Navigation Links
Suicide Risk With Antidepressants Falls With Age
Date:8/11/2009

Study reiterates that young are most vulnerable

TUESDAY, Aug. 11 (HealthDay News) -- The U.S. Food and Drug Administration is doing its part to make sure that doctors and patients alike are aware of the latest data on the link between antidepressant use and suicide, which indicate that the risk declines steadily with age.

A review of 372 trials involving nearly 100,000 people who took antidepressants showed that the drugs increase the risk for suicide in people younger than 25, have no effect in those 25 to 64 and reduce risk in those 65 and older. A report on the findings is published online Aug. 12 in BMJ.

Information on the suicide risk linked to antidepressant use was posted on the FDA Web site some time ago, but "we thought it needed to be in a peer-reviewed publication, which would make it more useful to professionals," said Dr. Marc Stone, a senior medical reviewer in the agency's Center for Drug Evaluation and Research and lead author of the BMJ report.

The risk of suicide among younger users of antidepressant drugs became prominent in 2003, when the FDA cited studies showing such an increased risk of suicide attempts or suicide-related behavior among children and adolescents taking the widely used selective serotonin reuptake inhibitors (SSRIs), such as Zoloft, Celexa and Prozac.

A year later, the agency had the companies that market those drugs revise labeling to include a black-box warning so that health-care providers would be alert to any indication of suicide-related behavior in young users.

In 2006, analysis of the studies described in the new journal report led to a labeling change that expanded the warning to young adults.

The studies show "a bigger picture, where we see a declining rate in older patients that is essentially zero in middle-age adults, and suggest a beneficial effect which lowers the risk of suicidal thoughts in older people," Stone said.

The analysis revealed eight completed suicides, 134 suicide attempts and 378 instances of suicidal thoughts that did not lead to action. The odds ratio for suicidal behavior declined at a rate of 4.6 percent for every year of age, according to the study.

The report was criticized by Dr. John Geddes, a professor of epidemiological psychiatry at the University of Oxford in England and a co-author of an accompanying editorial in BMJ, who said it relied too much on data from trials sponsored by drug companies.

"In these trials, they compare a drug with a placebo," Geddes said. A placebo is an inactive substance. "These are hard trials to do so they exclude people who are very ill," he said. Because of this, he said, "they can't possibly observe how the drugs affect such people."

"One of the things that we need to be clear about is that we can't rely on placebo-control trials of new medications done by the industry," Geddes said. "They can't answer all the clinical questions. We need more active comparison trials which don't have placebo in them and larger trials aimed at antidepressants in clinical practice."

Geddes also criticized the report for lumping together all SSRIs. "Sometimes people are wary of saying that one drug is safer than another drug in the same class," he said.

But, he said, the studies indicate that suicide risk varies widely among SSRIs. "Sertraline is best in terms of tolerability," he said.

Studies cited in the report indicate that sertraline, the generic name for Zoloft, carries only half the risk for suicidal thoughts and behavior of some other SSRIs, Geddes said.

More information

The U.S. Food and Drug Administration has more on antidepressants.



SOURCES: Marc Stone, M.D., senior medical reviewer, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Bethesda, Md.; John Geddes, M.D., professor, epidemiological psychiatry, University of Oxford, England; Aug. 12, 2009, BMJ, online


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Suicide Genes Help Slow Ovarian Tumor Growth in Mice
2. Nanoparticle-delivered 'Suicide' Genes Slowed Ovarian Tumor Growth
3. Feeling Blue Suicide Prevention Council Partners With the National Institute of Mental Health
4. Financial crisis increases suicides and homicides
5. VAs Suicide Prevention Message Carried on 21,000 Buses
6. Almost Quarter of Suicides Involve Intoxication
7. Sedatives Increase Suicide Risk Among Elderly
8. Fred A. Baughman Jr., MD Announces: Vets Sudden Cardiac Deaths Are Not Suicides or Overdoses
9. Worries About Weight Are Tied to Teen Suicide Tries
10. Americans United for Life Represents 28 Bipartisan Montana Legislators Arguing Assisted Suicide Not a Right
11. Team Uncovers Discrepancy in Death Certificates Listing Suicide
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Suicide Risk With Antidepressants Falls With Age 
(Date:4/26/2017)... ... April 26, 2017 , ... CareSet Labs today ... e-prescribing as measured in Part D Medicare data. The dataset, called PaPR (Providers ... using e-prescribing, faxes or paper. The PaPR (pronounced "paper") data set aggregates ...
(Date:4/26/2017)... ... 2017 , ... The National Business Research Institute (NBRI) is ... Emergency Medical Technicians and welcomes this organization to the NBRI Circle of ... Ph.D. , CEO & Organizational Psychologist at NBRI. “This award is a result ...
(Date:4/26/2017)... City, NJ (PRWEB) , ... April 26, 2017 , ... ... offers an easy way to get nutrients from SUPERFOODS! , RawTrition is ... body at the cellular level because the body recognizes its raw form (unlike the ...
(Date:4/26/2017)... (PRWEB) , ... April 26, ... ... which provides an agile ecosystem and domain expertise for sponsors and CROs ... randomization and trial supply management (RTSM) software platform. Bioclinica AGILE RTSM ...
(Date:4/25/2017)... ... 25, 2017 , ... Splashtop Inc. , the worldwide ... new addition to the Mirroring360 product family combines device screen mirroring with screen ... enables educators, business professionals and individuals to stream or mirror app screens, music, ...
Breaking Medicine News(10 mins):
(Date:4/18/2017)... Viverae ® , a leader in workplace ... IBM ® Watson Campaign Automation, implementing behavioral messaging ... a personalized experience. Through digital engagement, the platform prompts ... real time. The enhanced experience drives engagement by focusing ... they are in their journey to health. ...
(Date:4/18/2017)... , April 18, 2017  Astute Medical, Inc., developer ... series to be presented at the 2017 National Kidney ... today and continues through April 22. Physicians will present ... used to assess risk for acute kidney injury (AKI) ... failure (ADHF). Elevated levels of TIMP-2 ...
(Date:4/18/2017)... 18, 2017  Socionext Inc. and SOINN Inc. ... 2016, in which Socionext extracts and delivers biometrics ... achieved initial results in reading ultrasound images from ... SOINN. The results will be introduced at Medtec ... at booths 4505 & 4507. In ...
Breaking Medicine Technology: