Navigation Links
Supermaterial gives rejected drugs a new chance
Date:7/22/2014

More than 80 percent of all drug candidates in the pharma R&D suffer from poor solubility and are therefore rejected early in the drug discovery process. Now Uppsala University researchers show that the new material Upsalite, has great potential for development of new formulations of these rejected drugs.

These findings could allow the pharma companies to open up large libraries of potent drug candidates earlier discarded due to solubility problems and try them again together with Upsalite, says Maria Strmme, Professor at the Division of Nanotechnology and Functional Materials at Uppsala University.

The new material was presented last year by her research group. The material had the highest surface area ever measures fr an alkali earth metal carbonate; 800 square meters per gram.

In a new study, published in International Journal of Pharmaceutics the researchers show that the extremely porous magnesium carbonate Upsalite may provide a great potential for the development of new drug formulations of active pharmaceutical ingredients with poor aqueous solubility.

About 40 percent of newly marketed drugs have poor solubility and more than 80 percent of drug candidates in the R&D pipeline fail because of solubility problems. These drugs subsequently have low bioavailability (i.e., they are difficult for the body to take up), which limit their therapeutic efficacy and hence seldom leads to new pharmaceuticals.

In the new study the pain killer Ibuprofen was used as a model substance for poorly soluble drugs and it was shown that crystallisation of the drug was completely supressed in the formulation, resulting in both a higher solubility and a three times faster dissolution rate of the drug.

- We think that the narrow pores hinder the drug molecules from organizing in a poorly soluble crystalline form and are forced to maintain an amorphous structure that is easier for the body to absorb, says Johan Gmez de la Torre.

The discovery will be commercialized though the University spin-out company Disruptive Materials AB that has been formed by the researchers together with the holding company of Uppsala University.

More information about the research group on Uppsala University website


'/>"/>

Contact: Maria Strømme
maria.stromme@angstrom.uu.se
46-070-167-9104
Uppsala University
Source:Eurekalert

Related medicine news :

1. U.S. Gives Green Light to Publish Controversial Bird Flu Research
2. Image share project gives patients and physicians anytime, anywhere access to medical images
3. Procedure gives patients with A-fib who cant take blood thinners alternative to reduce stroke
4. UMD team gives drug dropouts a second chance
5. FDA Panel Gives Blessing to New Weight-Loss Drug
6. Amazon Tribe Gives Clues to Heart-Healthy Lifestyles
7. Killer stainless steel: New process gives icon of cleanliness antibacterial coating
8. Aurora Dentist Gives Patients Big Savings With Teeth in a Day Implants
9. OC Firm Gives Back to Young Athletes
10. Study Gives First Evidence That Adult Human Lungs Can Regrow
11. FDA Gives Nod to New Breast Cancer Drug
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/19/2017)... ... 18, 2017 , ... President Donald Trump signed into law ... for greater public access to over-the-counter (OTC) hearing aids. , The measure enables ... without being seen by a certified and licensed audiologist. , “The American ...
(Date:8/19/2017)... ... 19, 2017 , ... Praeclarus Press has launched a ... the diversity of the breastfeeding mothers, using bright colors and contemporary themes. ... illustrations are also available on tote bags, notepads, smartphone cases, clocks, and travel ...
(Date:8/19/2017)... ... August 19, 2017 , ... Physician Partners of America Pain ... an interventional pain management physician. He brings a wealth of pain management experience ... and significant experience in spinal cord stimulation for chronic pain. , Dr. Ahmed ...
(Date:8/18/2017)... Lynchburg, VA (PRWEB) , ... August 18, 2017 , ... ... to the Democratic Republic of Congo (DRC) thanks to an ambitious venture that conjoined ... as well as the generous support of the Liberty community. These shoes will save ...
(Date:8/18/2017)... ... August 18, 2017 , ... ... campaign, advocating for active, healthy lifestyles and highlighting the importance of proactive eye ... hearing impairments and shares the latest innovations in hearing aid technology. , ...
Breaking Medicine News(10 mins):
(Date:8/15/2017)...   Mostyn Law and Gulf Coast Regional Blood Center ... . The Mostyn Law family has had 3 members ... why Mostyn Law is partnering with Gulf Coast Regional ... appreciation. Blood supplies are running low. Gulf Coast Regional ... needs in August. That is why the blood center reached out ...
(Date:8/14/2017)... and PETACH TIKVAH, Israel , ... BCLI), a leading developer of adult stem cell technologies ... quarter ending June 30, 2017. ... preparing for our pivotal Phase 3 trial to investigate ... , President and Chief Executive Officer of BrainStorm. "We ...
(Date:8/7/2017)... , Aug. 7, 2017 Insightin ... member acquisition, retention, and engagement, announced the selection ... Strategy and Product Development, effective as of February 2017. ... and technology implementation strategy for our clients. Wood ... experience in consulting and business analytics within the ...
Breaking Medicine Technology: