Navigation Links
Sunburns strike twice
Date:2/26/2014

Melanoma is particularly dangerous because it can form metastases in vital organs such as the lungs, liver or brain. UV radiation is considered to be the most significant triggering factor. An interdisciplinary team of researchers from the University Hospital and the LIMES Institute of the University of Bonn has now discovered that sunburns contribute to the development of this malignant disease not only through direct alteration of pigment cell genomes but also indirectly through inflammatory processes in the surrounding tissue. The results are now being published online in the renowned journal "Nature".

According to predictions from the Robert Koch Institute, approximately 20,000 people in Germany will develop malignant melanoma in 2014. More than 2500 of those affected will die from metastases to internal organs. "The inflammatory reaction of the skin after severe sun exposure promotes the early migration of melanoma cells along vessels within the body," says Prof. Dr. Thomas Tting, professor of Experimental Dermatology at the University of Bonn Hospital and leader of the study team.

Melanoma cells migrate along blood vessels

To understand the development and early metastasis of malignant melanoma, the researchers developed experimental models in mice which allowed them to investigate the effect of inflammatory responses following UV exposure. "We repeatedly observed increased melanoma metastases in the lungs of UV-irradiated mice," reports the dermatologist Dr. Evelyn Gaffal. Analyses of melanoma tissue sections revealed the spread of tumor cells along blood vessel surfaces in inflamed skin. Using modern methods of fluorescence and electron microscopy, the researchers observed a close association between melanoma cells, inner blood vessel walls and immune cells, especially neutrophils.

Activated neutrophils pave the way for melanoma cells

Further experiments showed that neutrophils play an
'/>"/>

Contact: Dr. Thomas Tüting
Thomas.Tueting@ukb.uni-bonn.de
49-228-287-15370
University of Bonn
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. UV Technologies Announces iTanSmart Sun Tan App for Apple iPhone and iPod Touch Helps Prevent Sunburns
2. Vulvar condition causing painful sex strikes twice as many Hispanic women
3. 1-800-HOMECARE Comments on Recent Nursing Home Theft That Strikes Seniors andFamilies
4. Explaining why so many cases of cardiac arrest strike in the morning
5. ServiceMaster by Singer Helping to Inform the Public That This is the 10th Annual of National Preparedness Month; Will You Be Ready if Disaster Strikes?
6. Women's Strike Force Announces First Fund Distribution to Virginia House of Delegates Candidates for November Race
7. Hurricane Season Cause flooding ServiceMaster by Singer there when disaster strikes.
8. Kars4Kids Sustains Severe Lightning Strike; Captures Amazing Footage
9. Women’s Strike Force Endorses Democrats For Top Elected Jobs in Commonwealth of Virginia
10. DePuy ASR Hip Recall: Bernstein Liebhard LLP Comments on DePuy’s Motion to Strike Costs in Wake of $8.25 Million DePuy ASR Lawsuit Judgment
11. Fatigue Affects Baseball Players Strike-Zone Judgment: Study
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/14/2014)... orphaned by HIV/AIDS in South Africa may provide insight ... behavior issues in other areas of the world, which ... that could lead to successful interventions. , A ... United Nations mentions that due to the HIV/AIDS pandemic, ... African, children are at an increased risk for mental ...
(Date:4/14/2014)... A new study shows that moderate to severe ... risk of stroke, cancer and death. , Results of ... to severe obstructive sleep apnea were four times more ... times more likely to have a stroke (HR = ... (HR = 3.4), and 2.5 times more likely to ...
(Date:4/14/2014)... Dallas study involving serious youth offenders, the answer to one ... seven years: "How long do you think you,ll live?", According ... offending over time., Author Dr. Alex Piquero said the study ... of them offend at very high rates and commit more ... much later in life offend much less., "In a lot ...
(Date:4/14/2014)... with symptoms increasing dramatically during some of the most important ... has found. , Depressive symptoms increased on average by 68 ... young men, who were around 25 years old when they ... their children. The results of the study were published April ... is the first to identify when young fathers are at ...
(Date:4/14/2014)... Lower weight babies and babies who aren,t breastfed ... risk of developing chronic inflammation and related health ... study. , "There were good reasons to hypothesize ... inflammation in adulthood," says Thomas McDade (Northwestern University), ... in the Child & Brain Development program. "It ...
Breaking Medicine News(10 mins):Health News:Researchers identify children with emotional behavior difficulties 2Health News:Researchers identify children with emotional behavior difficulties 3Health News:Study links severe sleep apnea to increased risk of stroke, cancer and death 2Health News:UT Dallas study: Youth who fail to envision future commit more crimes 2Health News:Young dads at high risk of depression, too 2Health News:Low birth weight, less breastfeeding create later health risks 2
... 29 Miami physician Roberto Rodriguez, 54, was sentenced today ... Medicare fraud scheme involving HIV infusion services, announced Assistant Attorney ... Attorney Jeffrey H. Sloman of the Southern District of Florida ... Health & Human Services (HHS). Rodriguez was also ordered to ...
... HealthFitness Corporation (NYSE Amex: FIT ... management solutions, announced today that the Company was added to ... on June 26, 2009, when Russell Investments reconstituted its comprehensive ... , About HealthFitness , HealthFitness is a leading ...
... BioMed Realty Trust, Inc. (NYSE: ... million loan with John Hancock Life Insurance Company, TIAA-CREF, and ... a single property - the Center for Life Science | ... that recently received Gold LEED(R) certification from the U.S. Green ...
... should be vaccinated, experts urge, , MONDAY, June 29 (HealthDay ... than a million Americans sickened by the new swine flu, ... , Several articles published online Monday by the New ... the new H1N1 flu strain attacks younger people and can ...
... Association of Health Underwriters Elects Rusty Rice, Louanne Trebing, ... , AUSTIN, Texas, June 29 The Texas ... chapter of the National Association of Health Underwriters, has ... year. TAHU members Rusty Rice, Louanne Trebing, Joanna Antongiovanni ...
... , ... of the few surgeons in the Maryland specially trained to perform the latest minimally invasive ... ... Hungerford, M.D. has joined Mercy Medical Center as the 135-year-old downtown hospital,s ...
Cached Medicine News:Health News:Miami Physician Sentenced to 97 Months in Prison for Role in $10 Million Medicare Fraud Scheme 2Health News:Miami Physician Sentenced to 97 Months in Prison for Role in $10 Million Medicare Fraud Scheme 3Health News:HealthFitness Added to the Russell Microcap Index 2Health News:BioMed Realty Trust Completes $350 Million Financing for Center for Life Science Boston 2Health News:BioMed Realty Trust Completes $350 Million Financing for Center for Life Science Boston 3Health News:BioMed Realty Trust Completes $350 Million Financing for Center for Life Science Boston 4Health News:Younger People Appear More at Risk From New Swine Flu 2Health News:Younger People Appear More at Risk From New Swine Flu 3Health News:Younger People Appear More at Risk From New Swine Flu 4Health News:TAHU Takes on New Leadership During Vital Time in Health Insurance Industry 2Health News:Orthopedic Surgeon Dr. Marc W. Hungerford, a Leading Expert in Field of Avascular Necrosis, Now at Baltimore's Mercy Medical Center 2Health News:Orthopedic Surgeon Dr. Marc W. Hungerford, a Leading Expert in Field of Avascular Necrosis, Now at Baltimore's Mercy Medical Center 3
(Date:1/15/2014)... OAKS, Calif. , Jan. 15, 2014 /PRNewswire/ ... and Amgen (NASDAQ: AMGN ) announced ... to jointly discover and validate new therapeutic targets ... (IBD), a chronic disorder that affects millions worldwide. ... in clinical medicine, IBD biology, human genetics, genomic ...
(Date:1/15/2014)... -- BreedIT Corp (OTC: BRDT), through its ... highly sophisticated agro-breeding solutions for plant breeders and researchers, ... board of directors appointed chemistry and pharmaceutical industry expert ... of the board. From 1975 to 2012, ... Ltd (NYSE: TEVA ) and its subsidiaries ...
(Date:1/15/2014)... 15, 2014 Tegra Medical is very pleased ... King as its new Chief Executive Officer.  Mark ... Officer, in which he has overseen the company,s four ... Mississippi , and Costa Rica.  Mr. King joined ... operations, sales, engineering and manufacturing experience in medical device ...
Breaking Medicine Technology:Mass. General, Broad Institute and Amgen Will Work to Discover New Drugs for Inflammatory Bowel Disease 2Mass. General, Broad Institute and Amgen Will Work to Discover New Drugs for Inflammatory Bowel Disease 3Mass. General, Broad Institute and Amgen Will Work to Discover New Drugs for Inflammatory Bowel Disease 4BreedIT (OTC: BRDT) Appoints Chemistry and Pharmaceutical Industry Expert Dr. Ben-Zion Weiner to Its Board of Directors 2BreedIT (OTC: BRDT) Appoints Chemistry and Pharmaceutical Industry Expert Dr. Ben-Zion Weiner to Its Board of Directors 3Tegra Medical Appoints New Chief Executive Officer 2Tegra Medical Appoints New Chief Executive Officer 3
... CINCINNATI, Sept. 27, 2011 To further reduce ... Ethicon Endo-Surgery, Inc. (EES), announced today the launch ... the industry,s first powered endocutter with enhanced system-wide ... worldwide, Powered ECHELON FLEX™ allows greater instrument stability ...
... 2011 Thousands of jobs in Ohio supported by ... policies – such as imposing new taxes in the ... policymakers. From research to technical work, manufacturing ... child care services, the biopharmaceutical sector supports a broad ...
Cached Medicine Technology:Ethicon Endo-Surgery Introduces First Powered Endocutter with Enhanced System-Wide Compression and Stability, Allowing Surgeons Greater Control in Laparoscopic Surgery 2Ethicon Endo-Surgery Introduces First Powered Endocutter with Enhanced System-Wide Compression and Stability, Allowing Surgeons Greater Control in Laparoscopic Surgery 3Ethicon Endo-Surgery Introduces First Powered Endocutter with Enhanced System-Wide Compression and Stability, Allowing Surgeons Greater Control in Laparoscopic Surgery 4Research Demonstrates Possible Ohio Job Losses from Sectors Supported by Biopharmaceutical Companies 2Research Demonstrates Possible Ohio Job Losses from Sectors Supported by Biopharmaceutical Companies 3
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
Medicine Products: