Navigation Links
'Super' enzyme protects against dangers of oxygen
Date:1/29/2013

Just like a comic book super hero, you could say that the enzyme superoxide dismutase (SOD1) has a secret identity. Since its discovery in 1969, scientists believed SOD1's only role was to protect living cells against damage from free radicals. Now, researchers at the Johns Hopkins Bloomberg School of Public Health have discovered that SOD1 protects cells by regulating cell energy and metabolism. The results of their research were published January 17, 2013, in the journal Cell.

Transforming oxygen to energy for growth is key to life for all living cells, which happens either through respiration or fermentation. When oxygen is plentiful, respiration normally takes over; however certain cells fail to respire in spite of abundant oxygen and instead ferment, leading to uncontrolled cell growtha hallmark of cancer.

Using the baker's yeast S. cerevisiae as well as a human cell line, researchers Valeria C. Culotta, PhD, and colleague Amit Reddi from the Department of Biochemistry and Molecular Biology determined that SOD1 transmits signals from oxygen and glucose to repress respiration. This signaling is accomplished through SOD1 protection of another enzyme known as casein kinase 1-gamma (CK1γ), which is an important key to the switch between respiration and fermentation.

"SOD enzymes are present in virtually all living cells, from the most ancient bacteria to every cell in the human body," explained Culotta. "I've been telling my students to think of SOD1 as a superhero. It not only defends cells from damaging free radicals, but also has a secret life as a guardian of cell energy and metabolism."

"Our findings provide new clues as to how rapidly dividing cellsfrom yeast to human cancersmay escape the urge to respire and instead choose fermentation to promote rapid growth," said Culotta.

"SOD1 has long been recognized as an important enzyme in protection from oxidative stress, but this work establishes an important new function for the enzyme in cellular metabolism," said Vernon Anderson, PhD, of the National Institutes of Health's National Institute of General Medical Sciences, which partly funded the study. "The results provide important insight into how SOD1 and oxygen radicals push cellular energy metabolism towards fermentation, a feature of some disease states, including cancer."


'/>"/>

Contact: Tim Parsons
tmparson@jhsph.edu
410-955-7619
Johns Hopkins University Bloomberg School of Public Health
Source:Eurekalert

Related medicine news :

1. Sesame Street Live's Super Grover Visits WHEDco in the South Bronx to Teach Low-Income Children What it Takes to be a Super Hero
2. A Bouquet of Health! 5 Super Flowers to Explore in 2013
3. Global Autism Project Announces Distance Supervision for Autism Professionals
4. LSD Reports LED Lighting Display at Superbowl XLVII on Mercedes-Benz Superdome in New Orleans
5. Havana Street Businesses “Sweep” Supermarket to Benefit Comitis Crisis Center
6. Super Bowl Party at Via Brasil Steakhouse this 2013
7. Three Surgeons of Los Angeles Colon and Rectal Surgical Associates Have Received the Prestigious 2013 Los Angeles SuperDoctors Award for the Second Year in a Row
8. MotoSport.com Joins Rockstar Energy Racing for 2013 Monster Energy AMA Supercross and 2013 Lucas Oil AMA Pro Motocross Championships
9. Greenix Pest Control, a Green Pest Control Company, Wins Angie's List Coveted Super Service Award
10. Propecia Lawsuits Being Investigated by Bernstein Liebhard LLP, as Propecia Litigation Pending in New Jersey Superior Court Continues to Move Forward
11. Super-fine sound beam could one day be an invisible scalpel
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/27/2016)... ... June 27, 2016 , ... TopConsumerReviews.com recently awarded their highest ... . , Millions of individuals in the United States and Canada wear eyeglasses. Once ... to both correct vision and make a fashion statement. Even celebrities use glasses as ...
(Date:6/26/2016)... , ... June 26, 2016 , ... Brent Kasmer, a legally blind and certified personal ... personalized through a fitness app. The fitness app plans to fix the two major problems ... offer a one size fits all type program , They don’t eliminate all ...
(Date:6/25/2016)... ... June 25, 2016 , ... "With 30 hand-drawn hand ... project," said Christina Austin - CEO of Pixel Film Studios. , ProHand Cartoon’s ... within Final Cut Pro X . Simply select a ProHand generator and drag ...
(Date:6/25/2016)... ... June 25, 2016 , ... Conventional wisdom preaches the benefits of ... of the latter, setting the bar too high can result in disappointment, perhaps even ... progress toward their goal. , Research from PsychTests.com reveals that behind ...
(Date:6/24/2016)... ... 24, 2016 , ... The Pulmonary Hypertension Association (PHA) learned ... receive two significant new grants to support its work to advance research and ... by recognizing patients, medical professionals and scientists for their work in fighting pulmonary ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... -- Any dentist who has made an implant supported denture ... of them do not even offer this as a viable ... costs involved. And those who ARE able to offer that ... cost that the majority of today,s patients would not be ... , founder of Dental Evolutions Inc. and inventor of Implanova ...
(Date:6/23/2016)... , June 23, 2016 Roche (SIX: RO, ... clearance for its Elecsys BRAHMS PCT (procalcitonin) assay as ... or septic shock. With this clearance, Roche is the ... fully integrated solution for sepsis risk assessment and management. ... bacterial infection and PCT levels in blood can aid ...
(Date:6/23/2016)... Research and Markets has announced the addition of ... their offering. The current ... environment for MedImmune to enter. The US ageing population creates ... drive considerable growth for effective anti-influenza medications. The introduction of ... but development is still in its infancy. ...
Breaking Medicine Technology: