Navigation Links
Suffocating tumors could lead to new cancer drugs
Date:7/25/2013

Scientists have discovered a new molecule that prevents cancer cells from responding and surviving when starved of oxygen and which could be developed into new treatments for the disease, according to new research published in the Journal of the American Chemical Society* today (Friday).

Cancer Research UK scientists at the University of Southampton found that this molecule targets the master switch -- HIF-1 -- that cancer cells use to adapt to low oxygen levels, a common feature in the disease.

The researchers uncovered a way to stop cancer cells using this switch through an approach called 'synthetic biology'. By testing 3.2 million potential compounds, made by specially engineered bacteria, they were able to find a molecule that stopped HIF-1 from working.

All cells need a blood supply to provide them with the oxygen and nutrients they require to survive. Cancer tumours grow rapidly and as the tumour gets bigger it outstrips the supply of oxygen and nutrients that the surrounding blood vessels can deliver.

But, to cope with this low-oxygen environment, HIF-1 acts as a master switch that turns on hundreds of genes, allowing cancer cells to survive. HIF-1 triggers the formation of new blood vessels around tumours, causing more oxygen and nutrients to be delivered to the starving tumour, which in turn allows it to keep growing.

Dr Ali Tavassoli, a Cancer Research UK scientist whose team discovered and developed the compound at the University of Southampton, said: "We've found a way to target the steps that cancer cells take to survive and we hope that our research will one day lead to effective drugs that can stop cancers adapting to a low oxygen environment, stopping their growth. The next step is to further develop this molecule to create an effective treatment."

Dr Julie Sharp, senior science information manager at Cancer Research UK, said: "Finding ways to disrupt the tools that cancer cells use
'/>"/>

Contact: Becky Attwood
r.attwood@soton.ac.uk
44-023-805-95457
University of Southampton
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Protein complex linked to cancer growth may also help fight tumors, Moffitt researchers say
2. Voices Against Brain Cancer Comments on Discovery of Nano Drug That May Aid in Treatment of Brain Tumors
3. Compounds outsmart solid tumors malfunctioning machinery
4. Suspicions confirmed: Brain tumors in children have a common cause
5. Therapy that heats and destroys bone tumors eases patients pain
6. New drug improves progression-free survival, shrinks tumors in rare cancer for first time
7. Many solid tumors carry genetic changes targeted by existing compounds
8. Immune system to fight brain tumors
9. Modified Polio Virus May Help Fight Brain Tumors, Study Suggests
10. Study details genes that control whether tumors adapt or die when faced with p53 activating drugs
11. Genetic diversity within tumors predicts outcome in head and neck cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/23/2014)... to better treating the pernicious disorders of obesity and ... from American University,s Center for Behavioral Neuroscience. In the ... therapies aimed at areas of the brain responsible for ... hippocampus could play a role in reducing certain dementias., ... preventive measures often fall short. This is a new ...
(Date:7/23/2014)... Kathleen Doheny ... News) -- Weight-loss surgery appears to have an additional ... in women, according to a new study. The ... weight-loss surgery program reported having incontinence prior to the ... urinary symptoms either improved or disappeared, said study researcher ...
(Date:7/23/2014)... BOSTON In a massive effort to catalog ... researchers at Dana-Farber Cancer Institute, have identified four ... other molecular abnormalities. They say the new classification ... therapies for the third-leading cancer killer worldwide. , ... of The Cancer Genome Atlas Research Network said ...
(Date:7/23/2014)... Arbor, MI (PRWEB) July 23, 2014 ... Real Madrid vs. Manchester United tickets at Michigan Stadium . ... Guinness International Champions Cup will be held at the Big ... University of Michigan Wolverines, will be home to a game ... Madrid from La Liga. The game will be held on ...
(Date:7/23/2014)... (PRWEB) July 23, 2014 Ticket Down ... AS Roma tickets in Dallas, TX at the Cotton ... team tournament held in the United States and Canada beginning ... world including teams from La Liga, Serie A, English Premier ... are Manchester United, Manchester City, Olympiacos, Inter Milan, Liverpool, AS ...
Breaking Medicine News(10 mins):Health News:Targeting the brain to treat obesity 2Health News:Targeting the brain to treat obesity 3Health News:Weight Loss Surgery May Help Ease Urinary Incontinence 2Health News:Weight Loss Surgery May Help Ease Urinary Incontinence 3Health News:New view of stomach cancer could hasten better therapies 2Health News:New view of stomach cancer could hasten better therapies 3Health News:Real Madrid vs. Manchester United Tickets Ann Arbor: Ticket Down Slashes Ticket Prices for ManU vs. Real Madrid Guinness International Champions Cup Tickets 2Health News:Real Madrid vs. Manchester United Tickets Ann Arbor: Ticket Down Slashes Ticket Prices for ManU vs. Real Madrid Guinness International Champions Cup Tickets 3Health News:Real Madrid vs. AS Roma Tickets Cotton Bowl Dallas, TX: Ticket Down Slashes Ticket Prices on all AS Roma vs. Real Madrid International Champions Cup Tickets 2Health News:Real Madrid vs. AS Roma Tickets Cotton Bowl Dallas, TX: Ticket Down Slashes Ticket Prices on all AS Roma vs. Real Madrid International Champions Cup Tickets 3
... THERAPIST LEADERS PROVIDE ANALYSIS OF PRESIDENTIAL CANDIDATES,HEALTH CARE ... Americans head,to the polls to cast their votes ... priority; approximately one in three Americans report having,trouble ... crisis and a,shortage of adequate, affordable health insurance ...
... increasingly higher doses of milk over time may ease, ... according to the results of a study led by ... Duke University. , Despite the small number of ... are illuminating and encouraging, investigators say, because this is ...
... Oct. 30 The American Society,for Therapeutic Radiology and ... September 21-25, 2008, at the Boston Convention and,Exhibition Center ... --,a 714 person and 4,900 square feet increase over ... square footage are also,all-time highs for an ASTRO Annual ...
... Services,Inc. (NYSE: AHS ) today announced operating results for the ... million, up 5% over last year and 1% over last quarter ... Revenue growth primarily driven by year-over-year volume increases in ... Locum Tenens. -- EPS of $0.28, up 12% over last ...
... Oct. 30 Kansas State,University and the Kansas ... new venture, "One Health Kansas," will promote,awareness and ... health., The Kansas State University Foundation accepted ... three years for a total of $2,292,308., ...
... 30 Physicians Healthcare,Management Group, Inc. (Phyhealth) (Pink ... in partnership with physicians,today announced that it has ... 30, 2008. The financials are being posted today ... its updated financials, Phyhealth expects to,qualify for the ...
Cached Medicine News:Health News:APTA Podcast Helps Voters Make Informed Decisions on Presidential Candidates' Health Care Plans 2Health News:APTA Podcast Helps Voters Make Informed Decisions on Presidential Candidates' Health Care Plans 3Health News:Drinking milk to ease milk allergy? 2Health News:Drinking milk to ease milk allergy? 3Health News:Premier Radiation Oncology Meeting Breaks Attendance, Exhibit Space Record at Boston Meeting 2Health News:AMN Healthcare Announces Third Quarter 2008 Results and Updates Full Year Guidance 2Health News:AMN Healthcare Announces Third Quarter 2008 Results and Updates Full Year Guidance 3Health News:AMN Healthcare Announces Third Quarter 2008 Results and Updates Full Year Guidance 4Health News:AMN Healthcare Announces Third Quarter 2008 Results and Updates Full Year Guidance 5Health News:AMN Healthcare Announces Third Quarter 2008 Results and Updates Full Year Guidance 6Health News:AMN Healthcare Announces Third Quarter 2008 Results and Updates Full Year Guidance 7Health News:AMN Healthcare Announces Third Quarter 2008 Results and Updates Full Year Guidance 8Health News:AMN Healthcare Announces Third Quarter 2008 Results and Updates Full Year Guidance 9Health News:AMN Healthcare Announces Third Quarter 2008 Results and Updates Full Year Guidance 10Health News:AMN Healthcare Announces Third Quarter 2008 Results and Updates Full Year Guidance 11Health News:AMN Healthcare Announces Third Quarter 2008 Results and Updates Full Year Guidance 12Health News:AMN Healthcare Announces Third Quarter 2008 Results and Updates Full Year Guidance 13Health News:AMN Healthcare Announces Third Quarter 2008 Results and Updates Full Year Guidance 14Health News:AMN Healthcare Announces Third Quarter 2008 Results and Updates Full Year Guidance 15Health News:K-State and Kansas Health Foundation Team Up to Promote 'One Health Kansas' 2Health News:K-State and Kansas Health Foundation Team Up to Promote 'One Health Kansas' 3Health News:Phyhealth Issues 2008 Third Quarter Financial Statements 2
(Date:7/23/2014)... July 23, 2014 The Board of Directors ... leading provider of clinical trial imaging solutions, announced today ... named president and chief executive officer, effective immediately.  Mr. ... 2013 and has held the positions of interim president ... Dr. Charles E. Phelps , Ph.D., chairman ...
(Date:7/23/2014)... , July 23, 2014 Pharmavite LLC ... company,s chief customer officer effective immediately. Toll recently served ... sales and marketing, category management, private label and sales ... In his new global role, Toll will expand his ... sales planning. "Toll,s appointment to chief customer ...
(Date:7/23/2014)... , July 23, 2014  RT Oncology Services Corporation ... to join its board of directors. Mr. Mundie is ... where he works on strategic projects within the company ... Microsoft,s chief research and strategy officer. ... of RainTree, said, "Craig is a visionary technology executive. ...
Breaking Medicine Technology:Eric T. Converse Named President And Chief Executive Officer Of VirtualScopics, Inc. 2Eric T. Converse Named President And Chief Executive Officer Of VirtualScopics, Inc. 3Eric T. Converse Named President And Chief Executive Officer Of VirtualScopics, Inc. 4Craig Mundie Joins RainTree Oncology Board of Directors 2Craig Mundie Joins RainTree Oncology Board of Directors 3
Fome-Cuf® tubes can breathe with the patient to provide a safe, effective, and low pressure seal throughout the ventilatory cycle....
Portex® pediatric tracheostomy tubes offer a choice in both form and fit. , ,The anatomical shape of the tube shaft along with the caudal angle of the 15 mm connector provide comfort and security...
Indications For Usage: ,Bypass upper airway obstructions, provide long term ventilation, support and/or manage tracheal/bronchial secretions....
KIMBERLY-CLARK BALLARD Neonatal and Pediatric TRACH CARE Manifold features lavage/irrigation port and locking thumb port. Multiple French sizes and packaging configurations. Gamma sterilized....
Medicine Products: