Navigation Links
'Super' enzyme protects against dangers of oxygen
Date:1/29/2013

Just like a comic book super hero, you could say that the enzyme superoxide dismutase (SOD1) has a secret identity. Since its discovery in 1969, scientists believed SOD1's only role was to protect living cells against damage from free radicals. Now, researchers at the Johns Hopkins Bloomberg School of Public Health have discovered that SOD1 protects cells by regulating cell energy and metabolism. The results of their research were published January 17, 2013, in the journal Cell.

Transforming oxygen to energy for growth is key to life for all living cells, which happens either through respiration or fermentation. When oxygen is plentiful, respiration normally takes over; however certain cells fail to respire in spite of abundant oxygen and instead ferment, leading to uncontrolled cell growtha hallmark of cancer.

Using the baker's yeast S. cerevisiae as well as a human cell line, researchers Valeria C. Culotta, PhD, and colleague Amit Reddi from the Department of Biochemistry and Molecular Biology determined that SOD1 transmits signals from oxygen and glucose to repress respiration. This signaling is accomplished through SOD1 protection of another enzyme known as casein kinase 1-gamma (CK1γ), which is an important key to the switch between respiration and fermentation.

"SOD enzymes are present in virtually all living cells, from the most ancient bacteria to every cell in the human body," explained Culotta. "I've been telling my students to think of SOD1 as a superhero. It not only defends cells from damaging free radicals, but also has a secret life as a guardian of cell energy and metabolism."

"Our findings provide new clues as to how rapidly dividing cellsfrom yeast to human cancersmay escape the urge to respire and instead choose fermentation to promote rapid growth," said Culotta.

"SOD1 has long been recognized as an important enzyme in protection from oxidative stress, but this work establishes an important new function for the enzyme in cellular metabolism," said Vernon Anderson, PhD, of the National Institutes of Health's National Institute of General Medical Sciences, which partly funded the study. "The results provide important insight into how SOD1 and oxygen radicals push cellular energy metabolism towards fermentation, a feature of some disease states, including cancer."


'/>"/>

Contact: Tim Parsons
tmparson@jhsph.edu
410-955-7619
Johns Hopkins University Bloomberg School of Public Health
Source:Eurekalert

Related medicine news :

1. Sesame Street Live's Super Grover Visits WHEDco in the South Bronx to Teach Low-Income Children What it Takes to be a Super Hero
2. A Bouquet of Health! 5 Super Flowers to Explore in 2013
3. Global Autism Project Announces Distance Supervision for Autism Professionals
4. LSD Reports LED Lighting Display at Superbowl XLVII on Mercedes-Benz Superdome in New Orleans
5. Havana Street Businesses “Sweep” Supermarket to Benefit Comitis Crisis Center
6. Super Bowl Party at Via Brasil Steakhouse this 2013
7. Three Surgeons of Los Angeles Colon and Rectal Surgical Associates Have Received the Prestigious 2013 Los Angeles SuperDoctors Award for the Second Year in a Row
8. MotoSport.com Joins Rockstar Energy Racing for 2013 Monster Energy AMA Supercross and 2013 Lucas Oil AMA Pro Motocross Championships
9. Greenix Pest Control, a Green Pest Control Company, Wins Angie's List Coveted Super Service Award
10. Propecia Lawsuits Being Investigated by Bernstein Liebhard LLP, as Propecia Litigation Pending in New Jersey Superior Court Continues to Move Forward
11. Super-fine sound beam could one day be an invisible scalpel
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/5/2016)... ... 05, 2016 , ... In sleep, when the defenses of the day are ... of patients with eating disorders is significant self-criticism, and consequently these patients experience this ... regarded as maladaptive means for coping with this unease, but also leads to a ...
(Date:2/5/2016)... ... February 05, 2016 , ... ... kitchens, recently announced the debut of their latest mobile kitchen model, featuring customizable ... organizations with modern, high-volume commercial kitchens for use anywhere in the U.S. Many ...
(Date:2/5/2016)... , ... February 05, 2016 , ... Calls Blacklist has ... completely new user interface design and the developer has fixed known bugs within the ... want to on their phone while not consuming any of their device’s battery power ...
(Date:2/5/2016)... ... ... –This week, Atascadero water heater company First Call Plumbing has issued ... report, click here or see below. , There are two main ... the type chosen is almost entirely up to personal preference. However, tankless water heaters ...
(Date:2/5/2016)... , ... February 05, 2016 , ... When one is tired of trying to cram ... There are many reasons to rent a storage unit, but before hastily spending money on ... sometimes you simply need more space. But what one is often not told when utilizing ...
Breaking Medicine News(10 mins):
(Date:2/4/2016)... --  Bernstein Liebhard LLP today announced that a securities ... Court for the District of Arizona ... persons or entities who purchased common shares of Insys Therapeutics ... March 3, 2015 through January 25, 2016 (the "Class Period").  ... violations of the Securities Exchange Act of 1934.  ...
(Date:2/4/2016)... LONDON , Feb. 4, 2016 Summary ... most common cancer and the most common cancer in ... making the disease exceedingly prevalent. The number of women ... few decades, but the number of deaths has declined ... Breast cancer treatment has been revolutionized in the past ...
(Date:2/4/2016)... -- Mettler-Toledo International Inc. (NYSE: MTD ) today ... the highlights: , Sales in local currency ... year.  Reported sales decreased 3% as currency reduced sales ... earnings per diluted share as reported (EPS) were $4.44, ... EPS was $4.65, an increase of 10% over the ...
Breaking Medicine Technology: