Navigation Links
Study urges caution with lenalidomide dosage
Date:8/8/2011

COLUMBUS, Ohio An early phase multiple myeloma trial has unexpectedly revealed that the drug lenalidomide interacts with another protein in cells that affect its dose level in the body, say researchers at the Ohio State University Comprehensive Cancer Center Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC James) who conducted the study.

Lenalidomide is an anti-inflammatory drug, and more than 390 clinical trials have been initiated to study its activity in a number of cancers and other diseases.

The study found that lenalidomide interacts with P-glycoprotein (Pgp), a molecule that pumps potentially toxic chemicals out of cells and aids in removing these chemicals from the body. Abnormally high levels of Pgp in cancer cells can be an important cause of drug resistance for many cancer patients.

The findings, published online in the Journal of Clinical Oncology, could lead to safer dosing of lenalidomide in a variety of diseases.

"This is the first report showing that lenalidomide interacts with Pgp, and our clinical data suggests this may be an important consideration for proper dosing of the drug," says study leader and researcher Dr. Mitch Phelps, assistant professor in Ohio State's College of Pharmacy. "Some toxicities induced by lenalidomide can be severe and life-threatening."

The phase I clinical trial, which evaluates the safety of a new drug or drug combination, involved 21 patients with relapsed multiple myeloma, a fatal disease that affects more than 20,000 Americans each year and kills more than 10,600 of them.

The trial combined lenalidomide with temsirolimus, a drug that the researchers knew from the start interacted with Pgp. During the study, lenalidomide levels in patients' blood were often higher than expected, and some patients experienced side effects such as electrolyte imbalances and rashes that were greater than expected.

To the investigators' surprise, laboratory expe
'/>"/>

Contact: Darrell E. Ward
Darrell.Ward@osumc.edu
614-293-3737
Ohio State University Medical Center
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Trying Out New Identities Key to Video Games Appeal: Study
2. Frequent Tests Help Track Progression of Glaucoma, Study Finds
3. Life-Threatening Leg Clots Run in Families, Study Shows
4. Hospitals Vary Widely in Rate of Heart Procedures: Study
5. Distance caregivers for advanced cancer patients have special needs, CWRU study finds
6. Study: Graphic warning labels reduce demand for cigarettes
7. Study of Bone Cancer in Dogs May Improve Treatment in Kids
8. Men have overly optimistic expectations about recovery from prostate cancer surgery, U-M study finds
9. New study helps clarify symptoms and characteristics of acid reflux in neonates
10. Penn study finds more effective approach against Achilles heel of ovarian cancer
11. Gene Study Identifies Non-Hereditary Links to Schizophrenia
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)... Minn. (PRWEB) January 22, 2015 Blue Cross ... those Minnesotans who exemplify what it means to “Live Fearless.” ... chance for people to share their stories about how they ... or simply inspired others by living in the moment. By ...
(Date:1/22/2015)... 2015 Thousand of GranuFlo lawsuits ( ... its GranuFlo and NaturaLyte dialysis concentrates continue to move ... District Court, District of Massachusetts, Bernstein Liebhard LLP reports. ... has remanded a case filed by the state of ...
(Date:1/22/2015)... January 22, 2015 A study ... Medicine flagship journal Medicine & Science in Sports ... exercise may help reduce gastrointestinal (GI) problems associated ... , Participants in the double-blind, placebo-controlled study took ...
(Date:1/22/2015)... Payday lending practices in four southern states worsen ... to the states that permit them, according to a ... Race and Wealth. , While they generate hundreds of ... the same time substantially depress economic activity, according to ...
(Date:1/22/2015)... 22, 2015 Lower-Auto-Insurance.com has released a new blog ... a car for reducing the costs of an auto insurance ... be able to get lower prices for their vehicle insurance policies. ... role in determining policy costs. Because of this, drivers should ...
Breaking Medicine News(10 mins):Health News:Blue Cross and Blue Shield of Minnesota to Showcase “Faces of Fearless” 2Health News:Court Overseeing Federal GranuFlo Lawsuits Remands Louisiana Claim Back to State Court, Bernstein Liebhard LLP Reports 2Health News:Court Overseeing Federal GranuFlo Lawsuits Remands Louisiana Claim Back to State Court, Bernstein Liebhard LLP Reports 3Health News:Court Overseeing Federal GranuFlo Lawsuits Remands Louisiana Claim Back to State Court, Bernstein Liebhard LLP Reports 4Health News:Study Shows Kyowa Hakko’s L-Citrulline May Help Reduce Gastrointestinal Injury During Strenuous Exercise 2Health News:Study Shows Kyowa Hakko’s L-Citrulline May Help Reduce Gastrointestinal Injury During Strenuous Exercise 3Health News:Howard University Spotlights the Economic Impact of Payday Lending in Southern States 2Health News:Driving Safe And Other Factors That Make Auto Insurance Affordable! 2
... painkillers, especially the likes of Ibuprofen and Aspirin, which come ... out or exercise. A new study has suggested that the ... work out, may ease muscle pain by 50%. ... of kinesiology at the University of Georgia, Athens, 'A lot ...
... is only too happy to perform it. ... had been diagnosed with X-linked lymphoproliferative syndrome, //a rare genetic ... affected around 100 males worldwide. ,Life expectancy ... causes the immune system to respond abnormally to some viral ...
... San Antonio, Texas has come to the rescue of a ... choice. ,This clinic aids couples who are interested ... to choose the egg //and sperm donors. The couple after ... adults decides accordingly. The complete history of the donors is ...
... books, including old and rare manuscripts on the ancient Indian ... be built at the National Ayurveda Institute at a cost ... biggest ayurveda libraries in India. It will house national and ... information under one roof. ,'The budget has already ...
... at Monash University in Australia have developed a process for ... without any moving parts, potentially allowing doctors //to do blood ... new method uses the same principle that causes tea leaves ... stirred teacup, a phenomenon first explained by Einstein in the ...
... Publishing are excited to announce the publication of the ... issue of Wound Repair and Regeneration (WRR), the premier ... continued interest by the WHS membership and with a ... developed to establish guidelines for the treatment of chronic ...
Cached Medicine News:Health News:Work-outs, Not So Much of a ‘pain’ With Caffei 2Health News:Big Brother to the Rescue 2Health News:Einstein's Tea Leaves Inspire New Blood Separation Technique 2
(Date:1/23/2015)... , Jan. 23, 2015 A lot of discussion in ... for treating  certain illnesses, injuries, or conditions. As medical science ... treatment methods with ones that they consider to be more ... is not one textbook method of treatment that stands out ...
(Date:1/23/2015)... , Jan. 23, 2015  A new analysis of ... D 2015 enrollment data shows that 81 percent of ... access and extra discounts at certain pharmacies. The findings ... "Preferred pharmacy plans are now the foundation of Medicare ...
(Date:1/23/2015)... 2015 More than a third of reproductive-aged women enrolled ... private insurance, filled a prescription for an opioid pain medication ... week,s Morbidity and Mortality Weekly Report (MMWR). ... moderate to severe pain.  They are also found in some ...
Breaking Medicine Technology:No One-Size-Fits-All Remedy for Hernia Correction 2New Analysis: 81 Percent of Medicare Part D Seniors Choose "Preferred Pharmacy" Plans in 2015 2Opioid painkillers widely prescribed among reproductive age women 2Opioid painkillers widely prescribed among reproductive age women 3
... Calif. , June 3 Alexza Pharmaceuticals, Inc. (Nasdaq: ALXA ... will present during the Jefferies 2010 Global Life Sciences Conference.  The Alexza presentation ... ET .  The presentation will be webcast from the Grand Hyatt Hotel in ... , To ...
... ViroPharma Incorporated (Nasdaq: VPHM ) today announced that William Roberts ... Global Life Sciences Conference at 4:00 P.M. ET on Wednesday, ... in New York City . , ... Mr. Roberts also will present at the ThinkEquity Healthcare Conference at 1:30 ...
Cached Medicine Technology:Alexza Pharmaceuticals to Present at Jefferies 2010 Global Life Sciences Conference 2Alexza Pharmaceuticals to Present at Jefferies 2010 Global Life Sciences Conference 3ViroPharma to Participate in Two June Healthcare Investor Conferences 2
... ENA assays can be used to ... antibodies, which are associated with various ... lupus erythematosus (Lupus), Sjgren's syndrome, mixed ... scleroderma, polymyositis, dermatomyositis, and Raynaud's phenomenon. ...
... commonly prescribed for the prevention of life threatening ... However, a number of studies have shown that ... aspirin therapy to prevent a recurrent vascular event ... These people are at greater risk for a ...
... System is an embolic protection device that ... debris that may be dislodged during interventional ... components. The first is a guidewire-mounted filter, ... Other ancillary components supplied with the system ...
... is a simulator for intraocular surgery. The ... surgeon the feeling that he is experiencing ... surgeon uses instruments that feel and function ... through the EYESI microscope is similar to ...
Medicine Products: