adenosine and other chemicals from astrocytes. The researchers then deprived the mice of sleep for short periods, and evaluated them with behavioral tests and with electroencephalography (EEG), a means of recording brain activity.

Mice subjected to the genetic blockade exhibited less sleep pressure than control mice. Following sleep deprivation, they did not need as much compensatory sleep, and during the early phases of sleep, they had patterns of brain activity consistent with low sleep pressure. When they were evaluated with a memory test, they performed as if their sleep had been undisturbed.

The researchers observed similar results when they used certain compounds to block the effects of adenosine on neurons. Neurons have several types of cell-surface receptors that enable them to respond to adenosine, but only pharmacological blockade of the A1 type of receptor was effective. That result shows that adenosine acts through the A1 receptor to produce sleep pressure.

Taken together, the results hint at the possibility of new drugs that could increase or decrease sleep pressure as necessary. The best available sleep aids tend to be effective at inducing sleep, but not effective at keeping it steady throughout the night. Meanwhile, the most commonly used stimulant, caffeine, acts on multiple types of adenosine receptors, and can affect sleep patterns even when it is consumed in the morning. Drugs that target astrocytes or the A1 receptors on neurons might be more effective at fine-tuning the urge to sleep, the study authors say.

The dnSNARE mice also will prove useful for answering some long-standing questions about sleep, experts say. For instanc
'/>"/>

Contact: Daniel Stimson
stimsond@ninds.nih.gov
301-496-5751
NIH/National Institute of Neurological Disorders and Stroke
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Purkinje Announces EMR Promotions in Support of National Healthcare Reform Initiatives
2. Call- Shadow IP Call Management Software, V.5. Now 64 bit with SIP and Enhanced Platform Support
3. Manhattan Research Survey Finds That Physicians Overwhelmingly Support Commercially-Funded Continuing Medical Education
4. Lance Armstrong Foundation Selects Ogilvy Public Relations Worldwide to Support the LIVESTRONG Global Cancer Campaign
5. Impac Software Announces Clinical Release of RapidArc Support
6. Technology Leaders Call on Congress to Support Investments in Digital Infrastructure as Part of Economic Stimulus and Recovery Plan
7. Grassroots Group Gets Travel Advantage Network Support
8. Developing countries need support to ethically conduct unlinked anonymous HIV testing
9. The Quantum Group Announces Support of Technology Bill Before Congress
10. Seattle Reproductive Medicine Study Investigates Newly Formulated Medications for Luteal Support in IVF
11. National Council of Legislators From Gaming States Adopts Resolution Supporting 100% Smokefree Gaming Venues
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/20/2014)... 20, 2014 With a mere 19 ... Crist made a brief fundraising stop at the ... , Fresh from a debate last night with his ... stage for the first seven minutes because Crist had ... described the incident in one word: "weird." , Before ...
(Date:10/20/2014)... The Advocator Group, LLC is proud ... for Suicide Prevention’s (AFSP) Out of the Darkness walk ... that hosts hundreds of community walks throughout the country ... to help understand and prevent suicide through not only ... , The Advocator Group shares this passion for ...
(Date:10/20/2014)... (PRWEB) October 20, 2014 Women’s health ... in Obstetrics & Gynecology of Columbus, Inc., A Division ... healthcare services to more than 100,000 patients annually. Dr. ... all ages and stages of a women’s life. She ... locations in Westerville and Dublin. , Dr. Murphy ...
(Date:10/20/2014)... (PRWEB) October 20, 2014 hc1.com ... a secure cloud solution that enables healthcare organizations ... the ultimate healthcare-specific customer relationship management (“CRM”) solution. ... the unique needs of the healthcare industry, the ... for providers and patients by combining healthcare CRM, ...
(Date:10/20/2014)... Angeles, CA (PRWEB) October 20, 2014 ... fitness expertise, nutritional coaching, corporate wellness programming, authorship, international ... CPT, is excited to announce the release of the ... , After many years of coaching thousands of individuals ... nutrition tracking app that does not require calorie counting ...
Breaking Medicine News(10 mins):Health News:At Crist Fundraiser, Dan Newlin Says, "No More Robert Germans," Will Seek Changes to Florida Missing Persons Law 2Health News:At Crist Fundraiser, Dan Newlin Says, "No More Robert Germans," Will Seek Changes to Florida Missing Persons Law 3Health News:The Advocator Group, LLC is Proud to Participate in an Out of the Darkness Community Walk, October 25th, to Increase Suicide Awareness 2Health News:The Advocator Group, LLC is Proud to Participate in an Out of the Darkness Community Walk, October 25th, to Increase Suicide Awareness 3Health News:OhioHealth Welcomes New Women’s Health Specialist to MaternOhio Specialists in Obstetrics & Gynecology of Columbus, Inc. 2Health News:OhioHealth Welcomes New Women’s Health Specialist to MaternOhio Specialists in Obstetrics & Gynecology of Columbus, Inc. 3Health News:Healthcare Relationship Management (HRM) Leader hc1.com® Launches hc1® Quick Start™ 2Health News:JZ Fitness Nutrition App Launches on iTunes 2Health News:JZ Fitness Nutrition App Launches on iTunes 3
... March 19 Mirion Technologies, the,leading global provider ... protection industry, will showcase two new products at ... Beijing from,March 25th - 28th., Mirion,s Health ... Body Contamination Monitor. The TwoStep Exit monitor is ...
... March 19, 2008 Chronic fatigue syndrome ... debilitating diseases with no confirmed cause and limited ... literature study propose a simplified treatment process that ... these diseases. , Kent Holtorf, M.D., medical director ...
... SAN DIEGO, March 19 Cardium Therapeutics,(Amex: ... InnerCool Therapies announced today that,InnerCool has entered ... one of Australia,s leading medical device distributors ... agreement, Lifehealthcare will have,exclusive marketing, sales and ...
... March 19 Forest Laboratories, Inc.,(NYSE: FRX ) ... -,Scientific Affairs and President of the Forest Research Institute ... March 31, 2008., (Logo: http://www.newscom.com/cgi-bin/prnh/20001011/FORESTLOGO ), ... Officer of,Forest, stated: "The Board and I wish to ...
... Open Standard Data Management ... Systems for Company, ... of digital radiography (DR), PACS (Picture Archiving and,Communications System) and practice ... Dennis,Ballance, DVM, as division manager of the newly-formed Eklin Data Services,Division. ...
... Inc.,(Nasdaq: ABAX ), a medical products company ... Severson, CEO and,President, will present at Sidoti & ... Forum on Tuesday, March 25, 2008 at,11:00 a.m. ... Grand Hyatt in New York,City., About Abaxis, ...
Cached Medicine News:Health News:Mirion Technologies to Showcase New Product Offerings for the Nuclear Industry During 10th Annual China International Nuclear Industry Exhibition 2Health News:Data study suggests cortisol could alleviate for chronic fatigue syndrome and fibromyalgia 2Health News:Cardium's InnerCool Therapies Unit Announces Australian Distribution Agreement for CoolBlue and Rapid Blue Systems 2Health News:Cardium's InnerCool Therapies Unit Announces Australian Distribution Agreement for CoolBlue and Rapid Blue Systems 3Health News:Cardium's InnerCool Therapies Unit Announces Australian Distribution Agreement for CoolBlue and Rapid Blue Systems 4Health News:Cardium's InnerCool Therapies Unit Announces Australian Distribution Agreement for CoolBlue and Rapid Blue Systems 5Health News:Cardium's InnerCool Therapies Unit Announces Australian Distribution Agreement for CoolBlue and Rapid Blue Systems 6Health News:Cardium's InnerCool Therapies Unit Announces Australian Distribution Agreement for CoolBlue and Rapid Blue Systems 7Health News:Cardium's InnerCool Therapies Unit Announces Australian Distribution Agreement for CoolBlue and Rapid Blue Systems 8Health News:Cardium's InnerCool Therapies Unit Announces Australian Distribution Agreement for CoolBlue and Rapid Blue Systems 9Health News:Forest Laboratories Announces Resignation of Ivan Gergel, MD 2Health News:Eklin Medical Names Ballance Head of New Data Services Division 2Health News:Eklin Medical Names Ballance Head of New Data Services Division 3
(Date:10/22/2014)... 2014  CryoLife, Inc. (NYSE: CRY ), ... on cardiac and vascular surgery, announced today that ... Officer, has been elected to the Company,s Board of ... G. Anderson , Executive Chairman of CryoLife, stated, "Since joining ... an excellent leader who is well positioned to maximize ...
(Date:10/22/2014)... 2014 Oramed Pharmaceuticals Inc. ... pharmaceutical company focused on the development of oral ... results from its Phase IIa clinical trial of ... treat type 1 diabetes. The trial was conducted in ... a U.S. Food and Drug Administration (FDA) Investigational ...
(Date:10/22/2014)... , Oct. 21, 2014  Early symptoms of ... or unnoticed, but new technology, coupled with yearly, ... leading to earlier detection of eye diseases, including ... million Americans. If left untreated, these diseases can ... Recently, optometric researchers have deployed ...
Breaking Medicine Technology:Pat Mackin Joins CryoLife Board of Directors 2Pat Mackin Joins CryoLife Board of Directors 3Oramed Pharmaceuticals Reports Positive Top-Line Data from U.S. Phase IIa Trial with Oral Insulin in Type 1 Diabetes 2Oramed Pharmaceuticals Reports Positive Top-Line Data from U.S. Phase IIa Trial with Oral Insulin in Type 1 Diabetes 3Oramed Pharmaceuticals Reports Positive Top-Line Data from U.S. Phase IIa Trial with Oral Insulin in Type 1 Diabetes 4Technology Advancements Enhance Early Detection of Eye Diseases Associated with Diabetes 2Technology Advancements Enhance Early Detection of Eye Diseases Associated with Diabetes 3
... ADA,s 2009 Convention -- When Shawnae Jebbia won the Miss ... fairytale career. She appeared at events throughout the world, worked ... Shawnae,s world unexpectedly changed when she was diagnosed with hearing ... she had a difficult time understanding and accepting the sudden ...
... Oct. 29 Mettler-Toledo International Inc. (NYSE: MTD ) today announced ... , Sales in local currency declined by 12% in ... negative currency impact. , Net earnings per diluted ... third quarter of 2008. Adjusted EPS was $1.36, a 6% ...
Cached Medicine Technology:Former Miss USA Shawnae Jebbia Shines with Siemens Pure 2Former Miss USA Shawnae Jebbia Shines with Siemens Pure 3Mettler-Toledo International Inc. Reports Third Quarter 2009 Results 2Mettler-Toledo International Inc. Reports Third Quarter 2009 Results 3Mettler-Toledo International Inc. Reports Third Quarter 2009 Results 4Mettler-Toledo International Inc. Reports Third Quarter 2009 Results 5Mettler-Toledo International Inc. Reports Third Quarter 2009 Results 6Mettler-Toledo International Inc. Reports Third Quarter 2009 Results 7Mettler-Toledo International Inc. Reports Third Quarter 2009 Results 8Mettler-Toledo International Inc. Reports Third Quarter 2009 Results 9Mettler-Toledo International Inc. Reports Third Quarter 2009 Results 10Mettler-Toledo International Inc. Reports Third Quarter 2009 Results 11Mettler-Toledo International Inc. Reports Third Quarter 2009 Results 12Mettler-Toledo International Inc. Reports Third Quarter 2009 Results 13
Symbia T, a TruePoint SPECTCT system, combines a dual-detector variable angle gamma camera with a CT scanner optimized for rapid, accurate attenuation correction of the nuclear data....
... analyzer and data management system ,RADIANCE ... traditional needs of data management systems (DMS), ... management of STAT analyzer systems., ,The RADIANCE ... solution for both STAT analyzers and hospital ...
... is a comprehensive IT solution that ... admission to follow-up. This scalable solution ... diagnostic tools from syngo Dynamics with ... longitudinal clinical repository that becomes a ...
... the AXIOM Artis dBC Magnetic Navigation ... navigation system equipped with digital flat ... is uniquely capable of improving the ... to facilitate increased efficiency and productivity ...
Medicine Products: