Navigation Links
Supermaterial gives rejected drugs a new chance
Date:7/22/2014

More than 80 percent of all drug candidates in the pharma R&D suffer from poor solubility and are therefore rejected early in the drug discovery process. Now Uppsala University researchers show that the new material Upsalite, has great potential for development of new formulations of these rejected drugs.

These findings could allow the pharma companies to open up large libraries of potent drug candidates earlier discarded due to solubility problems and try them again together with Upsalite, says Maria Strmme, Professor at the Division of Nanotechnology and Functional Materials at Uppsala University.

The new material was presented last year by her research group. The material had the highest surface area ever measures fr an alkali earth metal carbonate; 800 square meters per gram.

In a new study, published in International Journal of Pharmaceutics the researchers show that the extremely porous magnesium carbonate Upsalite may provide a great potential for the development of new drug formulations of active pharmaceutical ingredients with poor aqueous solubility.

About 40 percent of newly marketed drugs have poor solubility and more than 80 percent of drug candidates in the R&D pipeline fail because of solubility problems. These drugs subsequently have low bioavailability (i.e., they are difficult for the body to take up), which limit their therapeutic efficacy and hence seldom leads to new pharmaceuticals.

In the new study the pain killer Ibuprofen was used as a model substance for poorly soluble drugs and it was shown that crystallisation of the drug was completely supressed in the formulation, resulting in both a higher solubility and a three times faster dissolution rate of the drug.

- We think that the narrow pores hinder the drug molecules from organizing in a poorly soluble crystalline form and are forced to maintain an amorphous structure that is easier for the body to absorb, says Johan Gmez de la Torre.

The discovery will be commercialized though the University spin-out company Disruptive Materials AB that has been formed by the researchers together with the holding company of Uppsala University.

More information about the research group on Uppsala University website


'/>"/>

Contact: Maria Strømme
maria.stromme@angstrom.uu.se
46-070-167-9104
Uppsala University
Source:Eurekalert

Related medicine news :

1. U.S. Gives Green Light to Publish Controversial Bird Flu Research
2. Image share project gives patients and physicians anytime, anywhere access to medical images
3. Procedure gives patients with A-fib who cant take blood thinners alternative to reduce stroke
4. UMD team gives drug dropouts a second chance
5. FDA Panel Gives Blessing to New Weight-Loss Drug
6. Amazon Tribe Gives Clues to Heart-Healthy Lifestyles
7. Killer stainless steel: New process gives icon of cleanliness antibacterial coating
8. Aurora Dentist Gives Patients Big Savings With Teeth in a Day Implants
9. OC Firm Gives Back to Young Athletes
10. Study Gives First Evidence That Adult Human Lungs Can Regrow
11. FDA Gives Nod to New Breast Cancer Drug
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/30/2017)... ... ... An inventor and manicurist from Greet, S.C., wants to offer people a new way to ... clean and healthy feet, so I know the importance of proper foot care," he said. ... the FOOT-TRAN SYSTEM." , The FOOT-TRAN SYSTEM enables a user to clean and exfoliate the ...
(Date:3/29/2017)... ... 29, 2017 , ... ARI Network Services, Inc. (NASDAQ: ARIS) announced today that ... for its network of more than 650 U.S.-based dealers. Rhino, a member of the ... and flail mowers and cutters, rear blades, post hole diggers, pasture renovators, tillers, disc ...
(Date:3/29/2017)... (PRWEB) , ... March 30, 2017 , ... CHARM CITY ... City Run has announced that Mercy Medical Center will serve as the official title ... Mid-Atlantic region. On Sunday, June 25, 2017, thousands of women will walk or run ...
(Date:3/29/2017)... Louisiana (PRWEB) , ... March 29, 2017 , ... ... in three Hours at a Walgreens store in Mississippi. AngioGenesis Labs, makers of ... Walgreens Stores in two southeastern states. Ingredients in HeartBoost, an over the counter ...
(Date:3/29/2017)... ANN ARBOR, Mich. (PRWEB) , ... ... ... Global Retailer and Manufacturer Alliance (GRMA) is growing as it continues developing ... the dietary supplement industry. The organization, which plans to publish the first ...
Breaking Medicine News(10 mins):
(Date:3/29/2017)... , March 29, 2017  The Global Health ... public-private partnership formed to battle infectious diseases around ... US$23 million* that could help deliver a range ... debilitating conditions. This latest round ... 3 clinical trial testing a pediatric formulation of ...
(Date:3/29/2017)... BEACH, Calif. , March 29, 2017 /PRNewswire/ ... have recognized remote monitoring devices like  Soberlink Systems ...   The consensus paper, published in early 2017, ... practical and valuable in managing patient recovery." ... in the Journal of Addiction Medicine, detail a ...
(Date:3/29/2017)...  The leader in accelerated orthodontics, OrthoAccel ® ... , Manal Ibrahim , Kenji Ojima , ... the featured microlecture presenters at the AcceleDent ® ... (AAO) Annual Session, April 21-25, 2017. Orthodontists and their ... at 11:20 a.m. On the opening morning of AAO ...
Breaking Medicine Technology: