Navigation Links
Study unmasks how ovarian tumors evade immune system
Date:12/1/2008

Scientists at Johns Hopkins have determined how the characteristic shedding of fatty substances, or lipids, by ovarian tumors allows the cancer to evade the body's immune system, leaving the disease to spread unchecked. Ovarian cancer is considered to be one of the most aggressive malignancies, killing more than 70 percent of diagnosed women within five years, including an estimated 15,000 this year.

In a two-year series of lab experiments, a team of researchers from the Johns Hopkins University School of Medicine and its Sidney Kimmel Comprehensive Cancer Center showed that fluid secretions from tumors, called ascites, which contain lipids and collect in the space surrounding cancerous ovaries, can totally suppress the action of natural killer T cells in the immune system.

Known as NKTs for short, these special T cells must be activated to do their job of jump-starting the immune response and signaling other kinds of white blood cells to rid the body of diseases or leave healthy tissue alone.

As part of the study, researchers collected lipid-filled ascites from 25 women with ovarian cancer and then exposed the lipid samples to an immune system test to see if they blocked activation of NKT cells.

In a report set to appear in the Dec.1 issue of the journal Clinical Cancer Research, the research team also found this evasive blocking tactic to be virtually exclusive to a specific protein, called CD1d, needed to activate the NKT cells.

Their experiments specifically showed that NKT activation was blocked between 10 percent and 100 percent after test cultures of cells that stimulate NKT cells were exposed to increasing concentrations of tumor-derived ascites.

Disrupted or stalled T cell action has been known to play a key role in the spread of several kinds of cancer, the scientists say. But until now, there was no firm evidence that tied a specific T cell in the body's defensive immune system to ovaria
'/>"/>

Contact: David March
dmarch1@jhmi.edu
410-955-1534
Johns Hopkins Medical Institutions
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Study shows how shift workers can improve job performance and implement a realistic sleep schedule
2. Study Recruiting From Alzheimers-Prone Families
3. Aged care workers to leave industry en masse due to stress, warns University of Melbourne study
4. Study compares strategies for BK virus nephropathy
5. Study: Childhood constipation just as serious as asthma
6. Stanford/Packard study shows no benefit from drug widely used to prevent premature births
7. Pulmonary Hypertension Treated with Stem Cells : International Medical Team Announces Patient Results in Adult Stem Cell Clinical Study for Pulmonary Hypertension
8. Study: Want to be happier? Be more grateful
9. Study Calls for Greater Scrutiny of Off-Label Drug Use
10. Study suggests reliability of cognitive assessment tool varies widely
11. Study identifies double-balloon enteroscopy as cost-effective approach for obscure GI bleeding
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/22/2014)... Amy Norton HealthDay Reporter ... remain riveted on the three Ebola cases in Dallas. But, ... health threat to Americans. President Barack Obama on Friday ... the virus, which has infected two Dallas nurses who cared ... at Texas Health Presbyterian Hospital. But the U.S. cases ...
(Date:10/22/2014)... 2014 Shriners Hospitals for Children® and ... the current location of Shriners Hospitals for Children - ... from the University of Kentucky Albert B. Chandler Hospital. ... center, owned and operated by Shriners Hospitals for Children, ... children and their families well into the future. , ...
(Date:10/22/2014)... (PRWEB) October 22, 2014 Hay House is ... Beyond Addiction and Upgrade Your Life (Paperback; $10.82) written by ... Yoga & Recovery. This book is meant to help ... a life of recovery. , Recovery 2.0 is not ... Steps; Recovery 2.0 is a guide for what comes next. ...
(Date:10/22/2014)... 2014 During the Western United States’ ... runs dangerously low, Southern Oregon’s water is proving resistant ... the lowest mountain snow pack on record in 2014, ... early autumn.* That was the observation of journalist-hikers Art ... “Hiking Southern Oregon,” during an interview with water advocate ...
(Date:10/22/2014)... Texas (PRWEB) October 22, 2014 ... of completing their continuing education at home or ... have access to 20 brand new, premium Seminar-on-Demand ... robust catalog of over 2,000 hours ... fully customize their educational experience. With such a ...
Breaking Medicine News(10 mins):Health News:Ebola Anxiety: A Bigger Threat Now Than the Virus Itself 2Health News:Ebola Anxiety: A Bigger Threat Now Than the Virus Itself 3Health News:Shriners Hospitals for Children - Lexington Announces Plan to Build New $47 Million Facility 2Health News:Shriners Hospitals for Children - Lexington Announces Plan to Build New $47 Million Facility 3Health News:Hay House Announces The Official Release of Recovery 2.0: Move Beyond Addiction and Upgrade Your Life 2Health News:Hay House Announces The Official Release of Recovery 2.0: Move Beyond Addiction and Upgrade Your Life 3Health News:Southern Oregon Is West’s Most Drought Proof Fresh Water Region Say Hiking Guide Authors 2Health News:Southern Oregon Is West’s Most Drought Proof Fresh Water Region Say Hiking Guide Authors 3Health News:Southern Oregon Is West’s Most Drought Proof Fresh Water Region Say Hiking Guide Authors 4Health News:Top Provider of Continuing Education at Home Releases 20 New Online Courses 2
... may come to the therapeutic aid of chronic lower ... The School of Materials// and Professor Tony Freemont from ... ,The tiny gel particles discovered by the team are ... damaged region. This study was performed on the bovine ...
... paucity of anesthesiologists in the province of Ontario, evident in ... tide over such a situation, Ontario has created two additional ... times for patients. This strategy has proved its weight in ... time tested measure to improve patient care. ...
... Guidelines for Americans recommends at least two servings of ... ,Two recent studies find that Americans are not eating ... health concern because consuming a diet high in fruits ... and certain chronic diseases, such as cardiovascular disease, diabetes ...
... nearly nine million people around the world suffer Tuberculosis, ... behind the notorious lung disease was discovered more than ... March 24th, also The World Tuberculosis Day, we are ... vanquished. ,Experts are particularly disappointed with the ...
... facts and figures has shown the dangerous increase in Type ... The number of children below five years of age, battling ... between 1985 and 2004. ,Type 1 diabetes or ... as opposed to Type 2 diabetes, which develops much later. ...
... of the southern Indian state of Kerala, have said that ... the death of the three partying youngsters, including a girl in ... recovered from a closed garage, by the side of a car ... city. ,The police now say that the youngsters ...
Cached Medicine News:Health News:Eat Fruits- Keep Diseases at Bay 2Health News:Eat Fruits- Keep Diseases at Bay 3Health News:Kerala Youth Die of Carbon Monoxide Inhalation 2
(Date:10/22/2014)... -- Charlene Vernak, RPh, of Vernak Farms Pharmacy in ... the George Roentsch Scholarship by the Professional Compounding Centers ... Houston during PCCA,s International Seminar, held ... an independent pharmacist and PCCA member who embodies the ... a well-known pharmacist in the compounding community. ...
(Date:10/22/2014)... -- Moms are ready to live the "measured life" ... kids, according to the results of the BabyCenter® U.S. ... for Moms, the latest installment in BabyCenter,s 21 st ... and parenting web and mobile destination worldwide, conducted the ... say they can,t think of a reason not to ...
(Date:10/22/2014)... , Oct. 22, 2014 AVACEN Medical ... device received 510 (k) OTC clearance by the U.S. ... 100 to be marketed over the Internet for: ... muscle spasms; and minor strains and sprains . ... The AVACEN 100 (MSRP $2495) is a sophisticated medical ...
Breaking Medicine Technology:PCCA Awards Charlene Vernak, RPh, the George Roentsch Scholarship 2BabyCenter Finds Mom Ready to Live the "Measured Life" in its U.S. Mobile Mom 2014 Report: Health & Fitness Go Mobile for Moms 2BabyCenter Finds Mom Ready to Live the "Measured Life" in its U.S. Mobile Mom 2014 Report: Health & Fitness Go Mobile for Moms 3BabyCenter Finds Mom Ready to Live the "Measured Life" in its U.S. Mobile Mom 2014 Report: Health & Fitness Go Mobile for Moms 4AVACEN Medical Announces FDA Clearance of First Medical Device with Internal Game Mode 2
... HARBIN, China , July 23 /PRNewswire-Asia-FirstCall/ -- China ... CSKI ), a,leading fully integrated pharmaceutical company in the ... obtained approval from the,State Food and Drug Administration (SFDA) in ... number for this drug is,H20103320. , ...
... LOS GATOS, Calif. , July 22, 2010 ... filed amendments to its Certificate of Incorporation effective as of ... 1-for-5,000 reverse stock split, pursuant to which shareholders owning fewer ... shares cancelled and converted into the right to receive ...
Cached Medicine Technology:China Sky One Medical Obtains SFDA Approval for Ciclopirox Olamine Vaginal Suppositories 2China Sky One Medical Obtains SFDA Approval for Ciclopirox Olamine Vaginal Suppositories 3NOVT Corporation Completes Reverse/Forward Stock Split 2
... Stealthstation Siremobil Iso-C3D C-Arm imaging system interface ... of mobile C-arm imaging. Combining mobility ... software, the cooperative technologies deliver the most ... 3D imaging is the new standard in ...
... The best of digital mobile imaging ... of,anatomical localization software and instrumentation. Now ... capability to:, Easily Add Visualization ... Dose, Accelerate Intraoperative Decision Making, ...
... the most advanced imaging capabilities into the ... it offers many of the same technologies ... value-oriented platform. Asteion provides the subsecond speed ... scanning, while also supporting everyday, high-resolution scanning ...
... the T.L.I.F. SG Instruments are the ... surgery, offering comprehensive and functionally sound instruments.. ... variety of disc removal and disc preparation ... TLIF procedure. Excellent design, a wide range ...
Medicine Products: