Navigation Links
Substance in Red Grapes and Wine Key to Alzheimer's Disease
Date:11/16/2008

Scientists at The Feinstein Institute for Medical Research have figured out why a substance in red grapes and red wine lowers amyloid beta levels that accumulate in the brains of Alzheimer’s patients.

Washington, DC (Vocus) November 16, 2008 -- Scientists at The Feinstein Institute for Medical Research have figured out why a substance in red grapes and red wine lowers amyloid beta levels that accumulate in the brains of Alzheimer’s patients. Medicines targeting amyloid beta that make up the clumps in the hallmark plaques are now in many phases of experimental testing. The hope is that clearing out amyloid beta before it accumulates could stave off the disease and reduce symptoms. Scientists at the Feinstein hope to develop this natural substance, called resveratrol, or synthetic versions, for the treatment of Alzheimer’s.

Valorie Vingtdeux, PhD and their colleagues have discovered that a specific kinase – AMPK – controls Abeta levels. AMPK is an interesting protein because it is a metabolic sensor in the cells and throughout the body. It senses levels of ATP, the body’s fuel source. When ATP levels drop, AMPK is activated to prepare the cells to adjust to the metabolic change in the body – when fuel is low. It’s like a driver moving along at 50 and slowing down when it realizes that there is trouble ahead.

Resveratrol activates AMPK and in turn this protein lowers Abeta levels. Dr. Vingtdeux presented these findings at the Society for Neuroscience annual meeting in Washington, DC, this week. The work has been done so far in cell culture but Philippe Marambaud, PhD, who oversees the research, said there is every reason to believe that a similar process takes place in nature. “We hope that this result will translate into beneficial effects for Alzheimer’s patients someday,” said Dr. Marambaud. This is an important finding because the scientists identified a new potential molecular target – AMPK – to lower Abeta levels in Alzheimer’s. It also opens the door to considering more potent analogs of resveratrol. Feinstein scientists are now screening libraries of substances to see whether there are any compounds that could mimic the effects found in this substance. As it is, the amounts found in grapes and wine are small and it would not be feasible to ingest enough to have a benefit. The Feinstein chemists have identified several compounds that are now in different stages of testing.

Dt. Marambaud said that there are drugs available that are used for type 2 diabetes, metabolic syndrome and obesity that activate AMPK.

###

Read the full story at http://www.prweb.com/releases/Feinstein_Institute/Alzheimers_red_wine/prweb1617724.htm


'/>"/>
Source: PRWeb
Copyright©2008 Vocus, Inc.
All rights reserved  

Related medicine news :

1. Substance tackles skin cancer from 2 sides
2. Sobriety Rocks: Celebrity Rehab Staff Joins Bianca Center for Substance Abuse
3. Adolescent insomnia linked to depression and substance abuse during adolescence and young adulthood
4. E-prescribing of Controlled Substances Moves Real-Time Prescription Drug Monitoring Toward Reality
5. California Drug Rehab Program Launches New Life Skills Classes to Young Adults as Substance Abuse Treatment
6. Bipolar Teens at Greater Risk of Substance Abuse
7. Report confirms increased risk of smoking, substance abuse in bipolar adolescents
8. Homeless youth need more than treatment for substance abuse, study says
9. San Diego State University Controlled Substance Investigation
10. Fetal Exposure to Substance Abuse Changes Brain Structure
11. Dads Substance Use Hurts Expectant Moms Efforts to Quit
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Substance in Red Grapes and Wine Key to Alzheimer's Disease
(Date:6/23/2017)... ... ... Ross Insurance Agency ( http://www.rossinsuranceagency.com ) saves clients thousands ... recent update of flood zones, more people than ever are in flood zone ... reflect the actual risk in flood zone areas during a time when FEMA ...
(Date:6/23/2017)... ... , ... All-Star Insurance, a family managed agency that offers insurance management assistance ... the launch of a new charity drive to benefit women in the area diagnosed ... that an estimated 252, 710 new cases of invasive or high risk breast cancer ...
(Date:6/22/2017)... ... June 22, 2017 , ... United Benefit ... welcome Whipple & Company as its newest Partner Firm. Headquartered in Coconut Creek, ... clients’ risk while tailoring optimized benefit packages that strengthen the relationship between employer ...
(Date:6/22/2017)... Winona, MN (PRWEB) , ... June 22, 2017 ... ... around the world, announced today that it has received certification for ANSI/ASIS PSC.1-2012. ... East often occurs in environments where the rule of law has been degraded. ...
(Date:6/20/2017)... ... June 20, 2017 , ... United ... of its annual “UBBIE” Awards (pronounced you-bee) for 2017. The award honors ... toward their involvement with UBA, the clients they serve, and the benefits insurance ...
Breaking Medicine News(10 mins):
(Date:6/19/2017)... June 19, 2017  Researchers from DRUGSCAN ® ... will host a live, complimentary webinar titled, "Untangling methods ... to the real world" on Wednesday June 28, 2017 ... This webinar will feature interviews with recreational and ... the manipulation techniques abusers use to prepare opioid tablets ...
(Date:6/16/2017)... years ago today, the Monterey Pop Festival opened its gates ... Francisco "Summer of Love."  To celebrate the anniversary, Northern Light® ... market research portals that it will begin delivering to customers ... "Summer of Love (For Our Customers)."  ... Northern Light ...
(Date:6/14/2017)... The Bio Supply Management Alliance (BSMA) has ... and the Biomedical Manufacturing Network to advance ... California by providing a platform for ... workforce development. The primary focus of this alliance is ... well as small and mid-sized biomedical companies. ...
Breaking Medicine Technology: