Navigation Links
Sun-induced skin cancer: new discovery permits doctors to assess genetic risk
Date:6/2/2010

As people head to the beach this summer, very few if any, really know how likely they are to develop skin cancer from their outdoor fun. That's about to change, thanks to a new discovery by an international team of scientists that makes it possible for doctors to access people's personal risk for skin cancer.

In a new research report appearing online in The FASEB Journal (http://www.fasebj.org), these researchers describe for the first time the chain of molecular events that increase one's risk of skin cancer. This discovery may lead to new tests that access personal skin cancer risk as well as a new generation of sunscreens that increase the skin's ability to protect itself from the sun's damaging rays.

"Our study heralds the onset of personalized medicine for individuals who carry a change in the MC1R gene," said Zalfa A. Abdel-Malek, Ph.D., a researcher involved in the work from the Department of Dermatology at the University of Cincinnati. "The data we have obtained allows us to better predict which individuals will be at risk for skin cancer, as well as potentially why and to what degree. In the future, genetic testing for MC1R gene changes may be clinically available so that individuals can be made aware of the molecular basis of their risk prior to development of cancer."

Abdel-Malek and colleagues found that when a pigmentation gene called the "melanocortin 1 receptor" or MC1R does not function properly, skin cells do not respond to a hormone, called α-MSH, which causes cells to produce dark pigmentation to protect themselves from ultraviolet rays. To make this discovery, the researchers studied 21 human skin cell cultures that express the MC1R gene in different ways. Each culture was studied for expression of genetic changes of MC1R, pigment levels and the ability to respond to α-MSH. The researchers also exposed the cell cultures to ultraviolet rays and measured the amount of DNA damage and the rate of its repair, as well as the percent of surviving melanocytes. Then the scientists inserted a normal version of the MC1R gene into the skin cells and found that they responded properly to ultraviolet light by producing the pigment necessary to protect themselves. These results give researchers testable strategies to reduce or prevent skin cancer. The results also suggest that it may be possible to develop drugs or a new generation of sunscreens that restore the lost function of MC1R.

"This research permits us know our own, personal risk for skin cancer." said Gerald Weissmann, M.D., Editor-in-Chief of The FASEB Journal. "We've known for a long time that smearing on sunscreen is the best way to avoid skin cancer, but never how much or what kind. This study points the way to new kinds of sunscreens that restore their skin's ability to protect itself from DNA damage."


'/>"/>

Contact: Cody Mooneyhan
cmooneyhan@faseb.org
301-634-7104
Federation of American Societies for Experimental Biology
Source:Eurekalert

Related medicine news :

1. Pancreatic cancer: Minimally invasive treatments and possible links to GI diseases
2. Prostate cancer: Risk increases with the number of affected family members
3. Brain cancer: Study focuses on forgotten cells
4. Castrate-Metastatic Prostate Cancer: Therapeutic Considerations for Advanced Disease
5. Scanning for skin cancer: Infrared system looks for deadly melanoma
6. Personalizing cancer: Creating biomarkers from tumor DNA
7. Lung Cancer: Large Impact, Little Funding
8. Exposing the Double Standard of the Forgotten Cancer: Biggest Cancer Killer for Women and Men, Lung Cancer, Receives Least Research Funds
9. U of A discovery offers promising research for spinal-cord injury treatments
10. Discovery of Stem Cell Illuminates Human Brain Evolution, Points To Therapies
11. Gene discovery potential key to cost-competitive cellulosic ethanol
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/27/2016)... ... ... TopConsumerReviews.com recently awarded their highest five-star rating to Best Buy Eyeglasses, an ... United States and Canada wear eyeglasses. Once considered to be a purely functional part ... fashion statement. Even celebrities use glasses as a way of creating an iconic image—like ...
(Date:6/26/2016)... (PRWEB) , ... June 26, 2016 , ... On June ... sponsor of the 2016 Cereal Festival and World’s Longest Breakfast Table in Battle Creek, ... of the city’s history as home to some of the world’s leading providers of ...
(Date:6/26/2016)... ... , ... PawPaws brand pet supplements owned by Whole Health Supply ... health of felines. The formula is all-natural and is made from Chinese herbs that ... Cat Kidney Support Supplement Soft Chews are Astragalus Root Extract and Rehmannia Root ...
(Date:6/26/2016)... ... June 26, 2016 , ... Many women ... diagnosed with endometriosis. These women need a treatment plan to not only alleviate ... that can help for preservation of fertility and ultimately achieving a pregnancy. The ...
(Date:6/25/2016)... ... 25, 2016 , ... Austin residents seeking Mohs surgery services, can now turn ... to Dr. Russell Peckham for medical and surgical dermatology. , Dr. Dorsey brings specialization ... selective fellowship in Mohs Micrographic Surgery completed by Dr. Dorsey was under the direction ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... 23, 2016  MedSource announced today that it ... software solution of choice.  This latest decision demonstrates ... to their clients by offering a state-of-the-art electronic ... establishes nowEDC as the EDC platform of choice ... clients.  "nowEDC has long been a preferred EDC ...
(Date:6/23/2016)... DUBLIN , June 23, 2016 ... the "Pharmaceutical Excipients Market by Type (Organic Chemical ... Preservative), Formulation (Oral, Topical, Coating, Parenteral) - Global Forecast ... The global pharmaceutical excipients ... 2021 at a CAGR of 6.1% in the forecast ...
(Date:6/23/2016)... 23, 2016 Research and Markets has ... Market Analysis 2016 - Forecast to 2022" report to ... report contains up to date financial data derived from varied ... major trends with potential impact on the market during the ... segmentation which comprises of sub markets, regional and country level ...
Breaking Medicine Technology: