Navigation Links
Studying marrow, URMC researchers accelerate blood stem cells
Date:12/5/2012

University of Rochester Medical Center scientists are testing a new approach to speed a patient's recovery of blood counts during a vulnerable period after a stem-cell transplant, according to a study published in the journal Stem Cells.

Laura M. Calvi, M.D., and Rebecca L. Porter, an M.D./Ph.D. student in Calvi's lab, reported that prostaglandin E2 (PGE2), a drug previously used to treat stomach ulcers, boosts blood production following an assault on the bone marrow from radiation or chemotherapy. Although their study was done in mice, Calvi believes it has significance for patients in the future.

"Our research suggests exciting potential to remedy myelosuppression," said Calvi, an associate professor of Medicine at URMC, with a special interest in endocrine/metabolism and the way blood stem cells behave. "During the first six weeks or so after a transplant, patients can easily acquire serious infections due to low blood counts. It's during this window that we're investigating new opportunities for replenishing cells in the bone marrow, and understanding the mechanisms by which this occurs."

Stem cell transplants, also known as bone marrow transplants or peripheral blood transplants, can be life-saving therapies for people with leukemia, other blood cancers, or blood disorders. The James P. Wilmot Cancer Center at URMC performs about 120 transplants a year, making it the largest program in western New York.

Blood stem cells mostly live in the bone marrow (spongy center of bones) where they divide or stay quiet, mature, and then enter the blood stream, or die. Many things influence the behavioral choices of these cells. And when leukemia, certain types of lymphoma, or injury from chemo and radiation destroys blood stem cells, a transplant offers a fresh replacement.

However, wiping out blood cells (healthy cells and cancer) during the transplant process also presents grave risks for the patient. Transplant success is partly determi
'/>"/>

Contact: Leslie Orr
Leslie_Orr@urmc.rochester.edu
University of Rochester Medical Center
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Does Studying for Law School Test Boost Your Brain?
2. By studying animal health, researchers find improved ways for developing, testing cancer therapies
3. Studying couples to improve health, better relationships
4. UNM Cancer Center researchers study new target for breast cancer
5. Barrow researchers successfully destroy brain tumor cells
6. Western University researchers make breakthrough in arthritis research
7. Researchers report first success of targeted therapy in most common non-small cell lung cancer
8. USC, Oxford researchers find high fructose corn syrup-global prevalence of diabetes link
9. Researchers study cry acoustics to determine risk for autism
10. Researchers explore social media as preventative method for infectious diseases
11. New mechanism for cancer progression discovered by UNC and Harvard researchers
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/21/2014)... August 22, 2014 Top10BestSEOHosting.com has ... announces that iPage ( http://www.top10bestseohosting.com/go/iPage/ ) is one ... 2014. , The manager of Top10BestSEOHosting.com states, ... hosting supplier. Actually, these companies have outperformed their ... customer support. People can get the best web ...
(Date:8/21/2014)... Living in a quality residential community ... along with it. A quality Home Owners Association like ... are available. , Simpson Mill Plantation, ... Community Association Management, LLC made a recent investment in ... provide an additional amenity for their neighborhood. , Situated ...
(Date:8/21/2014)... coronary arteries of chronic kidney disease patients may be ... a new study in the Journal of the ... at the Johns Hopkins Bloomberg School of Public Health ... measures of subclinical atherosclerosis in predicting the risk of ... 50 percent of all patients with chronic kidney disease ...
(Date:8/21/2014)... 21, 2014 Improv performers from Fun ... with dementia at Silverado Turtle Creek memory care community ... of entertainers ranging from ages 10 to 16, delivers ... their 40-minute set. The troupe's philosophy is that improv ... allows them to touch audiences regardless of their circumstance ...
(Date:8/21/2014)... The City of Garden Grove is pleased ... for its inaugural “Re:Imagine Garden Grove – A Downtown ... 11 a.m. to 4 p.m., 2.85-miles of Garden Grove ... downtown will be filled with diverse music, dance, interactive ... (CARS), for all to enjoy. , The car-free route ...
Breaking Medicine News(10 mins):Health News:iPage Reviews Unveiled Online At Top10BestSEOHosting.com 2Health News:Recreation is the Heart of the Community at Simpson Mill Plantation; Chooses American Parks Company™ for New Playground Equipment 2Health News:Recreation is the Heart of the Community at Simpson Mill Plantation; Chooses American Parks Company™ for New Playground Equipment 3Health News:Measuring calcium buildup to predict heart disease in those with chronic kidney disease 2Health News:Unicorn Clearance Improv Troupe Brings Laughter to Residents with Dementia at Silverado Memory Care 2Health News:"Re:Imagine Garden Grove - A Downtown Open Streets Event" 2Health News:"Re:Imagine Garden Grove - A Downtown Open Streets Event" 3Health News:"Re:Imagine Garden Grove - A Downtown Open Streets Event" 4
... ROCHESTER, Minn -- A new study led by Mayo Clinic ... a 41 percent reduction in colectomy after a year when ... October 2009 issue of Gastroenterology . Ulcerative colitis, ... the colon, is characterized by abdominal pain and diarrhea. Like ...
... Speaker Nancy Pelosi, Chairman John Dingell, and Congressman Martin ... conference this afternoon in the Capitol to discuss the benefits of ... reform legislation to senior citizens. Below are the Speaker,s ... Remarks: , "Good afternoon. Thank you all for being ...
... eleven public health and consumer advocacy organizations filed a ... court to reject a lawsuit by R.J. Reynolds, Lorillard ... provisions of the new federal law regulating tobacco products. ... industry,s challenge of a provision that requires FDA approval ...
... Time , With Rory Jaffe, MD, MBA ... J. Neuberger, Foley & Lardner LLP , MINNEAPOLIS, Sept. ... across the globe are grappling with possible wide-spread employee absenteeism ... the arrival of the H1N1 flu outbreak. To help organizations ...
... The Simmons firm, a leading national law firm in the ... second Miles for Meso 5K run/walk on Sunday, October 11, ... at www.milesformeso.org . , The Simmons ... 26 in Alton, Ill. Nearly 500 runners and walkers registered, ...
... Americans have cut back on medical care, survey finds , ... problems, 36 percent of Americans have cut back on doctor ... types of health visits they were reducing, 63 percent of ... percent said primary care physician visits and 52 percent said ...
Cached Medicine News:Health News:Ulcerative colitis treatment reduces need for surgery by almost half 2Health News:Pelosi: Health Reform Will Provide Seniors Better Benefits, Guaranteed Access to Doctors, Extended Stability for Medicare 2Health News:Pelosi: Health Reform Will Provide Seniors Better Benefits, Guaranteed Access to Doctors, Extended Stability for Medicare 3Health News:Eleven Health & Consumer Groups Urge Federal Court to Reject Tobacco Companies' Lawsuit Against FDA Tobacco Regulation Law 2Health News:Society of Corporate Compliance and Ethics to host What Compliance Professionals Need to Know about H1N1 Web Conference 2Health News:Society of Corporate Compliance and Ethics to host What Compliance Professionals Need to Know about H1N1 Web Conference 3Health News:Simmons Law Firm Presents Second 'Miles for Meso' Walk/Run Fundraiser for Mesothelioma Research 2Health News:Doctor Visits Are Getting Short Shrift in Tight Economy 2
(Date:8/21/2014)... Aug. 21, 2014 /PRNewswire-iReach/ -- ScriptPro has been ... under its Common Security Framework (CSF). According to ... Privacy Manager, "We appreciate this rigorous, top-to-bottom audit. ... that this certification signifies. Our business partners need ... THE CSF CERTIFICATION PROCESS: ScriptPro,s internal security processes ...
(Date:8/21/2014)... MELVILLE, N.Y. , Aug. 21, 2014  Henry Schein, ... of health care products and services to office-based dental, animal ... present at two investor conferences in September: , ... New York , NY at 12:50 p.m. ET ... Healthcare Conference in New York , NY at ...
(Date:8/21/2014)... -- The board of directors of VirtualScopics, Inc. (NASDAQ: ... imaging solutions, today announced that James Groff , ... Mr. Groff has held the role of acting chief ... January 2006 as an accounting manager and was promoted ... board of VirtualScopics asked Jim to assume the role ...
Breaking Medicine Technology:ScriptPro Achieves HITRUST Certification 2Henry Schein To Present At Two Investor Conferences In September 2VirtualScopics, Inc. Names James Groff Chief Financial Officer 2VirtualScopics, Inc. Names James Groff Chief Financial Officer 3VirtualScopics, Inc. Names James Groff Chief Financial Officer 4
... 25, 2011 /PRNewswire-Asia/ -- Simcere Pharmaceutical Group ("Simcere" or ... pharmaceutical company specializing in the development, manufacturing, and marketing ... announced that it has received the new drug approval ... Iremod. Iremod, which was independently developed by ...
... JUPITER, Fla., Aug. 25, 2011 BioRestorative Therapies, ... has entered into a Tangible Property License Agreement with ... enables BioRestorative Therapies to obtain adipose (fat) tissue that ... commercialize its ThermoStem Program , which is an ...
Cached Medicine Technology:Simcere's Iremod Receives SFDA New Drug Approval 2BioRestorative Therapies Signs License Agreement With University of Utah to Obtain Adipose (Fat) Tissue for its ThermoStem Program to Treat Obesity and Metabolic Disorders 2
... HandPort Systems non-adhesive sealing method ... Laparoscopic Surgrery (HALS) procedures, allowing ... and palpate throughout. Because HALS ... 6 cm, patients experience less ...
... offers a range of standard, enhanced ... delivers therapy to meet the needs ... in commercial and clinical effectiveness and ... the SleepStyle 200 series is the ...
The SleepStyle 600 series with ThermoSmart delivers humidification with anti-rainout benefits. ThermoSmart technology offers a heated breathing tube that allows the constant delivery of optimal level...
The S7 Elite is the premium device in ResMeds award-winning S7 series. All S7 devices include an option of integrated humidification....
Medicine Products: