Navigation Links
Sugar-coated antibiotics
Date:5/28/2008

Researchers from the John Innes Centre and the University of East Anglia have recently elucidated the structure and function of an enzyme which is involved in decorating antibiotics with sugar molecules. Many antibiotics have a variety of different carbohydrate molecules attached to them which can help the antibiotic to be taken up by the target organism or overcome resistance. By manipulating the sugar, it may be possible to restore usefulness in antibiotics to which resistance has developed.

The aim of this research was to find out how these sugars are made, and how their structures affect their biological activity. The researchers studied an enzyme from a little studied species of Streptomyces bacteria, which produces the antibiotic tylosin. The enzyme they looked at is involved in making a sugar molecule that decorates tylosin. By working out how the carbohydrates are made, it may be possible to make unnatural sugars, with different properties.

This is a bit of biochemistry we cant do with chemistry. We need to go back to the fundamentals of how these sugars are put together in nature, said Professor Rob Field. We want to see what happens when we decorate an antibiotic with sugar and which sugars make the best decoration.

They are not yet near to a market product, but trying to understand at a fundamental level how these sugars are made. We are still putting the toolkit together said Professor Field. By modelling the enzyme, and comparing it with related enzymes, they have been able to identify the key parts needed for its function, and propose the biochemical basis for how it creates the carbohydrates precise structure.


'/>"/>

Contact: Andrew Chapple
andrew.chapple@bbsrc.ac.uk
01-603-251-490
Norwich BioScience Institutes
Source:Eurekalert

Page: 1

Related medicine news :

1. Gator Blood May Be New Source of Antibiotics
2. Green Tea Boosts Antibiotics for Superbugs
3. Dont Prescribe Antibiotics for Adult Sinus Woes
4. Synthetic peptoids hold forth promise for new antibiotics
5. Biannual Antibiotics May Cut Major Cause of Blindness in Africa
6. Antibiotics Do Little for Inner Ear Infections
7. DNA with a twist: New company to search for cancer drugs and antibiotics
8. Advanced Life Sciences to Participate in Antibiotics Expert Panel at the 10th Annual BIO CEO & Investor Conference
9. Antibiotics May Not Help Mens Chronic Pelvic Pain: Harvard Doctors Discuss Alternatives
10. Ear infection superbug discovered to be resistant to all pediatric antibiotics
11. Antibiotics Not Always Best Bet for Battling Childhood Ear Infections
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/13/2016)... ... ... Cypress in Sun City is the place to be on March 3rd to learn about ... will be hosting this educational seminar from 5:30 p.m. – 7:00 p.m. Exciting advancements will ... offers. In addition, prizes will be given away and light refreshments will be served. ...
(Date:2/13/2016)... ... February 13, 2016 , ... With FCPX Overlay Embers from Pixel Film Studios ... Cut Pro X. Each user can select from up to 40 effect overlays. With ... focus offset, hue, saturation, value, contrast, glow, and more all within a click of ...
(Date:2/13/2016)... Lake City, Utah (PRWEB) , ... February 13, 2016 , ... When an Au ... Host Parents aren’t always sure what they are in for and they are often worried ... are more than they were hoping for. This year’s Au Pair of the Year winner’s ...
(Date:2/12/2016)... ... February 12, 2016 , ... Mystic Buddha Publishing House presents Valentine’s Day tips ... biography of Rama - Dr. Frederick Lenz. , According to Publisher Roger ... Buddhist teacher for teaching and helping others. Valentine’s Day celebrates love in all ...
(Date:2/12/2016)... ... ... Enforcement Trends: , Back to the Future , Feb. 25, 2016 — 11:00 a.m. – ... who don’t learn from history are doomed to repeat it.” , An analysis of CDRH’s ... But that takes time. , Take a close look at the warning letters the ...
Breaking Medicine News(10 mins):
(Date:2/12/2016)... Maharashtra, February 12, 2016 ... report titled Chronic Inflammation Global Clinical Trials Review, ... of the global clinical trials landscape along with ... by Region, Country (G7 & E7), Trial Status, ... and reviews top companies involved and enlists all ...
(Date:2/11/2016)... Laboratory glassware and plasticware include ... may range from microscope slides to large storage boxes ... borosilicate glass because of its low weight and resistance ... started gaining popularity over the past decade when it ... with plastic in several applications due to its resistance ...
(Date:2/11/2016)... 11, 2016 Potrero Medical, Inc., the developer of ... the appointment of George M. Rapier, III , MD, ... TX , WellMed is one of the nation,s largest ... HMO members in Texas and ... of his own internal medicine practice, he has been instrumental ...
Breaking Medicine Technology: