Navigation Links
Subtyping breast cancer by immunohistochemistry to investigate survival terms
Date:5/25/2010

A study by Paul Pharoah and colleagues published in this week's PLoS Medicine evaluates immunohistochemistry-based subtype classification of breast tumors for the prediction of disease outcome. Their analysis is based on more than 10,000 breast cancer cases with early disease, and examines the influence of a patient's tumour type on the prediction of future survival.

As has been shown previously the three subtypes of ER negative disease have a poorer outcome than the ER positive disease subtypes in the short term. However, this study has shown that in the long term, the ER negative disease subtypes have a better prognosis. This study has also conclusively demonstrated that the so-called triple negative tumours (ER-, PR- and HER2-) can be divided into two sub-types (basal and non-basal) with the basal subtype having a poorer prognosis.

The observed survival patterns were independent of any systemic adjuvant therapy, suggesting that tumour biology and molecular heterogeneity within breast cancer subtypes, rather than the choice of therapy, determined the survival trends. The authors recommend that this prognostic method should be incorporated into clinical practice.

A related Perspective by Stefan Ambs in the same issue examines the clinical significance of this large study and discusses the limitations of subtype classification for prognostication and targeted therapy in the management of breast cancer.


'/>"/>

Contact: Andrew Hyde
press@plos.org
44-122-346-3330
Public Library of Science
Source:Eurekalert

Page: 1

Related medicine news :

1. Breast Cancer Study Offers New Hope
2. Dr. Phillip Chang Introduces New Ways to Decrease Scars and Potential Complications For Breast Augmentations in Loudoun and Fairfax Virginia
3. Prenatal exposure to endocrine-disrupting chemicals linked to breast cancer
4. Radiation Not Needed in Many Older Breast Cancer Patients
5. Estrogen-lowering drugs minimize surgery in breast cancer patients
6. Plastic Surgeons, Breast Surgeons Urge Team Approach to Breast Cancer Care
7. New Clues to Treating an Aggressive Breast Cancer
8. Study identifies 1 of the mechanisms behind breast cancer metastasis
9. Small Changes in Two Genes May Trigger Breast Cancer
10. Is Fear of Being Caught Naked an Obstacle to Increasing Breastfeeding Rates?
11. Researchers discover new way to rescue treatment sensitivity of breast cancer cells
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/30/2015)... (PRWEB) , ... July 30, 2015 , ... ... Program and fourth annual Institute Scholar Program. In partnership with Patient Experience Institute, ... patient experience, develop leaders on the front lines and throughout the experience movement, ...
(Date:7/30/2015)... ... July 30, 2015 , ... Zejax is a ... That Increases Training Capability , World renown body weight trainer, Paul Ziachik, ... ), that dramatically increases a person’s training capability. , The American College of ...
(Date:7/30/2015)... ... ... Using the latest online digital technologies, happiness expert Kay Walker is on a ... major depression. , “Suicide is 100% preventable. The problem is the medical community is ... needlessly everyday,” says Walker. “I’m out to end suicide. Some may say that’s unreasonable. ...
(Date:7/30/2015)... ... July 30, 2015 , ... On July 23rd ... in taxpayer money to fund the state’s large prison system, which has amassed largely ... highest rates of incarceration. In light of President Obama’s recent reduction of non violent ...
(Date:7/30/2015)... ... ... Ocean Hills Recovery has officially been accredited by CARF International, receiving some ... CARF found no areas in the OHR program that needed improvement, as they were ... receive. In addition, Ocean Hills was granted the maximum certification period of 3 years, ...
Breaking Medicine News(10 mins):Health News:The Beryl Institute Opens Applications for 2015 Patient Experience Grant and Scholar Programs 2Health News:The Beryl Institute Opens Applications for 2015 Patient Experience Grant and Scholar Programs 3Health News:Zejax is a Revolutionary New Way of BodyWeight Training Without Weights 2Health News:Happiness Expert Develops Pioneering Online Tools for Sufferers of Major Depression, and Who may be Suicidal 2Health News:Happiness Expert Develops Pioneering Online Tools for Sufferers of Major Depression, and Who may be Suicidal 3Health News:Florida Questions Its Spending on Punitive Incarceration in Light of Exorbitant Costs for Non Violent Offenders 2Health News:Florida Questions Its Spending on Punitive Incarceration in Light of Exorbitant Costs for Non Violent Offenders 3Health News:Ocean Hills Recovery Receives Accreditation from CARF International 2
... by the American Academy of Actuaries: , , What: The ... of Actuaries will ... lth care reform ... reform issues that are most important when evaluating a proposal,s prospects for leading to ...
... As the American Medical Association (AMA) works for health ... health coverage, new policy states that the AMA "support health ... pluralism, freedom of choice, freedom of practice, and universal access ... ) , , "The AMA is ...
... to earlier, more effective treatment: researchers , WEDNESDAY, June ... way to detect muscular dystrophy in the womb or ... the disease before symptoms develop. , Focusing on key ... and delays of skeletal-muscle formation in the embryos of ...
... distant nursing home patients with Parkinson,s disease access to neurologists ... study of the project the results of which were ... and Movement Disorders in Paris demonstrates that the system ... patients. "This study shows that we can ...
... ... at Falcon Field, it was jointly announced today by Air Force Director of Athletics Dr. Hans ... ... FieldTurf at Falcon Field, it was jointly announced today by Air Force Director of Athletics ...
... (Nasdaq: KNDL ), a leading, global full-service ... executives will present on important industry issues at the ... 2009, in San Diego, Calif. Kendle experts will address ... portfolio management, pregnancy registries and risk management, and patient ...
Cached Medicine News:Health News:Actuaries Provide Capitol Hill Briefing to Explore Health Care Reform Components 2Health News:AMA Supports Health System Reform Alternatives Consistent With Principles of Pluralism, Freedom of Choice, Freedom of Practice and Universal Access for Patients 2Health News:Clues to Muscular Dystrophy Seen in Womb 2Health News:Telemedicine expands reach of care for Parkinson's patients 2Health News:Telemedicine expands reach of care for Parkinson's patients 3Health News:Air Force to Install Fieldturf at Falcon Field 2Health News:Air Force to Install Fieldturf at Falcon Field 3Health News:Kendle to Share Insights at Drug Information Association 45th Annual Meeting 2Health News:Kendle to Share Insights at Drug Information Association 45th Annual Meeting 3
(Date:7/30/2015)... Takeda Pharmaceutical Company Limited ("Takeda") today announced ... post-marketing commitment and submissions of data to regulatory ... Cancer Risk Characterization Study , a large (n= ... four European countries, for pioglitazone containing medicines, including ... of follow-up. Findings demonstrate that there is no ...
(Date:7/30/2015)... 2015  Big Cloud Analytics, Inc. (BCA), a ... it is working with Intel Corporation to showcase ... Lockheed Martin Healthcare Technology Alliance. The recently formed ... providers, medical technology companies and academic institutions. Its ... improve care in rapidly evolving and growing areas ...
(Date:7/30/2015)... , July 30, 2015  Cleave Biosciences ... Trademark Office has granted the company a key ... Cleave,s lead molecule CB-5083. This newly ... inhibitors of p97," U.S. 9,062,026, allows for claims ... first-in-class, highly selective oral inhibitor of p97, a ...
Breaking Medicine Technology:Takeda Announces Completion of the Pioglitazone Post-Marketing Commitment and Submission of Results to the EMA, the FDA and the PMDA 2Takeda Announces Completion of the Pioglitazone Post-Marketing Commitment and Submission of Results to the EMA, the FDA and the PMDA 3Takeda Announces Completion of the Pioglitazone Post-Marketing Commitment and Submission of Results to the EMA, the FDA and the PMDA 4Takeda Announces Completion of the Pioglitazone Post-Marketing Commitment and Submission of Results to the EMA, the FDA and the PMDA 5Takeda Announces Completion of the Pioglitazone Post-Marketing Commitment and Submission of Results to the EMA, the FDA and the PMDA 6Big Cloud Analytics Develop Internet of Things (IoT) Solutions with Intel Supporting Launch of Lockheed Martin Healthcare Technology Alliance 2Big Cloud Analytics Develop Internet of Things (IoT) Solutions with Intel Supporting Launch of Lockheed Martin Healthcare Technology Alliance 3
... Sept. 29 MedPro Imaging, a premier provider of ... Ultrasound Transducer Repair Division.  Based on proprietary repair technology ... will offer high quality computer-based transducer repair services designed ... probe exchange programs. "The industry has been ...
... Crosstex International, a subsidiary of Cantel Medical Corp. ... of sponsored research that suggests a far greater infection ... as surgical masks, than previously understood. The key outcome ... is most effective when worn by a person attempting ...
Cached Medicine Technology:MedPro Imaging Launches Ultrasound Transducer Repair Division 2New Mask Study Supports CDC's Updated Guidance for Seasonal Flu Prevention Strategies 2New Mask Study Supports CDC's Updated Guidance for Seasonal Flu Prevention Strategies 3
Straight shafts with 1 x 2 teeth. Flat handle with haoles and polished finish. Delicate teeth. Most popular size or model....
Straight shafts with 0.12 mm teeth and 5 mm tying platform. Serrated handle with polished finish. Manufactured in titanium....
Straight shafts with polished finish. Teeth: 0.12 mm. Tying platform: 5.0 mm. Wide Serrated....
Straight shafts with 1 x 2 teeth and 5 mm tying platform. Serrated handle with dull finish....
Medicine Products: