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Supplement of Red Wine Ingredient Won't Help Healthy Women: Study
Date:10/25/2012

THURSDAY, Oct. 25 (HealthDay News) -- Healthy middle-aged women do not benefit from taking resveratrol supplements, new study shows. Resveratrol is the ingredient in red wine thought to improve insulin sensitivity, reduce the risk of heart disease and increase longevity.

Although resveratrol supplementation doesn't appear to help these women, it's possible that another ingredient in red wine may provide a health benefit, the researchers from the Washington University School of Medicine in St. Louis pointed out.

"Resveratrol supplements have become popular because studies in cell systems and rodents show that resveratrol can improve metabolic function and prevent or reverse certain health problems like diabetes, heart disease and even cancer," senior investigator Dr. Samuel Klein, director of Washington University's Center for Human Nutrition, said in a university news release. "But our data demonstrate that resveratrol supplementation does not have metabolic benefits in relatively healthy, middle-aged women."

The study involved 29 postmenopausal women who were generally healthy and did not have type 2 diabetes. The researchers had 15 of the women take a 75 milligram over-the-counter resveratrol supplement daily for 12 weeks. They noted that this was the equivalent of drinking over two gallons of red wine. The insulin sensitivity and metabolic response of these women was then compared to 14 other women who took a inactive placebo pill over the course of the study.

"It's the most sensitive approach we have for evaluating insulin action in people," said Klein. "And we were unable to detect any effect of resveratrol. In addition, we took small samples of muscle and fat tissue from these women to look for possible effects of resveratrol in the body's cells, and again, we could not find any changes in the signaling pathways involved in metabolism."

Previous studies suggested drinking red wine lowers the risk for
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