Navigation Links
Substance in Red Grapes and Wine Key to Alzheimer's Disease
Date:11/16/2008

Scientists at The Feinstein Institute for Medical Research have figured out why a substance in red grapes and red wine lowers amyloid beta levels that accumulate in the brains of Alzheimer’s patients.

Washington, DC (Vocus) November 16, 2008 -- Scientists at The Feinstein Institute for Medical Research have figured out why a substance in red grapes and red wine lowers amyloid beta levels that accumulate in the brains of Alzheimer’s patients. Medicines targeting amyloid beta that make up the clumps in the hallmark plaques are now in many phases of experimental testing. The hope is that clearing out amyloid beta before it accumulates could stave off the disease and reduce symptoms. Scientists at the Feinstein hope to develop this natural substance, called resveratrol, or synthetic versions, for the treatment of Alzheimer’s.

Valorie Vingtdeux, PhD and their colleagues have discovered that a specific kinase – AMPK – controls Abeta levels. AMPK is an interesting protein because it is a metabolic sensor in the cells and throughout the body. It senses levels of ATP, the body’s fuel source. When ATP levels drop, AMPK is activated to prepare the cells to adjust to the metabolic change in the body – when fuel is low. It’s like a driver moving along at 50 and slowing down when it realizes that there is trouble ahead.

Resveratrol activates AMPK and in turn this protein lowers Abeta levels. Dr. Vingtdeux presented these findings at the Society for Neuroscience annual meeting in Washington, DC, this week. The work has been done so far in cell culture but Philippe Marambaud, PhD, who oversees the research, said there is every reason to believe that a similar process takes place in nature. “We hope that this result will translate into beneficial effects for Alzheimer’s patients someday,” said Dr. Marambaud. This is an important finding because the scientists identified a new potential molecular target – AMPK – to lower Abeta levels in Alzheimer’s. It also opens the door to considering more potent analogs of resveratrol. Feinstein scientists are now screening libraries of substances to see whether there are any compounds that could mimic the effects found in this substance. As it is, the amounts found in grapes and wine are small and it would not be feasible to ingest enough to have a benefit. The Feinstein chemists have identified several compounds that are now in different stages of testing.

Dt. Marambaud said that there are drugs available that are used for type 2 diabetes, metabolic syndrome and obesity that activate AMPK.

###

Read the full story at http://www.prweb.com/releases/Feinstein_Institute/Alzheimers_red_wine/prweb1617724.htm


'/>"/>
Source: PRWeb
Copyright©2008 Vocus, Inc.
All rights reserved  

Related medicine news :

1. Substance tackles skin cancer from 2 sides
2. Sobriety Rocks: Celebrity Rehab Staff Joins Bianca Center for Substance Abuse
3. Adolescent insomnia linked to depression and substance abuse during adolescence and young adulthood
4. E-prescribing of Controlled Substances Moves Real-Time Prescription Drug Monitoring Toward Reality
5. California Drug Rehab Program Launches New Life Skills Classes to Young Adults as Substance Abuse Treatment
6. Bipolar Teens at Greater Risk of Substance Abuse
7. Report confirms increased risk of smoking, substance abuse in bipolar adolescents
8. Homeless youth need more than treatment for substance abuse, study says
9. San Diego State University Controlled Substance Investigation
10. Fetal Exposure to Substance Abuse Changes Brain Structure
11. Dads Substance Use Hurts Expectant Moms Efforts to Quit
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Substance in Red Grapes and Wine Key to Alzheimer's Disease
(Date:3/23/2017)... (PRWEB) , ... March 23, 2017 , ... ... investment in Los Angeles based healthcare technology company California Healthcom Group (CHG). ... the US, and healthcare arena. With headquarters in California, CHG is a growing, ...
(Date:3/23/2017)... Scottsdale, AZ (PRWEB) , ... March 23, 2017 , ... ... helping people around the world to manage stress and anxiety. , “Buzzies change ... Serin, neuropsychologist, inventor and co-founder of Buzzies. , Since its launch date in December ...
(Date:3/23/2017)... ... March 23, 2017 , ... ... new solution that enables organizations to easily reprint customer invoices, bills, statements and ... automates all of the steps needed to retrieve and print the documents and ...
(Date:3/23/2017)... CA (PRWEB) , ... March 23, 2017 , ... ... management and workflow solutions, today named The Resource Group as their 2016 Microsoft ... and partner conference in Newport Beach, CA. The award recognizes The Resource ...
(Date:3/23/2017)... ... 2017 , ... ChenMed, a privately owned medical, management and ... executive team expansion needed to further optimize growth and performance. , “We are ... Chen, MD, ChenMed Chief Executive Officer. “George Wheeler and Donald Trexler round-out ...
Breaking Medicine News(10 mins):
(Date:3/23/2017)... 23, 2017 Summary ... disease pipeline guide Primary Hyperoxaluria - Pipeline Review, ... Hyperoxaluria (Genito Urinary System And Sex Hormones) pipeline ... characterized by recurrent kidney and bladder stones. It ... oxalate. Symptoms include blood in the urine, pain ...
(Date:3/23/2017)... , March 23, 2017  Digital Pharmacist ... ), a rapidly growing digital health company, ... mobile app that allows patients to manage their ... locations such as Denver Health Pharmacy, USave Pharmacy ... acquisition helps Digital Pharmacist accelerate its product development ...
(Date:3/23/2017)...  Ethicon* today announced the completion of its ... medical device company that manufactures and markets the ... of Gastroesophageal Reflux Disease (GERD). This acquisition is ... of minimally invasive options for patients suffering from ... the transaction have not been disclosed. ...
Breaking Medicine Technology: