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Supplements of Red Wine Antioxidant Don't Help Obese Men
Date:11/28/2012

By Denise Mann
HealthDay Reporter

WEDNESDAY, Nov. 28 (HealthDay News) -- Despite showing early promise in some animal studies, supplements of resveratrol, an antioxidant found aplenty in red wine, did not improve insulin sensitivity or heart health in obese men, a small trial found.

Researchers found no difference in insulin sensitivity -- the measure of how well the body uses the hormone insulin -- in 24 obese but otherwise healthy men who took daily 1,500-milligram doses of resveratrol compared to other men who took an inactive placebo for four weeks.

Nor were there any changes in other signs of heart health, including blood pressure, levels of blood fats called triglycerides and other fats.

The study, led by Dr. Morten Poulsen at Aarhus University Hospital in Denmark, appears online Nov. 28 in the journal Diabetes.

Dr. Vivian Fonseca, president of medicine and science for the American Diabetes Association, said he is not surprised that the study did not show any benefits associated with the resveratrol supplements.

"People who drink red wine and do so in moderation may have healthy lifestyles that may allow them to live longer and decrease their insulin sensitivity, but putting it into a pill doesn't solve the problem for people who live unhealthy lives, like the men in the study," Fonseca said. "I think some of the initial animal studies on resveratrol were hyped far more than they should have been and this study should put all of that to rest."

Dr. John Buse, a professor of medicine at the University of North Carolina at Chapel Hill, agreed. "It is nice to see the lack of efficacy so elegantly demonstrated," he said. "There cannot be much question remaining at this point."

People at risk for diabetes can take preventive measures, he noted. "The most important thing is to be screened for diabetes if you are at risk," Buse said. This includes everyone older than 45 and youn
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