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Study validates Pittsburgh Compound-B in identifying Alzheimer's disease brain toxins
Date:3/26/2008

pare what we detected during her life to what we confirmed after her death. The findings from our study of her brain, coupled with the further confirmation of the other 27 brains, tell us without a doubt that PiB binds to beta-amyloid and that it is a reliable indicator of the presence of Alzheimers disease in those who are suffering its cruel effects, said Dr. Klunk.

This work is an important step forward in the development of new tools for both research and clinical care, noted Neil Buckholtz, Ph.D., chief of the Dementias of Aging Branch of the National Institute on Aging, National Institutes of Health, which supported the study. It provides additional evidence validating the use of PiB to identify beta-amyloid deposits in living individuals and advancing the potential use of PiB as an outcome measure in clinical trials of anti-beta-amyloid therapeutics.

It is estimated that up to 4.5 million people in the United States have Alzheimers, including 50 percent of those older than age 85 and 10 percent of those over age 65. The number of those affected is expected to triple over the next 50 years.


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Contact: Gloria Kreps
KrepsGA@upmc.edu
412-647-3555
University of Pittsburgh Schools of the Health Sciences
Source:Eurekalert

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