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Study validates Pittsburgh Compound-B in identifying Alzheimer's disease brain toxins
Date:3/26/2008

PITTSBURGH, March 26 A groundbreaking study conducted by University of Pittsburgh Alzheimers disease researchers reported in the journal Brain (currently online) confirms that Pittsburgh Compound-B (PiB) binds to the telltale beta-amyloid deposits found in the brains of patients with Alzheimers disease. The finding is a significant step toward enabling clinicians to provide a definitive diagnosis of Alzheimers disease in living patients. For a free-access link to the PDF version of the online article, please click here.

Until now, the beta-amyloid deposits to which PiB binds have been confirmed, without question, only in the autopsied brains of patients afflicted with Alzheimers. The new findings, which correlate PiB-identified beta-amyloid deposits from living patients to their post-mortem autopsy results, will ultimately aid in the early diagnosis of Alzheimers, help clinicians monitor the progression of the disease and further the development of potential treatments.

This is final confirmation of what we have believed all along that Pittsburgh Compound-B allows us to accurately assess the amount of beta-amyloid plaques in brains of people afflicted with Alzheimers, said senior author Steven DeKosky, M.D., professor of neurology, psychiatry, neurobiology and human genetics and director of the Alzheimers Disease Research Center at the University of Pittsburgh.

Invented and developed by Pitt researchers Chester Mathis, Ph.D., professor of radiology and pharmaceutical sciences, and William Klunk, M.D., Ph.D., professor of psychiatry and neurology, PiB is a radioactive compound that, when coupled with positron emission tomography (PET) imaging, can be injected into the bloodstream to enable researchers to visualize the brains of people with the memory-stealing illness and see the location and distribution of the beta-amyloid plaque d
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Contact: Gloria Kreps
KrepsGA@upmc.edu
412-647-3555
University of Pittsburgh Schools of the Health Sciences
Source:Eurekalert

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