Navigation Links
Study unveils new approach to treating brittle bone disease
Date:5/4/2014

HOUSTON (May 4, 2014) Researchers at Baylor College of Medicine have identified a new approach to treating brittle bone disease, a congenital disorder that results in fragile bones that break easily.

The study, published in the current issue of the journal Nature Medicine, showed that excessive activity of an important signaling protein in the matrix of the bone called transforming growth factor beta is associated with the cause of the disease.

"There are many genetic causes of brittle bone disease in children and adults," said Dr. Brendan Lee, professor of molecular and human genetics at Baylor and a Howard Hughes Medical Institute investigator. "We have discovered many of them but clinicians still cannot easily distinguish the different forms."

Lee said the new study suggested that there may be common mechanisms that cause the decreased quality and quantity of bone in these different forms.

"This identified an important concept in bone disease that while many different genetic mutations can affect the proteins in the bone matrix (like collagen) they act in a common pathway to cause the bone disease that is they affect how signaling proteins called transforming growth factor beta (TGF) are delivered to cells in the bone," said Lee. "We now have a deeper understanding for how genetic mutations that affect collagen and collagen processing enzymes cause weak bones."

Collagen is the most common protein in the human body, and the four most common types are found in different types of tissues including bone, cartilage, blood vessels, and kidney.

In animal studies, Lee and his colleagues showed that blockade of the TGF proteins using an antibody could restore the quantity of bone in mice with different forms of brittle bone disease.

"This treatment appears even more effective than other existing approaches," said Lee.

There are currently drugs in development to block this pa
'/>"/>

Contact: Glenna Picton
picton@bcm.edu
713-798-4710
Baylor College of Medicine
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Study points to potential revision of treatment guidelines for bleeding ulcers
2. Study examines effect of receiving Tdap vaccine during pregnancy
3. Study explores why gay, lesbian teens binge drink
4. Study shows lower verbal test score for toddlers who play non-educational games on touch screens
5. UH Rainbow to study African-Americans response to asthma medications
6. Study shows link between sleep apnea and hospital maternal deaths
7. Vanderbilt study explores genetics behind Alzheimers resiliency
8. Study: Custom-made mouthguards reduce athletes risk of concussion
9. Study: Low-fat diet helps fatigue in people with MS
10. Space Station study seeks how plants sense up and down
11. Study confirms increased prevalence of GI symptoms among children with autism
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/4/2015)... March 04, 2015 With the growing influence ... lives of our teens and young adults, combined with the ... and confusing to try to keep up with what kids ... or trend is replaced on a daily basis. , The ... and the slang that is used to discreetly talk about ...
(Date:3/4/2015)... BC (PRWEB) March 04, 2015 Starting ... perform LASIK and PRK procedures at their new location ... Correction, Dr. Joseph King and Dr. Gabriel Chu also ... practice in Surrey is named Fraser Valley Cataract and ... is accredited by the College of Physicians and Surgeons ...
(Date:3/4/2015)... New York, NY (PRWEB) March 04, 2015 ... within the centerfold of The San Francisco Chronicle with ... readership of 500,000 readers. Its digital component is distributed ... a network of top news sites and partner outlets. ... click here. , Milorganite is composed of ...
(Date:3/4/2015)... 04, 2015 As seen on ... can be a painful condition in which the ... of the uterus leading to very unpleasant symptoms and ... can have a terrible effect on women’s quality of ... the most common cause of infertility in women and ...
(Date:3/4/2015)... (PRWEB) March 04, 2015 The popular ... of their new L-Style Revolution™ Program. The customized program ... and women of all health and fitness levels to ... goals faster than traditional methods. , “We’re really proud ... customized plans based on award winning techniques to help ...
Breaking Medicine News(10 mins):Health News:Per Wickstrom Offers Guide to Parents for Keeping Youth Sober 2Health News:King LASIK relocates to Surrey, British Columbia 2Health News:Advanced Fertility Center of Texas Brings Awareness to the Month of March-Endometriosis Awareness Month 2Health News:Advanced Fertility Center of Texas Brings Awareness to the Month of March-Endometriosis Awareness Month 3Health News:The Makers of Liporidex, The Popular Sports Nutrition Supplement Brand, Launches Its New L-Style Revolution™ Diet & Exercise Program That Promises Turbo Charged Results 2
... gum disease , , WEDNESDAY, Dec. 12 (HealthDay News) ... and a weakened immune response may be to blame, ... In experiments with mice infected with the bacteria ... battle gum infection than their normal-weight counterparts, according to ...
... 12 CG Technology has changed its,name to ... depth,and breadth of services it offers. Carlisle & ... standards of work, while focusing its,business on the ... Consulting Group (CG) is a management consulting,and project-based ...
... System Detects Illegal Payments and Providers, AUSTIN, ... and an NBC News report, U.S. taxpayers are ... to unqualified doctors and health,care providers. A new ... however, can make a significant impact on reducing ...
... ATS Medical, Inc.,(Nasdaq: ATSI ), manufacturer ... today announced that James L. Cox, M.D. has,agreed ... Cox, reputation as a,preeminent authority in the surgical ... serves as the foundation for ATS 3f(R),tissue valve ...
... We are encouraged by the,positive results of the ... D.C., showing promising strides in the right direction,with significant ... of a larger trend for all measured age groups ... past six years (2001-2007)., MTF, now in its ...
... presents $5,000 each to six community organizations in ... underserved areas, ... it will provide a total of $30,000 in end of,year donations to ... given to six agencies in northern and,southern California to assist vulnerable populations., ...
Cached Medicine News:Health News:Obesity Weakens Immune Response 2Health News:Technology can Dramatically Reduce Billions of Dollars in Medicaid, Medicare Fraud 2Health News:ATS Medical Appoints James L. Cox, M.D. as Medical Director 2Health News:ATS Medical Appoints James L. Cox, M.D. as Medical Director 3Health News:Statement of Steve Pasierb, President and CEO, Partnership for a Drug-Free America on the Release of the 2007 Monitoring the Future Study 2Health News:Statement of Steve Pasierb, President and CEO, Partnership for a Drug-Free America on the Release of the 2007 Monitoring the Future Study 3Health News:Statement of Steve Pasierb, President and CEO, Partnership for a Drug-Free America on the Release of the 2007 Monitoring the Future Study 4Health News:Blue Cross of California Gives $30,000 in Holiday Donations to Food Banks Throughout the State 2
(Date:3/4/2015)... , March 4, 2015  Mail-service and specialty ... consumers, employers and government health plans $11.8 billion ... by the Pharmaceutical Care Management Association (PCMA). ... offers one of the easiest ways to reduce ... Mark Merritt . "Policymakers should resist efforts to ...
(Date:3/4/2015)... UPM Pharmaceuticals, a division of Gregory Pharmaceutical ... to manufacture Flibanserin 100 mg tablets. Sprout has submitted ... drug approved to treat hypoactive sexual desire disorder (HSDD), ... The tablets will be manufactured at UPM,s 475,000 ... . Dr. John M. Gregory , ...
(Date:3/4/2015)... 2015   Aratana Therapeutics, Inc . (NASDAQ: ... the licensing, development and commercialization of innovative biopharmaceutical products ... at the Barclays Global Healthcare Conference to ... Beach Hotel in Miami , FL.  ... President and Chief Executive Officer of Aratana Therapeutics, will ...
Breaking Medicine Technology:PCMA: Report Shows High-Tech Specialty and Mail-Service Pharmacies Will Reduce Costs for Illinois Employers, Consumers and Public Programs by $11.8 Billion 2UPM Pharmaceuticals to Manufacture Sprout Pharmaceuticals' Flibanserin Tablets 2UPM Pharmaceuticals to Manufacture Sprout Pharmaceuticals' Flibanserin Tablets 3Aratana Therapeutics to Present at the Barclays Global Healthcare Conference 2
... 25, 2007 /PRNewswire-FirstCall/ --,Phosphagenics Limited (AIM: PSG) announced ... dermal drug delivery,technology formulated with retinoic acid, a ... ingredient used in,anti-aging cosmetics. , The proof of ... of retinoic acid delivered into the skin when ...
... Pfizer announced today,that Lipitor (atorvastatin calcium) Tablets 80 ... events and major coronary events,in type 2 diabetes ... who had experienced a recent stroke or mini-stroke, ... analysis of the landmark,Stroke Prevention by Aggressive Reduction ...
Cached Medicine Technology:Phosphagenics Announces Positive Proof of Concept Results from,Studies Utilizing Company's Dermal Drug Delivery Technology 2Lipitor Reduced the Risk of Coronary Events by Half and Stroke by,Nearly One-Third in High-Risk Patients with Type 2 Diabetes Who,Experienced a Recent Stroke 2Lipitor Reduced the Risk of Coronary Events by Half and Stroke by,Nearly One-Third in High-Risk Patients with Type 2 Diabetes Who,Experienced a Recent Stroke 3
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
Medicine Products: