Navigation Links
Support cells, not neurons, lull the brain to sleep
Date:1/28/2009

Brain cells called astrocytes help to cause the urge to sleep that comes with prolonged wakefulness, according to a study in mice, funded by the National Institutes of Health. The cells release adenosine, a chemical known to have sleep-inducing effects that are inhibited by caffeine.

"Millions of Americans suffer from disorders that prevent a full night's sleep, and others from pilots to combat soldiers have jobs where sleepiness is a hazard. This research could lead to better drugs for inducing sleep when it is needed, and for staving off sleep when it is dangerous," says Merrill Mitler, Ph.D., a program director with the NIH's National Institute of Neurological Disorders and Stroke (NINDS).

The study appears Jan. 29, 2009 in Neuron, and was funded by NINDS, the National Institute of Mental Health (NIMH) and the National Institute on Aging (NIA), all part of NIH. It is the result of a collaboration among Michael Halassa, M.D., and Philip Haydon, Ph.D., at Tufts University School of Medicine in Boston and Marcos Frank, Ph.D., and Ted Abel, Ph.D. at the University of Pennsylvania School of Medicine in Philadelphia.

Although the exact purpose of sleep is unknown, everyone seems to need it, and some research suggests that it strengthens memories by adjusting the connections between neurons. As the waking hours tick by, all animals experience an increasing urge to sleep, known as sleep pressure. If sleep is delayed, a deep, long sleep usually follows as the body's means of compensating.

Prior studies pointed to adenosine as a trigger for sleep pressure. The chemical accumulates in the brain during waking hours, eventually helping to stimulate the unique patterns of brain activity that occur during sleep.

Dr. Halassa says that the results of the new study show that "adenosine from astrocytes clearly regulates sleep pressure." He notes that this is the first time a non-neuronal cell within the brain has been shown to influence behavior. Unlike neurons, astrocytes do not fire electrical spikes, and they are often described as support cells.

In experiments on mice, Dr. Halassa and his colleagues used a genetic switch, called the dnSNARE transgene, to block the release of adenosine and other chemicals from astrocytes. The researchers then deprived the mice of sleep for short periods, and evaluated them with behavioral tests and with electroencephalography (EEG), a means of recording brain activity.

Mice subjected to the genetic blockade exhibited less sleep pressure than control mice. Following sleep deprivation, they did not need as much compensatory sleep, and during the early phases of sleep, they had patterns of brain activity consistent with low sleep pressure. When they were evaluated with a memory test, they performed as if their sleep had been undisturbed.

The researchers observed similar results when they used certain compounds to block the effects of adenosine on neurons. Neurons have several types of cell-surface receptors that enable them to respond to adenosine, but only pharmacological blockade of the A1 type of receptor was effective. That result shows that adenosine acts through the A1 receptor to produce sleep pressure.

Taken together, the results hint at the possibility of new drugs that could increase or decrease sleep pressure as necessary. The best available sleep aids tend to be effective at inducing sleep, but not effective at keeping it steady throughout the night. Meanwhile, the most commonly used stimulant, caffeine, acts on multiple types of adenosine receptors, and can affect sleep patterns even when it is consumed in the morning. Drugs that target astrocytes or the A1 receptors on neurons might be more effective at fine-tuning the urge to sleep, the study authors say.

The dnSNARE mice also will prove useful for answering some long-standing questions about sleep, experts say. For instance, since the dnSNARE mice are resistant to sleep deprivation, they might help explain why some people need less sleep than others. Further studies of the dnSNARE mice could help reveal why people need sleep at all.

This research "puts astrocytes at the heart of why we sleep," says Dr. Halassa.


'/>"/>

Contact: Daniel Stimson
stimsond@ninds.nih.gov
301-496-5751
NIH/National Institute of Neurological Disorders and Stroke
Source:Eurekalert

Related medicine news :

1. Purkinje Announces EMR Promotions in Support of National Healthcare Reform Initiatives
2. Call- Shadow IP Call Management Software, V.5. Now 64 bit with SIP and Enhanced Platform Support
3. Manhattan Research Survey Finds That Physicians Overwhelmingly Support Commercially-Funded Continuing Medical Education
4. Lance Armstrong Foundation Selects Ogilvy Public Relations Worldwide to Support the LIVESTRONG Global Cancer Campaign
5. Impac Software Announces Clinical Release of RapidArc Support
6. Technology Leaders Call on Congress to Support Investments in Digital Infrastructure as Part of Economic Stimulus and Recovery Plan
7. Grassroots Group Gets Travel Advantage Network Support
8. Developing countries need support to ethically conduct unlinked anonymous HIV testing
9. The Quantum Group Announces Support of Technology Bill Before Congress
10. Seattle Reproductive Medicine Study Investigates Newly Formulated Medications for Luteal Support in IVF
11. National Council of Legislators From Gaming States Adopts Resolution Supporting 100% Smokefree Gaming Venues
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/27/2016)... ... June 27, 2016 , ... ... its strategic partnership with Connance, a healthcare industry leader providing predictive analytics ... proprietary technology combine to provide health systems, hospitals and ambulatory surgical centers ...
(Date:6/26/2016)... ... June 27, 2016 , ... Quality metrics are proliferating in cancer care, ... remain in the eye of the beholder, according to experts who offered insights and ... Journal of Managed Care. For the full issue, click here . , For ...
(Date:6/26/2016)... ... June 26, 2016 , ... PawPaws brand pet supplements owned ... developed to enhance the health of felines. The formula is all-natural and is made ... in the PawPaws Cat Kidney Support Supplement Soft Chews are Astragalus Root ...
(Date:6/25/2016)... D.C. (PRWEB) , ... June 25, 2016 , ... ... discuss health policy issues and applications at AcademyHealth’s Annual Research Meeting June 26-28, ... their work on several important health care topics including advance care planning, healthcare ...
(Date:6/25/2016)... ... 25, 2016 , ... "With 30 hand-drawn hand gesture animations, FCPX users can ... CEO of Pixel Film Studios. , ProHand Cartoon’s package transforms over 1,300 hand-drawn ... X . Simply select a ProHand generator and drag it above media or text ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... CAMBRIDGE, Mass. , June 24, 2016 /PRNewswire/ ... the Spaulding Rehabilitation Network,s Dean Center for ... of Physical Medicine and Rehabilitation, MIT Hacking Medicine, ... Center for Innovation, today announced the five finalists ... Hackathon for Lyme disease.  More than 100 scientists, ...
(Date:6/24/2016)... Dehaier Medical Systems Ltd. (NASDAQ: DHRM ) ... medical devices and wearable sleep respiratory products in ... with Hongyuan Supply Chain Management Co., Ltd. (hereinafter referred ... to develop Dehaier,s new Internet medical technology business. ... Hongyuan Supply Chain,s sales platform to reach Dehaier,s dealers ...
(Date:6/24/2016)... , June 24, 2016   Pulmatrix, Inc ., ... developing innovative inhaled drugs, announced today that it was ... Investments reconstituted its comprehensive set of U.S. and ... "This is an important milestone for Pulmatrix," said Chief ... shareholder awareness of our progress in developing drugs for ...
Breaking Medicine Technology: