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Super-Thin Drug-Free Coating 'Hides' Stent as It Unblocks Heart Arteries
Date:1/21/2008

luting stents be placed on dual anti-platelet therapy for at least one year. Dual antiplatelet therapy typically includes aspirin and the drug clopidogrel.

In the ATLANTA study, the clopidogrel was discontinued in all patients after 30 days, with no ill effects.

"Although antiplatelet therapy delays the problem of thrombosis in drug-eluting stents, when the therapy is stopped, the problem returns," said Dr. Tamburino. "However, continuing on antiplatelet therapy indefinitely is problematic, too, because it increases the risk of bleeding, and may prevent future surgeries."

The new surface-treated stent was designed to provide an answer to that problem. The stent is made of cobalt chromium and uses a modified open-cell design. The stent is coated with poly[bis(trifluroexthoxy)phosphazene], or Polyzene-F. The surface treatment is approximately 40 nanometers thick, too thin to be seen with a traditional microscope. The antithrombotic, bacterial-resistant coating essentially hides the stent so that the body doesn't react to the device as a foreign object as is the case for bare-metal stents. This, in turn, promotes the healing process so that the stent is incorporated into the body more naturally, preventing the formation of blood clots. After implantation of a traditional stent, the body essentially overreacts to the device, causing the scarring that leads to restenosis.

Polyzene-F was discovered by a group of scientists and has been used in humans for several years to coat tiny particles that embolize (block) arteries and treat a number of conditions, including liver cancer, uterine fibroids and malformed arteries. It's also been tested or is in testing on dental implants, orthopedic implants, breast implants and catheters. Because it is a coating, like Teflon(R) or silicone, it can coat, or be woven or spun onto metals, ceramics and other polymers to improve their performance. Fifteen times slicker than Teflon, Polyzene-F also has applicati
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SOURCE International Symposium on Endovascular Therapy
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