Navigation Links
Supplements and cancer prevention: A cautionary tale
Date:4/25/2012

Government regulators and the scientific community should work to ensure that they give clear guidance to the public about dietary supplements and cancer risk, according to a commentary published April 25 in the Journal of the National Cancer Institute.

Evidence from animal, in vitro and observational studies has suggested that taking dietary supplements may lower cancer risk. However, the small number of randomized controlled studies, the gold standard in evidence-based medicine, has not confirmed thisand some studies have actually shown that supplements may increase cancer risk. Still, the supplement industry is booming, with estimated annual sales at $30 billion in the U.S.

To examine the potential role of dietary supplements and cancer risk, Maria Elena Martinez, Ph.D., of the University of California San Diego Moores Cancer Center and colleagues, looked at observational studies of several supplements, including anti-oxidants, folic acid, vitamin D, and calcium. Several observational studies found that diets high in fruits and vegetables were associated with lower risk of certain cancers, including respiratory and gastrointestinal. Specifically, with respect to anti-oxidant supplements, the authors found that: "The importance of oxidative stress for carcinogenesis does not establish that the administration of supplemental antioxidants will protect against the carcinogenesis that oxidative stress may induce." Furthermore, they write, "Supplementation by exogenous antioxidants may well be a two-edged sword; these compounds could, in vivo, serve as pro-oxidants or interfere with any of a number of protective processes such as apoptosis induction." Indeed, several antioxidant trials the researchers examined reported increased cancer risks with supplementation. They looked at trials with supplements using folic acid, vitamin D and calcium, among other compounds.

The researchers caution against taking dietary supplements for cancer prevention, adding that many expert committees and organizations have concluded that nutritional supplements have little or no benefit in cancer prevention. They say that more randomized control trialsspanning many years instead of just a feware needed to verify the effect of nutritional supplementation in cancer risk.

Meanwhile, people continue to take supplements, spurred by manufacturers' suggestions that supplements are healthy at best and harmless at worst. Furthermore, believers in supplements assume that they are well regulated, the authors write. "These beliefs underscore the need for efforts by scientists and government officials to encourage the public to make prudent decisions based on sound evidence with respect to use of dietary supplements for cancer prevention."


'/>"/>
Contact: Zachary Rathner
Zachary.Rathner@oup.com
301-841-1286
Journal of the National Cancer Institute
Source:Eurekalert

Related medicine news :

1. Reliv Foundation Donates $450,000 In Nutritional Supplements to Haitian Relief Efforts
2. Buy HGH Website Educates Consumers on the Pros and Cons of Human Growth Hormone Supplements
3. ConsumerLab.com Finds Carcinogenic form of Chromium in Supplements, Including Those for Weight Loss
4. DiscountSupplements.com Launches Website With the Cheapest Supplements Prices and Fastest Shipping
5. IN Pet Supplements Face Challenges in New China Market as Imitation Products Continue to Baffle Consumers
6. ProbioticSmart.com Re-Launches Newly Expanded Online Store for Human, Pet, and Livestock Health Products and Supplements
7. Arsa Offers High Quality Supplements, Cosmetics and Magic Scents from Mexico for Less Than $10
8. Supplements Might Reduce Breast Cancer Risk
9. DHA Supplements for Mom Good for Preemies
10. The effect of dietary supplements, acids and animal protein on gastrointestinal disorders
11. High doses of antioxidant supplements induce stem cell genetic abnormalities
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/24/2017)... ... July 24, 2017 , ... SignatureCare Emergency Center ... awarded for the fall semester to a deserving student. Get your applications in ... scholarship was awarded to Mariana Castillo who is a nursing student at Prairie View ...
(Date:7/24/2017)... ... July 24, 2017 , ... ... Substance Abuse and Mental Health Services Administration’s (SAMHSA) State Targeted Response to the ... of Health Care Services, will facilitate the development of a hub and spoke ...
(Date:7/24/2017)... Los Angeles, California (PRWEB) , ... July 24, ... ... office building fire in Oakland, California effectively destroyed the construction site and threatened ... to a July 7th article on NBCLosAngeles.com. Los Angeles Area ...
(Date:7/24/2017)... ... July 24, 2017 , ... The International Essential Tremor Foundation (IETF) will ... essential tremor (ET). The seminar will take place on Saturday, Aug. 26 at the ... The program will run from 9 a.m. to 12 p.m., with check-in beginning at ...
(Date:7/24/2017)... (PRWEB) , ... July 24, 2017 , ... Axiad ... organizations, today announced it has partnered with WALLIX to expand its solution ... 800-171 . , There are a number of ways to address the authentication requirements ...
Breaking Medicine News(10 mins):
(Date:7/17/2017)... 17, 2017  MedX Holdings, Inc., the manufacturer and ... and rehabilitation equipment, today announced the national roll out ... considered the gold standard for the treatment of low ... strengthening equipment. How ... physician or practice who prescribe the MedX Home Back ...
(Date:7/13/2017)... 13, 2017  Centurion Medical Products, a leader in medical product ... fecal impaction removal device for hospice patient care. ... Centurion Medical Products ... Patient pain management and emotional comfort are part ... alleviate patient pain while preventing unneeded emergency department admission due to ...
(Date:7/12/2017)... INDIANAPOLIS , July 12, 2017  Eli Lilly and ... settlement agreement with generic companies to resolve pending patent litigation ... Virginia regarding the Cialis ® ... expire on April 26, 2020. As part of the agreement, ... on September 27, 2018. "The unit dose patent ...
Breaking Medicine Technology: