Navigation Links
Sudden decline in testosterone may cause Parkinson's disease symptoms in men
Date:7/26/2013

(CHICAGO) The results of a new study by neurological researchers at Rush University Medical Center show that a sudden decrease of testosterone, the male sex hormone, may cause Parkinson's like symptoms in male mice. The findings were recently published in the Journal of Biological Chemistry.

One of the major roadblocks for discovering drugs against Parkinson's disease is the unavailability of a reliable animal model for this disease.

"While scientists use different toxins and a number of complex genetic approaches to model Parkinson's disease in mice, we have found that the sudden drop in the levels of testosterone following castration is sufficient to cause persistent Parkinson's like pathology and symptoms in male mice," said Dr. Kalipada Pahan, lead author of the study and the Floyd A. Davis endowed professor of neurology at Rush. "We found that the supplementation of testosterone in the form of 5-alpha dihydrotestosterone (DHT) pellets reverses Parkinson's pathology in male mice."

"In men, testosterone levels are intimately coupled to many disease processes," said Pahan. Typically, in healthy males, testosterone level is the maximum in the mid-30s, which then drop about one percent each year. However, testosterone levels may dip drastically due to stress or sudden turn of other life events, which may make somebody more vulnerable to Parkinson's disease.

"Therefore, preservation of testosterone in males may be an important step to become resistant to Parkinson's disease," said Pahan.

Understanding how the disease works is important to developing effective drugs that protect the brain and stop the progression of Parkinson's disease. Nitric oxide is an important molecule for our brain and the body.

"However, when nitric oxide is produced within the brain in excess by a protein called inducible nitric oxide synthase, neurons start dying," said Pahan.

"This study has become more fascinating
'/>"/>

Contact: Deb Song
deb_song@rush.edu
312-942-0588
Rush University Medical Center
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Obstructive sleep apnea raises risk of sudden cardiac death, Mayo Clinic finds
2. 2013 Alleged Zithromax Arrhythmia and Sudden Death Cases Update: Canadian Health Officials Issue Warning
3. Estrogen Levels Tied to Risk for Sudden Cardiac Death in Study
4. Zithromax Arrhythmia and Sudden Death Allegation Claims Now Being Accepted by Resource4thePeople Lawyers
5. Beaumont doctors call for training to reduce sudden cardiac arrest fatalities in schools
6. Zithromax Arrhythmia and Sudden Death Allegation Lawsuits Now Being Investigated by Resource4thePeople Lawyers
7. Sudden death in young athletes: Important causes not identified by the screening process
8. ECG screening for competitive athletes would not prevent sudden death
9. Fish oil may protect dialysis patients from sudden cardiac death
10. Miami Injury Attorneys Reacts to Toyota's Decision to Settle High-Profile Sudden Acceleration Case
11. Predicting risk of arrhythmias and sudden cardiac death: Theres a computer model for that
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/22/2014)... ARBOR, Mich. A surprising new study pulls back ... in health care: differences in payment and income between ... who don,t. , Contrary to perception, the research ... to favor surgeons and other procedure-performing doctors. , The ... simple difference in pay per minute explains why doctors ...
(Date:9/22/2014)... Amy Norton HealthDay Reporter ... may fare better when newborn intensive care units (NICU) set ... infants, a new study finds. Researchers at one children,s ... and were less distressed when their NICU switched from the ... findings, published online Sept. 22 in the journal Pediatrics ...
(Date:9/22/2014)... patients undergoing breast cancer surgery require additional operations because ... in the initial operation. However, researchers at Brigham and ... developed that will help surgeons better distinguish cancerous breast ... repeat operations. , The study is ... the Proceedings of the National Academy of Sciences ...
(Date:9/22/2014)... scientists have found that an anticonvulsant drug may help ... Although dozens of antibiotics target what bacteria do, their ... bacteria are created, and they found there is a ... important as there is growing concern worldwide about how ... The World Health Organization has declared that antibiotic resistance ...
(Date:9/22/2014)... September 22, 2014 This Flash Report ... stakeholder management needs for the Prostate Cancer market. , ... on stakeholder strategies for any launching Prostate Cancer product:, ... differentiation within an increasingly crowded market , ... impact of identifying community-based thought leaders and stakeholders ...
Breaking Medicine News(10 mins):Health News:Think the system for paying US doctors is rigged to favor surgeons? Study may surprise you 2Health News:Think the system for paying US doctors is rigged to favor surgeons? Study may surprise you 3Health News:Think the system for paying US doctors is rigged to favor surgeons? Study may surprise you 4Health News:Newborn ICUs With Private Family Rooms Benefit Preemies: Study 2Health News:Newborn ICUs With Private Family Rooms Benefit Preemies: Study 3Health News:The fine line between breast cancer and normal tissues 2Health News:Download HeartBeat Experts White Paper: Stakeholder Management for new Prostate Cancer Products 2
... protein previously thought not to exist in adult human lungs ... scientists have found, but it also has a major role ... cancers. The protein, called the calcium-sensing receptor, sits on ... known as squamous-cell carcinomas, according to new research. As ...
... new source of stem cells A team ... Institute for Biological Studies, La Jolla, has generated data in ... tissue in the smell-sensing region of the human nose (human ... cells to treat brain disorders in which nerve cells are ...
... couples is affected by wives, inability to fall asleep at ... that will be presented Monday, June 13, in Minneapolis, Minn., ... Professional Sleep Societies LLC (APSS). Results show ... predicted their reports of more negative and less positive marital ...
... studied controversial aspects of Medicare spending and quality ... from the nation,s largest health services research professional ... 2011 Article of the Year Award to Jeffrey ... for Outcomes Research at The Children,s Hospital of ...
... MONDAY, June 13 (HealthDay News) -- Breast-feeding appears to reduce ... especially when babies are exclusively breast-fed, a new study suggests. ... infants, and studies have shown breast-feeding aids babies, development and ... mothers. Now, there is more evidence that breast-feeding may reduce ...
... about the signs and symptoms of drug impairment among ... Houston State University (SHSU) June 14. The free, six-hour ... Sept. 1, 2011., The program, funded by the Texas ... including human resources personnel, owners and executive staff. The ...
Cached Medicine News:Health News:Scientists identify key component in lethal lung cancer complication 2Health News:Scientists identify key component in lethal lung cancer complication 3Health News:Scientists identify key component in lethal lung cancer complication 4Health News:JCI online early table of contents: June 13, 2011 2Health News:JCI online early table of contents: June 13, 2011 3Health News:JCI online early table of contents: June 13, 2011 4Health News:JCI online early table of contents: June 13, 2011 5Health News:JCI online early table of contents: June 13, 2011 6Health News:JCI online early table of contents: June 13, 2011 7Health News:JCI online early table of contents: June 13, 2011 8Health News:JCI online early table of contents: June 13, 2011 9Health News:JCI online early table of contents: June 13, 2011 10Health News:Study finds that wives' sleep problems have negative impact on marital interactions 2Health News:Hospital outcomes research named 'Article of the Year' 2Health News:Hospital outcomes research named 'Article of the Year' 3Health News:Breast-feeding May Shield Against Sudden Infant Death Syndrome 2Health News:Breast-feeding May Shield Against Sudden Infant Death Syndrome 3Health News:Drug recognition program available for Texas employers 2
(Date:9/22/2014)... China Nepstar Chain Drugstore Ltd. (NYSE: NPD ... China based on the number of directly ... General Meeting of Shareholders (the "AGM") on October 22, 2014 at ... meeting room of the Company at 6th Floor, Tower B, Xinnengyuan ... Guangdong Province 518054, People,s Republic of ...
(Date:9/19/2014)... , Sept. 19, 2014 Medical ... forging relationships with key opinion leaders (KOLs) who ... competition. Despite the critical nature of the MSL ... challenges, including altering the landscape for creating and ... According to research, the oversight responsibility for the ...
(Date:9/19/2014)... N.C. , Sept. 19, 2014 A ... Best Practices, LLC with three issues he wanted the ... The use of external personnel (especially for secondary research) ... in the face of increased workload , Automation ... better knowledge management , How to implement and ...
Breaking Medicine Technology:China Nepstar Chain Drugstore Schedules Annual General Meeting of Shareholders for October 22, 2014 2Role of Medical Science Liaisons Shifting in Healthcare Industry 2In Era of Competing Needs, Market Research Groups Under Pressure to Utilize Automation and External Staffing 2
... world-leading developer and marketer of innovative medical technologies for ... Bradford (Brad) Barton as President, ConvaTec U.S.   ... the ConvaTec U.S. organization across the company,s three core ... and Critical Care.   Barton joined ConvaTec ...
... SPRING, Md., Nov. 9, 2010 The U.S. Food ... undergoing computed tomography (CT) brain perfusion scans were accidently ... properly used, the CT scanners did not malfunction. Instead, ... scanners resulted in these overdoses. However, the FDA has ...
Cached Medicine Technology:Bradford Barton Named President, ConvaTec U.S. 2FDA Working to Prevent Radiation Overdoses During CT Scans 2FDA Working to Prevent Radiation Overdoses During CT Scans 3
Fixed smooth rod which slides on skin. Designated most popular model or size....
Grooved roller, on which knife oscillates....
Disposable. For use with the N4086....
30 mm button end blade. Flat handle....
Medicine Products: