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Sunesis Pharmaceuticals' SNS-595 Shows Clinical Activity in Patients With Relapsed or Refractory Acute Leukemias; Data Presented in Oral Session at 49th Annual Meeting of the American Society of Hematology
Date:12/10/2007

monstrated 10- to 30-fold greater activity than that of flavopiridol in inhibiting transcription. Flavopiridol is a non-selective pan-CDK inhibitor currently in late-stage evaluation for the treatment of CLL.

Dr. Plunkett will present these data during this evening's poster session "CLL: Salvage Therapies and New Agents" from 5:00 p.m. to 7:00 p.m.

"SNS-032 demonstrates potent and selective induction of apoptosis in primary CLL cells at concentrations that we believe are achievable clinically. Data from these non-clinical studies of SNS-032 provide solid support and in vitro validation for our ongoing clinical trial of SNS-032 in patients with advanced CLL or multiple myeloma," said Dr. Adelman.

Conference Call Information

Sunesis management will host a conference call with clinical investigators discussing data presented today at the ASH meeting at 4:00 p.m. Eastern Time/1:00 p.m. Pacific Time.

Individual and institutional investors can access the call via 877-723-9519 (U.S. and Canada) or 719-325-4841 (international). To access the live audio webcast and subsequent archived recording, visit the "Investors and Media - Calendar of Events" section of the Sunesis website at http://www.sunesis.com. Please log on to Sunesis' website several minutes prior to the start of the presentation to ensure adequate time for any software download that may be necessary. A replay of the conference call will be archived on the Sunesis website for two weeks until December 24, 2007.

About Sunesis' Oncology Programs

Sunesis has built a rich portfolio of product candidates in oncology focused on novel pathways and targets, including inhibition of the cell-cycle and survival signaling. SNS-595, a first-in-class naphthyridine analog that intercalates DNA and poisons topoisomerase II causing selective DNA damage, is currently in a Phase 1b clinical trial in patients with acute leukemia and a
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SOURCE Sunesis Pharmaceuticals, Inc.
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