Navigation Links
Successful repair of bone defects using a novel tissue engineered bone graft
Date:12/4/2013

Researchers at the Department of Orthopaedics, of the Second Affiliated Hospital of Xi'an Jiaotong University Health Science Center, led by Dr. Kunzheng Wang and Dr. Pei Yang have developed a novel biomimetic tissue engineered bone graft based on rabbit adipose derived stem cells (rASCs), collagen I and a porous beta-tricalcium phosphate (β-TCP) scaffold. Furthermore, the critical-sized bone defects model of rabbits was used to evaluate the efficiency of the construct. This discovery, reported in the December 2013 issue of Experimental Biology and Medicine, provides a novel candidate for bone defect repair.

Although bone has the capacity for regenerative growth and remodeling, these processes are often impaired in clinical situations in which loss of bone is caused by disease, trauma or tumor resection. More than 800,000 patients receive bone graft operations annually around the world. With the rapid development and progress of material and manufacturing sciences, tissue engineered bone grafting has become a promising technique in bone defect treatment. Bone tissue engineering involves three key factors: the seeding cell, growth factors and a porous scaffold. In the present study, rASCs were selected as the cell source for bone tissue engineering based upon the use of autologous ASCs for minimizing immunological rejection and the fact that greater cell numbers can be harvested from the patient with less pain. Collagen I was used to enhance the efficiency of cell adhesion. For the β-TCP scaffold the authors used a pore size of 460.9078.75 μm and interconnection pore size of 157.6637.94 μm. These were found to be biocompatible, osteoconductive, and able to be degraded, which facilitate vascularization and rapid bone growth progression. The in vivo experimental results demonstrated that the novel biomimetic tissue engineered bone graft could promote osteogenesis in critically sized defects. Twelve weeks after implantation, the defects were almost completely repaired by the presence of the cortical bone and medullary cavity. The results also suggested that the degeneration of the scaffolds may be accelerated by the interaction of rASCs, collagen I and the biomaterials.

"We hope to garner new insight into the engineering of rASCs-based bone tissue for clinical application". said Dr. Kunzheng Wang, senior author and Distinguished University Professor, Vice Chairmen of the Chinese Orthopaedic Association (COA).

Dr. Steven R. Goodman, Editor-in-Chief of Experimental Biology and Medicine, said "This exciting study by Professor Wang and his colleagues has provided a novel stem cell based and tissue engineered construct which can repair damaged bone. In the future these findings could be translated into the clinical setting".


'/>"/>

Contact: Kunzheng Wang
kunzhengwang@126.com
Society for Experimental Biology and Medicine
Source:Eurekalert

Related medicine news :

1. Nationwide Title Clearing, Inc. (NTC) Continues CSR Activities With Successful “Light the Night Walk”—Event Raised Over $77,000 for Cancer Research
2. Skinspirations Responds to Local Hunger Need with Successful Charity Event, Donates Food and Funds to Metropolitan Ministries
3. The P.A.S.T. Retired Players Medical Group Concussion Treatment Program Successful For Former NFL Players
4. Almost two-thirds of women who attempt natural delivery after a c-section are successful
5. Georgetown University 50-State Report Finds More Children Have Health Coverage - Attributes Gains to Successful Federal State Partnership Programs Medicaid and CHIP
6. Dr. Peter Bassett, Dental Implants Dentist in Tempe, AZ Introduces Biomet 3i Dental Implants for Faster, More Successful Implant Procedures
7. Shared medical appointments -- Key factors for successful implementation
8. World T.E.A.M. Sports Inspires Successful Cross-Country Ride by Marine Veteran
9. Medical Answering Services Provider, AnswerNow, Successfully Integrates HIPAA-Compliant Text Messaging Services Through TigerText
10. Successfully and Naturally Manage Stress and Anxiety this Holiday Season
11. Penn docs find successful strategy to expand patient participation in hard-to-enroll clinical trials
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/22/2017)... ... February 22, 2017 , ... Becker’s ... spine practices, is featuring Michigan neurosurgeon Jay Jagannathan, M.D., as a “Spine Surgeon ... small number of neurosurgeons in Michigan performing minimally invasive back surgery that often ...
(Date:2/22/2017)... ... February 22, 2017 , ... A product of digesting ... to derive a heart-protective benefit from eating soy foods, while others do not, a ... who are able to produce equol—a substance made by some types of “good” gut ...
(Date:2/22/2017)... ... 22, 2017 , ... Forty-five percent of American respondents feel ... members or friends have also commented about their poor hearing. However, only 13 ... One reason, suggested by 89 percent of American respondents, is that they don’t ...
(Date:2/22/2017)... ... , ... Super-Sod will attend the Athens Home Show with a brand new ... from Super-Sod’s simple Athens Home Show booth of 2016, this year’s exhibit space includes ... Chris Roquemore constructed furniture from recycled pallet wood at the Super-Sod farm in Fort ...
(Date:2/22/2017)... Troy, NY (PRWEB) , ... February 22, 2017 , ... ... effort — especially for hospitals and health systems. Smith & Jones’ delves into this ... In this episode, President of Smith & Jones David Vener meets up with social ...
Breaking Medicine News(10 mins):
(Date:2/22/2017)... According to a new market research report "Process ... and Services (Analyzers, Probes & Sensors), End - User (Pharmaceutical Manufacturers, CRO ... market is poised to reach USD 3.30 Billion by 2021 from USD ... 2021. Continue Reading ... ...
(Date:2/22/2017)... -- Des scanners sur smartphone destinés aux professionnels de la ... , au Moyen-Orient et en Afrique  ... Clarius Mobile Health , une société de santé numérique dont ... Canada , a annoncé aujourd,hui qu,elle a reçu la certification ... C3 et L7, destinés à être utilisés par des professionnels de la ...
(Date:2/21/2017)... , Feb. 21, 2017 ... specialized versions are used to monitor physiological signs. These ... remote patient monitors. Remote patient monitoring is one of ... patient monitoring equipment in the market. Hence, vendors are ... smartphones and applications, which can send test results on ...
Breaking Medicine Technology: