Navigation Links
Studying marrow, URMC researchers accelerate blood stem cells
Date:12/5/2012

University of Rochester Medical Center scientists are testing a new approach to speed a patient's recovery of blood counts during a vulnerable period after a stem-cell transplant, according to a study published in the journal Stem Cells.

Laura M. Calvi, M.D., and Rebecca L. Porter, an M.D./Ph.D. student in Calvi's lab, reported that prostaglandin E2 (PGE2), a drug previously used to treat stomach ulcers, boosts blood production following an assault on the bone marrow from radiation or chemotherapy. Although their study was done in mice, Calvi believes it has significance for patients in the future.

"Our research suggests exciting potential to remedy myelosuppression," said Calvi, an associate professor of Medicine at URMC, with a special interest in endocrine/metabolism and the way blood stem cells behave. "During the first six weeks or so after a transplant, patients can easily acquire serious infections due to low blood counts. It's during this window that we're investigating new opportunities for replenishing cells in the bone marrow, and understanding the mechanisms by which this occurs."

Stem cell transplants, also known as bone marrow transplants or peripheral blood transplants, can be life-saving therapies for people with leukemia, other blood cancers, or blood disorders. The James P. Wilmot Cancer Center at URMC performs about 120 transplants a year, making it the largest program in western New York.

Blood stem cells mostly live in the bone marrow (spongy center of bones) where they divide or stay quiet, mature, and then enter the blood stream, or die. Many things influence the behavioral choices of these cells. And when leukemia, certain types of lymphoma, or injury from chemo and radiation destroys blood stem cells, a transplant offers a fresh replacement.

However, wiping out blood cells (healthy cells and cancer) during the transplant process also presents grave risks for the patient. Transplant success is partly determined by whether the body can remake adequate numbers of new hematopoietic stem cells by spurring them from their usual, quiet state.

Calvi's research discovered that early treatment with PGE2 not only accelerated blood cell recovery, but protected the surrounding microenvironment to stimulate production of the newly transplanted cells. In fact, one of the most promising aspects of the research was the observed activity in the marrow microenvironment, she said.

Prostaglandin is a hormone normally produced in the body, and during radiation or chemotherapy the hormone rushes in to mediate the inflammatory response. Prostaglandin usually remains elevated for about six days. During this time, the bone marrow begins to recover slowly on its own. However, Calvi's research also showed that feeding the PGE2 drug compound to mice seemed to offer an additional benefit during this time, by changing the marrow's environment to make it more supportive of faster and better blood cell production.

In fact, early treatment with PGE2 expanded blood cells in several different ways: Not only did the drug increase proliferation of new, healthy blood cells, but it slowed the death of cells being rapidly killed off during the response to radiation injury.

"Having the ability to manipulate the function of hematopoietic stem cells in this context offers new and meaningful approaches for the clinic," Calvi said. "Patients face very serious consequences when the bone marrow doesn't make enough platelets and other blood cells, and few options are currently available to aid the recovery."
'/>"/>

Contact: Leslie Orr
Leslie_Orr@urmc.rochester.edu
University of Rochester Medical Center
Source:Eurekalert

Related medicine news :

1. Does Studying for Law School Test Boost Your Brain?
2. By studying animal health, researchers find improved ways for developing, testing cancer therapies
3. Studying couples to improve health, better relationships
4. UNM Cancer Center researchers study new target for breast cancer
5. Barrow researchers successfully destroy brain tumor cells
6. Western University researchers make breakthrough in arthritis research
7. Researchers report first success of targeted therapy in most common non-small cell lung cancer
8. USC, Oxford researchers find high fructose corn syrup-global prevalence of diabetes link
9. Researchers study cry acoustics to determine risk for autism
10. Researchers explore social media as preventative method for infectious diseases
11. New mechanism for cancer progression discovered by UNC and Harvard researchers
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... ... ... Ellevate Network, the leading network for professional women, brought together some of ... their inaugural Summit in New York City in June. The event was livestreamed with ... 3 million. To watch the Mobilize Women video, click here . , ...
(Date:10/13/2017)... ... October 13, 2017 , ... ... Software Development, has been awarded a contract by the Center for Medicare and ... aims to accelerate the enterprise use of Agile methodologies in a consistent and ...
(Date:10/12/2017)... CA (PRWEB) , ... October 12, 2017 , ... ... Cheng, are now treating sleep apnea using cutting-edge Oventus O2Vent technology. ... a serious sleep disorder characterized by frequent cessation in breathing. Oral appliances can ...
(Date:10/12/2017)... ... ... The American College of Medical Informatics (ACMI) will present the 2017 Morris F. ... AMIA’s Annual Symposium in Washington, D.C. AMIA’s Annual Symposium is taking place ... the field of medical informatics, this prestigious award is presented to an individual whose ...
(Date:10/12/2017)... ... October 12, 2017 , ... HMP , a leader in healthcare events ... Magazine Eddie Digital Award for ‘Best B-to-B Healthcare Website.’ Winners were announced during the ... The annual award competition recognizes editorial and design excellence across a range of sectors. ...
Breaking Medicine News(10 mins):
(Date:10/4/2017)... Oct. 4, 2017  South Korean-based healthcare product Development ... aide "cprCUBE" on Kickstarter. The device will educate the ... arrests with better efficiency compared to the dated and ... feedback on efficacy of the compression for a more ... a goal to raise $5,000. ...
(Date:10/2/2017)... Oct. 2, 2017  AllianceRx Walgreens Prime, the combined ... Walgreens and pharmacy benefit manager Prime Therapeutics LLC (Prime), ... which included the unveiling of new signage at its ... well as at a few other company-owned facilities across ... to patients, some of whom will begin to see ...
(Date:9/27/2017)... 27, 2017  Commended for their devotion to personalized service, ... as number one in the South Florida Business Journal,s 50 ... 5000 yearly list, the national specialty pharmacy has found its ... will soon be honored by SFBJ as the 2017 ... Set to receive his award in October, Bardisa said ...
Breaking Medicine Technology: