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Sunburns strike twice
Date:2/26/2014

important role in metastasis. They are attracted by alarm signals emitted by UV-damaged keratinocytes in the epidermis. The use of special mouse strains which lack important molecules required for the activation of innate immune defense shed light on the underlying signaling pathways.

Inflammatory mediators promote melanoma cell motility

Researchers in the LIMES Institute of the University of Bonn developed new experimental methods to investigate the interaction between melanoma cells and cells of the inner blood vessel walls, known as endothelial cells. In doing so, they observed that melanoma cells can migrate particularly effectively on blood vessel surfaces. "Melanoma cells increase their motility in an inflammatory environment," says Prof. Dr. Waldemar Kolanus.

Further investigations with human melanoma cells and modern genomic methods provided insights how inflammatory mediators stimulate melanoma cells migration. "During embryonic development pigment cell precursors travel long distances along blood vessels in the body in order to reach their final destination in the skin. These migratory programs are erroneously reactivated in melanoma cells by inflammation," says Prof. Dr. Michael Hlzel from the Institute of Clinical Chemistry and Clinical Pharmacology in Bonn.

Important insights for new treatment strategies

"Our findings may explain why patients with superficially ulcerated melanomas and neutrophil infiltration frequently develop organ metastases" says Prof. Tting. The researchers hope to develop new forms of targeted therapy in the future which specifically interfere with inflammatory signaling cascades and inhibit the migration of melanoma cells on the surfaces of blood vessels. The interdisciplinary cooperation between different research groups in Bonn within the Collaborative Research Center 704 and the Excellence Cluster ImmunoSensation provide an excellent basis for such ambitious projects
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Contact: Dr. Thomas Tüting
Thomas.Tueting@ukb.uni-bonn.de
49-228-287-15370
University of Bonn
Source:Eurekalert

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