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Sunesis Pharmaceuticals' SNS-595 Shows Clinical Activity in Patients With Relapsed or Refractory Acute Leukemias; Data Presented in Oral Session at 49th Annual Meeting of the American Society of Hematology
Date:12/10/2007

pharmacokinetics. These data were presented today by Dr. Lancet in the "Acute Myeloid Leukemias: Therapy, excluding Transplantation-Novel Therapies" oral session.

"We are pleased to report these promising results from our Phase 1 trial of SNS-595 in advanced leukemia patients. We believe three significant observations have emerged from this study: SNS-595 demonstrates anticancer activity among patients with advanced disease; SNS-595 is generally well tolerated -- even among elderly patients; and SNS-595 may be administered on either a once- or twice-weekly schedule," said Daniel C. Adelman, M.D., Sunesis' Senior Vice President, Development and Chief Medical Officer. "Data from our Phase 1 clinical trial provide strong support for our development plans for SNS-595 as a single agent and in combination with other anti-leukemic agents, such as cytarabine."

Poster Presentation: Mechanism of Action of SNS-032, a Novel Cyclin-Dependent Kinase Inhibitor, in Chronic Lymphocytic Leukemia: Comparison with Flavopiridol (Abstract # 3112)

Results from a non-clinical study of SNS-032, a potent and selective inhibitor of CDKs 2, 7 and 9, further characterized SNS-032's potential mechanism of action and favorably compared SNS-032's in vitro activity with flavopiridol in CLL cells obtained from patients.

SNS-032 acts by inhibiting the activity of CDKs 7 and 9 and reducing RNA synthesis, as well as down-regulating the expression of anti-apoptotic proteins, such as myeloid cell leukemia sequence 1, or MCL-1, and X-linked Inhibitor of Apoptosis Protein, or XIAP, both of which are associated with CLL-cell survival and proliferation. SNS-032 induces apoptosis in CLL cells, and its activity appears to be independent of p53 activity. This profile is significant as loss of p53 function has been implicated in the development of drug resistance with other agents. In a direct comparison, SNS-032 was more potent than flavopiridol in CLL cells. In addition, SNS-032 de
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SOURCE Sunesis Pharmaceuticals, Inc.
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