Navigation Links
Sugar-coated antibiotics
Date:5/28/2008

Researchers from the John Innes Centre and the University of East Anglia have recently elucidated the structure and function of an enzyme which is involved in decorating antibiotics with sugar molecules. Many antibiotics have a variety of different carbohydrate molecules attached to them which can help the antibiotic to be taken up by the target organism or overcome resistance. By manipulating the sugar, it may be possible to restore usefulness in antibiotics to which resistance has developed.

The aim of this research was to find out how these sugars are made, and how their structures affect their biological activity. The researchers studied an enzyme from a little studied species of Streptomyces bacteria, which produces the antibiotic tylosin. The enzyme they looked at is involved in making a sugar molecule that decorates tylosin. By working out how the carbohydrates are made, it may be possible to make unnatural sugars, with different properties.

This is a bit of biochemistry we cant do with chemistry. We need to go back to the fundamentals of how these sugars are put together in nature, said Professor Rob Field. We want to see what happens when we decorate an antibiotic with sugar and which sugars make the best decoration.

They are not yet near to a market product, but trying to understand at a fundamental level how these sugars are made. We are still putting the toolkit together said Professor Field. By modelling the enzyme, and comparing it with related enzymes, they have been able to identify the key parts needed for its function, and propose the biochemical basis for how it creates the carbohydrates precise structure.


'/>"/>

Contact: Andrew Chapple
andrew.chapple@bbsrc.ac.uk
01-603-251-490
Norwich BioScience Institutes
Source:Eurekalert

Page: 1

Related medicine news :

1. Gator Blood May Be New Source of Antibiotics
2. Green Tea Boosts Antibiotics for Superbugs
3. Dont Prescribe Antibiotics for Adult Sinus Woes
4. Synthetic peptoids hold forth promise for new antibiotics
5. Biannual Antibiotics May Cut Major Cause of Blindness in Africa
6. Antibiotics Do Little for Inner Ear Infections
7. DNA with a twist: New company to search for cancer drugs and antibiotics
8. Advanced Life Sciences to Participate in Antibiotics Expert Panel at the 10th Annual BIO CEO & Investor Conference
9. Antibiotics May Not Help Mens Chronic Pelvic Pain: Harvard Doctors Discuss Alternatives
10. Ear infection superbug discovered to be resistant to all pediatric antibiotics
11. Antibiotics Not Always Best Bet for Battling Childhood Ear Infections
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/26/2016)... ... June 26, 2016 , ... Many women ... diagnosed with endometriosis. These women need a treatment plan to not only alleviate ... that can help for preservation of fertility and ultimately achieving a pregnancy. The ...
(Date:6/25/2016)... ... June 25, 2016 , ... The temporary closing of Bruton Memorial Library on June 21 due ... up a new, often overlooked aspect of head lice: the parasite’s ability to live away ... a common occurrence, but a necessary one in the event that lice have simply gotten ...
(Date:6/25/2016)... ... 2016 , ... As a lifelong Southern Californian, Dr. Omkar Marathe earned his ... David Geffen School of Medicine at UCLA. He trained in Internal Medicine at Scripps ... in hematology/oncology at the UCLA-Olive View-Cedars Sinai program where he had the opportunity to ...
(Date:6/25/2016)... ... , ... Conventional wisdom preaches the benefits of moderation, whether it’s a matter ... bar too high can result in disappointment, perhaps even self-loathing. However, those who set ... , Research from PsychTests.com reveals that behind the tendency to set low ...
(Date:6/24/2016)... ... June 24, 2016 , ... June 19, 2016 is ... associated with chronic pain and the benefits of holistic treatments, Serenity Recovery Center ... suffering with Sickle Cell Disease. , Sickle Cell Disease (SCD) is a disorder of ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... and SAN CLEMENTE, Calif. , June 24, ... -based mobile pulmonary function testing company, is now able to perform ... developed by ndd Medical Technologies , Inc. ... in hospital-based labs.  Thanks to ndd,s EasyOne PRO ® , ARL ... can get any needed testing done in the comfort of her ...
(Date:6/24/2016)... Tenn. , June 24, 2016  Arkis ... providing less invasive and more durable cerebrospinal fluid ... in funding.  The Series-A funding is led by ... Lighthouse Fund, and other private investors.  Arkis, new ... neurosurgical instrumentation and the market release of its ...
(Date:6/23/2016)... -- In a startling report released today, National Safety Council ... comprehensive, proven plan to eliminate prescription opioid overdoses. Prescription ... are tackling the worst drug crisis in recorded U.S. history, assigned ... Kentucky , New Mexico , ... 28 failing states, three – Michigan , ...
Breaking Medicine Technology: