Navigation Links
Sugar-coated antibiotics
Date:5/28/2008

Researchers from the John Innes Centre and the University of East Anglia have recently elucidated the structure and function of an enzyme which is involved in decorating antibiotics with sugar molecules. Many antibiotics have a variety of different carbohydrate molecules attached to them which can help the antibiotic to be taken up by the target organism or overcome resistance. By manipulating the sugar, it may be possible to restore usefulness in antibiotics to which resistance has developed.

The aim of this research was to find out how these sugars are made, and how their structures affect their biological activity. The researchers studied an enzyme from a little studied species of Streptomyces bacteria, which produces the antibiotic tylosin. The enzyme they looked at is involved in making a sugar molecule that decorates tylosin. By working out how the carbohydrates are made, it may be possible to make unnatural sugars, with different properties.

This is a bit of biochemistry we cant do with chemistry. We need to go back to the fundamentals of how these sugars are put together in nature, said Professor Rob Field. We want to see what happens when we decorate an antibiotic with sugar and which sugars make the best decoration.

They are not yet near to a market product, but trying to understand at a fundamental level how these sugars are made. We are still putting the toolkit together said Professor Field. By modelling the enzyme, and comparing it with related enzymes, they have been able to identify the key parts needed for its function, and propose the biochemical basis for how it creates the carbohydrates precise structure.


'/>"/>

Contact: Andrew Chapple
andrew.chapple@bbsrc.ac.uk
01-603-251-490
Norwich BioScience Institutes
Source:Eurekalert

Page: 1

Related medicine news :

1. Gator Blood May Be New Source of Antibiotics
2. Green Tea Boosts Antibiotics for Superbugs
3. Dont Prescribe Antibiotics for Adult Sinus Woes
4. Synthetic peptoids hold forth promise for new antibiotics
5. Biannual Antibiotics May Cut Major Cause of Blindness in Africa
6. Antibiotics Do Little for Inner Ear Infections
7. DNA with a twist: New company to search for cancer drugs and antibiotics
8. Advanced Life Sciences to Participate in Antibiotics Expert Panel at the 10th Annual BIO CEO & Investor Conference
9. Antibiotics May Not Help Mens Chronic Pelvic Pain: Harvard Doctors Discuss Alternatives
10. Ear infection superbug discovered to be resistant to all pediatric antibiotics
11. Antibiotics Not Always Best Bet for Battling Childhood Ear Infections
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/4/2016)... ... 04, 2016 , ... Warren L. Smith M.D. , There is a new ... plagued people since the beginning of recorded medical history, and in spite of all ... not just a matter of inconvenience; bladder infections cost us billions of dollars annually ...
(Date:5/4/2016)... ... May 04, 2016 , ... With the stamp of approval from the ... May as National Cancer Research Month. According to the American Cancer Society (2016) ... predications of one in four Americans dying as a result. , With numbers as ...
(Date:5/4/2016)... (PRWEB) , ... May 04, 2016 , ... Fertility Centers ... at 535 Ocean Ave. Their new Maine Fertility Center provides convenient access to care ... Anne Rainville and her staff at Women’s Wellness Comprehensive Care in Portland,” said Fertility ...
(Date:5/4/2016)... ... ... Netc , a leading provider of barcode and RFID labels has ... Netc to continue to grow its label business, customer base and market share. , ... to print and label tape media on site and on an as needed basis. Many ...
(Date:5/3/2016)... ... May 04, 2016 , ... The National Association of Professional Women (NAPW) ... of the Year Circle. She is recognized with this prestigious distinction for leadership in ... than 850,000 members and over 200 operating Local Chapters. , “I’m pleased to welcome ...
Breaking Medicine News(10 mins):
(Date:5/3/2016)... , May 3, 2016   Diplomat Pharmacy, Inc. (NYSE: DPLO) announced today that it is ... a video of two patients who tell their personal story and encourage those at risk ... Meet Jacque: Hepatitis C ... ... Diplomat Specialty Pharmacy (PRNewsFoto/Diplomat Pharmacy, Inc.) ...
(Date:5/3/2016)... , May 3, 2016 ... Market Size, Share, Development, Growth and Demand Forecast to ... by Field Strength (High Field, Very High Field, Low ... (Brain, Head and Neck, Spine, Musculoskeletal, Vascular, Breast, Pelvic ... global magnetic resonance imaging (MRI) market was valued at ...
(Date:5/3/2016)... , May 3, 2016 ... INTP), a clinical-stage biopharmaceutical company, today announced the appointment ... and Regulatory Affairs. "Ms. Strauss-Levy has 15 ... and has established an outstanding track record, having supported ... and regulatory approval processes in the United ...
Breaking Medicine Technology: