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Sun-induced skin cancer: new discovery permits doctors to assess genetic risk
Date:6/2/2010

mount of DNA damage and the rate of its repair, as well as the percent of surviving melanocytes. Then the scientists inserted a normal version of the MC1R gene into the skin cells and found that they responded properly to ultraviolet light by producing the pigment necessary to protect themselves. These results give researchers testable strategies to reduce or prevent skin cancer. The results also suggest that it may be possible to develop drugs or a new generation of sunscreens that restore the lost function of MC1R.

"This research permits us know our own, personal risk for skin cancer." said Gerald Weissmann, M.D., Editor-in-Chief of The FASEB Journal. "We've known for a long time that smearing on sunscreen is the best way to avoid skin cancer, but never how much or what kind. This study points the way to new kinds of sunscreens that restore their skin's ability to protect itself from DNA damage."


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Contact: Cody Mooneyhan
cmooneyhan@faseb.org
301-634-7104
Federation of American Societies for Experimental Biology
Source:Eurekalert

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