Navigation Links
Sugar overload can damage heart according to UTHealth research
Date:6/14/2013

HOUSTON (June 14, 2013) Too much sugar can set people down a pathway to heart failure, according to a study led by researchers at The University of Texas Health Science Center at Houston (UTHealth).

A single small molecule, the glucose metabolite glucose 6-phosphate (G6P), causes stress to the heart that changes the muscle proteins and induces poor pump function leading to heart failure, according to the study, which was published in the May 21 issue of the Journal of the American Heart Association. G6P can accumulate from eating too much starch and/or sugar.

Heart failure kills 5 million Americans a year, according to the Centers for Disease Control. The one-year survival rate after diagnosis is 50 percent and there are 550,000 new patients in the United States diagnosed with heart failure each year.

"Treatment is difficult. Physicians can give diuretics to control the fluid, and beta-blockers and ACE inhibitors to lower the stress on the heart and allow it to pump more economically," said Heinrich Taegtmeyer, M.D., D.Phil., principal investigator and professor of cardiology at the UTHealth Medical School. "But we still have these terrible statistics and no new treatment for the past 20 years."

Taegtmeyer performed preclinical trials in animal models, as well as tests on tissue taken from patients at the Texas Heart Institute who had a piece of the heart muscle removed in order to implant a left ventricle assist device by O.H. "Bud" Frazier, M.D., and his team. Both led to the discovery of the damage caused by G6P.

"When the heart muscle is already stressed from high blood pressure or other diseases, and then takes in too much glucose, it adds insult to injury," Taegtmeyer said.

The study has opened doors to possible new treatments. Two drugs, rapamycin (an immunosuppressant) and metformin (a diabetes medication) disrupt signaling of G6P and improved cardiac power in small animal studies.

"T
'/>"/>

Contact: Deborah Lake
deborah.m.lake@uth.tmc.edu
713-500-3304
University of Texas Health Science Center at Houston
Source:Eurekalert

Page: 1 2

Related medicine news :

1. National Alliance For Hispanic Health Leads Diverse “Friends of the Court” in Support of NYC Policy to Reduce Sugary Drink Portion Size
2. Depression May Raise Low Blood Sugar Risk in Diabetics
3. Sugar Injections for Knee Arthritis May Ease Pain: Study
4. Sugary Sodas, Fruit Punches May Raise Kidney Stone Risk: Study
5. Novel study reports marijuana users have better blood sugar control
6. INH’s Essential BioNutrients Announces Launch of Blood Sugar Support Supplement – GlucoGold
7. High Blood Sugar May Add to Alzheimers Risk: Study
8. University Finds that Lifting Weights May Lower Blood Sugar Levels, Suggesting that Supplements Like Prescopodene May Assist By Creating More Energetic Exercise Sessions
9. Mother’s Mountain Sponsors 31st Annual Sugarloaf Marathon
10. Study shows so-called cougars, sugar daddies more myth than reality
11. Younger Men Biggest Consumers of Added Sugars: CDC
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)... Gabe’s Chemo Duck Program is pleased to announce ... ever created for kids with cancer. The Chemo Duck App, available ... filled with enjoyable games to help children of all ages living ... helps to keep kids entertained, educated and at ease while waiting ...
(Date:1/22/2015)... a seasoned and trusted leader who consistently delivers trendy dresses ... it lead the wedding dress industry into the future. Today, ... the global market. , “The CEO of VogueQueen is uniquely ... continuing the goal of operational excellence and giving back to ...
(Date:1/22/2015)... 2015 Angelweddingdress is a famous wedding dress ... customers to follow it on Facebook, Twitter, and Pinterest. The ... gift. Angelweddingdress draws a lottery every week. , Moreover, the ... 28, 2015. Click Angelweddingdress homepage for more information. ...
(Date:1/22/2015)... AngelWeddingDress, the premier women’s dress supplier, has recently ... View website of AngelWeddingDress.com to find more details. ... online for a bridal party. AngelWeddingDress offers a variety ... Its maternity wedding dresses are specially designed for 2015. ...
(Date:1/22/2015)... Florida (PRWEB) January 22, 2015 Juvent ... today at the 2015 PGA Merchandise Show to bestow ... and incredible female amateur golfer, Arlene McKitrick. The award ... female amateur golf tournament win. She won her first ...
Breaking Medicine News(10 mins):Health News:Chemo Duck Launches First App Ever Created for Kids with Cancer 2Health News:Chemo Duck Launches First App Ever Created for Kids with Cancer 3Health News:VogueQueen Unveils New Designs of Prom Dresses for 2015 2Health News:Angelweddingdress Invites Its Customers To Follow It On Facebook, Twitter, And Pinterest 2Health News:AngelWeddingDress Has Recently Released Its Collection Of 2015 Maternity Wedding Dresses 2Health News:All-Time Leading Female Amateur Golfer Arlene McKitrick Receives Juvent Sports Achievement Award at 2015 PGA Show 2Health News:All-Time Leading Female Amateur Golfer Arlene McKitrick Receives Juvent Sports Achievement Award at 2015 PGA Show 3
... FRANCISCO, Feb. 19 California attorneys and a,presiding judge ... notables,that will assemble next month in Los Angeles to ... , Robert Berkes of Berkes ... an,insurer,s perspective on asbestos litigation; Steven Kazan of Kazan ...
... WINNIPEG, Feb. 19 /PRNewswire-FirstCall/ - IMRIS Inc. (TSX: ... five-year research initiative to focus on the development ... procedures, working with the University Health Network (UHN) ... of IMRIS into the field of image guided ...
... Champion for BabiesNEW YORK, Feb. 19 The March of Dimes ... MVP, Eli Manning , will return for a second year, to ... will be joined by CBS 2 News Co-Anchor, Maurice DuBois ... who will co-host the morning program. "I,m very excited to be ...
... linked to risk-taking, too, study finds, , , THURSDAY, ... that makes people love skydiving, mountain-climbing or other ... of the brain that has been linked to ... University researchers studied volunteers who were grouped as ...
... transplanting stem cells from the patient,s own bone marrow is an ... , The procedure has been tested successfully in the US ... in 80% of cases, and considerable improvement in quality of life ... has used this therapy in a total of 6 patients. ...
... Children,s Hospital and Salvation Army Receive Top Awards In January; ... the Fight Against Breast Cancer and Wounded WarriorsWHITE PLAINS, N.Y., ... for change appear to have extended all the way to ... on to IWON.com last month to play games on behalf ...
Cached Medicine News:Health News:California Attorneys Featured at Major Asbestos Litigation Event 2Health News:IMRIS announces development program for MR guided radiation and interventional applications 2Health News:Eli Manning to Lead March for Babies(R) in Manhattan 2Health News:Thrill-Seekers' Brains May Be Wired Differently 2Health News:New therapy with stem cells to treat Crohn's disease 2Health News:New therapy with stem cells to treat Crohn's disease 3Health News:New therapy with stem cells to treat Crohn's disease 4Health News:New therapy with stem cells to treat Crohn's disease 5Health News:Casual Gamers Join Forces With Top Charities to Compete for IWON.com Cash Prizes 2Health News:Casual Gamers Join Forces With Top Charities to Compete for IWON.com Cash Prizes 3
(Date:1/22/2015)...  Uroplasty, Inc. (NASDAQ: UPI ), a medical device ... to treat voiding dysfunctions, today reported financial results for ... Global revenue for the Company,s Urgent ®  PC ... quarterly revenue record, as compared to $3.9 million in ...
(Date:1/22/2015)... Corporation (NASDAQ: TECH ) announced today that ... new Simple Plex platform through its Proteins Platform division ... of the previously acquired CyPlex instrument platform from CyVek. ... immunoassay technology which integrates an innovatively designed microfluidic cartridge ...
(Date:1/22/2015)... Research and Markets ( http://www.researchandmarkets.com/research/x3hp3g/microbiology ) ... Testing/Clinical Microbiology Market by Product, Clinical Application & ... report to their offering. Clinical microbiology ... the detection of infectious diseases. The respiratory diseases ...
Breaking Medicine Technology:Uroplasty Reports Record Revenue in Fiscal Third Quarter 2Uroplasty Reports Record Revenue in Fiscal Third Quarter 3Uroplasty Reports Record Revenue in Fiscal Third Quarter 4Uroplasty Reports Record Revenue in Fiscal Third Quarter 5Uroplasty Reports Record Revenue in Fiscal Third Quarter 6Uroplasty Reports Record Revenue in Fiscal Third Quarter 7Uroplasty Reports Record Revenue in Fiscal Third Quarter 8Uroplasty Reports Record Revenue in Fiscal Third Quarter 9Uroplasty Reports Record Revenue in Fiscal Third Quarter 10Uroplasty Reports Record Revenue in Fiscal Third Quarter 11Uroplasty Reports Record Revenue in Fiscal Third Quarter 12Uroplasty Reports Record Revenue in Fiscal Third Quarter 13Uroplasty Reports Record Revenue in Fiscal Third Quarter 14Uroplasty Reports Record Revenue in Fiscal Third Quarter 15Uroplasty Reports Record Revenue in Fiscal Third Quarter 16Uroplasty Reports Record Revenue in Fiscal Third Quarter 17Uroplasty Reports Record Revenue in Fiscal Third Quarter 18Bio-Techne Launches Simple Plex Platform 2Bio-Techne Launches Simple Plex Platform 3Global Microbiology Testing/Clinical Microbiology (Instrument, Analyzer, Incubator, Kit, Microscope, Molecular Diagnostics) Market - Forecast to 2019 2Global Microbiology Testing/Clinical Microbiology (Instrument, Analyzer, Incubator, Kit, Microscope, Molecular Diagnostics) Market - Forecast to 2019 3
... ANNAPOLIS, Md. , July 30 PharmAthene, Inc. ... developing medical countermeasures against biological and chemical threats, today announced that ... the NYSE Amex LLC, stating that PharmAthene is not in compliance ... (iii) of the NYSE Amex Company Guide, because it has stockholders, ...
... SAN DIEGO , July 30 CareFusion Corporation (NYSE: ... Tuesday, Aug. 10 following the close of trading on the New York Stock Exchange. ... The company will host a webcast and conference ... p.m. Eastern time ) to discuss the results for its fourth quarter and fiscal 2010, ...
Cached Medicine Technology:PharmAthene Provides Update on NYSE Amex Listing Compliance Plan 2PharmAthene Provides Update on NYSE Amex Listing Compliance Plan 3CareFusion Will Host an Earnings Conference Call on Aug. 10 to Discuss the Results for the Fourth Quarter and Fiscal 2010 2
Facial Mask...
Abdominal Binders - 9" & 12"...
Ideal for abdominal and flank procedures....
CDIs 2nd Stage Abdominoplasty Girdle - a feminine, easy pull-on version of the 8000 series...
Medicine Products: