Navigation Links
Successful results against human leishmaniasis with a more efficient and economic vaccine
Date:12/19/2012

A research coordinated by the UAB has succeeded in testing a vaccine against leishmaniasis. The vaccine was tested with the best animal model existing, the golden hamster, and can be produced at low costs by using insect larvae. The research, published in the latest edition of PLoS ONE, is an important step towards the fight against a disease which causes the death of 70,000 people each year in developing countries and of countless dogs, which also suffer from this disease and are its natural reservoir.

Leishmaniasis is one of the main health problems existing at global scale. It is produced by the protozoan Leishmania infantum, and canines, which can also be infected with the disease, are the main reservoirs of the organism. The disease is transmitted by insects from the Phlebotominae subfamily (sandflies), which are very similar to mosquitos. Clinical manifestations can go anywhere from minor skin sores to organ complications and, in the worst cases, death. The disease causes 70,000 deaths a year, mainly in developing countries, and affects over 12 million people around the world. Some 1.5 to 2 million new cases appear each year and an additional 350 million people are at risk of contracting the disease. Leishmaniasis is considered an endemic disease in parts of Asia, Africa, southern Europe, Mexico, Central America and South America. With the AIDS epidemic, leishmaniasis in humans has reactivated in many countries. Current treatments are unsatisfactory and, even though the most reasonable via to fight the disease would be to obtain an efficient vaccine, conventional vaccines until now have failed.

The research team led by the UAB compared the results of applying different vaccine strategies to the best animal model in which to study the human variant of the disease: the golden hamster. The results show that the most effective strategy is a combination of two vaccines created by the researchers: three doses of DNA with genes from the L. infantum and two doses of proteins coded by these genes.

The protein vaccine can be obtained at a low cost thanks to the use of insect larvae. To create the vaccine scientists isolated protozoan genes, inserted them into a virus which affects insects (baculovirus) and used these to infect larvae of a small worm, the cabbage looper (Trichoplusia ni). The larvae act as bioreactors and produce in large amounts and at a much lower cost than conventional reactors based on microorganisms the proteins which code these genes, and which are responsible for a protective response in vaccinated individuals. Using this method, a DNA vaccine can be manufactured with the protozoan protein coding genes, and a second vaccine with proteins associated with these genes (produced at a low cost using insect larvae), with the aim of increasing its effectiveness. This vaccine strategy can be used both in a preventive and a therapeutic manner, in both humans and dogs. Presently, the possibility of a translational phase is being contemplated with the aim of transferring as quickly as possible the results of this basic research to clinical practices, and of increasing the efficacy even more by using drugs to boost the immune response.


'/>"/>
Contact: Maria Jesus Delgado
MariaJesus.Delgado@uab.cat
34-935-814-049
Universitat Autonoma de Barcelona
Source:Eurekalert

Related medicine news :

1. Dr. Farshchian: Muscular Contusions are Now Being Treated Successfully at The Center for Regenerative Medicine in Miami
2. QuickMedical Announces Successful Sales and Marketing Results for 2012
3. Muscular Contusions Are Now Being Treated Successfully by Dr. Farshchian Using Cell Therapy
4. Barrow researchers successfully destroy brain tumor cells
5. Imaging facility develops successful radiation dose reduction program
6. Study IDs 4 Key Habits of Successful Aging
7. Study: Clot removal devices successful tools for acute ischemic stroke treatment
8. New drug successfully halts fibrosis in animal model of liver disease
9. Health coaches could be key to successful weight loss, study suggests
10. DermaShoppe.com Celebrates Its Second Successful Year in Online Skin Care
11. Online weight loss programs that feature successful dieters may help
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/20/2017)... ... July 20, 2017 , ... ... further expand its existing adherence automation lines. The ATP® Mini and InspectRx® ... technology of TCG’s standard products, but at a size and price point that ...
(Date:7/20/2017)... ... July 20, 2017 , ... ... since 2014, top travel insurance solution company VisitorsCoverage Inc. has launched TMQuotes, a ... major international travel insurance products online, under their own brand. The online marketplace ...
(Date:7/20/2017)... ... 2017 , ... A local summer theatre camp is celebrating ... support fine arts programs in Chester County’s Elementary Schools. In late June, students ... , More than 850 people attended the two performances, an increase from ...
(Date:7/20/2017)... (PRWEB) , ... July 19, 2017 , ... Med Tech ... the Minnesota based Health IT business unit of Constellation Inc., a move that will ... established base of operations in St. Louis, the acquisition is expected to help ...
(Date:7/20/2017)... ... July 19, 2017 , ... A July 5th ... weight loss surgery patients who had received a body contouring procedure reported experiencing a ... clinic Beverly Hills Physicians (BHP), which provides both types of procedures, notes that this ...
Breaking Medicine News(10 mins):
(Date:7/13/2017)... July 13, 2017  Centurion Medical Products, a leader in medical ... ® fecal impaction removal device for hospice patient care. ... Centurion Medical Products ... Patient pain management and emotional comfort are ... help alleviate patient pain while preventing unneeded emergency department admission due ...
(Date:7/12/2017)... Lilly and Company (NYSE: LLY ) has entered ... patent litigation in the U.S. District Court for the Eastern ... ® (tadalafil) unit dose patent. This patent was previously ... the agreement, Cialis exclusivity is now expected to end at ... dose patent for Cialis is valid and infringed by companies ...
(Date:7/11/2017)... July 11, 2017  Sysmex America, Inc., a ... testing equipment as well as middleware information systems ... to make quality assurance easier and more risk ... well known for the innovation that it delivers ... elevates quality assurance processes to a new level ...
Breaking Medicine Technology: