Navigation Links
Study uncovers new cells in the urethra which may detect hazardous substances

Arnhem, 11 March 2013- A recent study conducted by a group of German scientists revealed the presence of a previously unknown cell in the urethra of mice. These chemosensory cholinergic brush cells are in close contact to sensory neurons that express cholinergic receptors.

The authors suggest that in analogy to brush cells of the respiratory tract, the urethral brush cells may also serve as sentinels being able to detecting hazardous substances and preventing their further retrograde ingression.

The results of this investigation will be presented at the upcoming 28th Annual EAU Congress which will kick off this Friday in Milan. The study won 2nd Prize for Best Abstract in Non-Oncology.

"Urinary tract infections rate among the most common indispositions among out- as well as in-patients and are chiefly triggered by bacteria entering the body through the urethra. We here discovered a previously not recognised cell which surveils this portal of entry," commented the presenting author of the study, Ms. Katharina Filipski of the Anatomy and Cell Biology Department at Justus-Liebig-University Giessen in Germany.

"A further exploration of this cell population will provide insight into cellular interaction and defensive measures against pathogens."

According to the authors, cholinergic chemoceptive cells might play an essential role in detecting and defending microorganisms invading the body through the urethra. The maintenance and support of their protective function could fortify the immune barrier and prevent urinary tract infections by initiating avoiding reflexes as micturition.

"It is also conceivable that dysfunction of this system might result in inappropriate urge, thereby being linked to overactive bladder," explained Ms. Filipski.

During the study, the detection and characterisation of chemosensory brush cells of the murine urethra was addressed by means of ultrastructural immunohistochemistry, confocal laser scanning microscopy (CLSM) analysis and 3D-reconstruction, immunofluorescence, RT-PCR, and measurement of intracellular calcium concentration.

According to Ms. Filipski, the results of the study promote further research into the subject matter.

"Together with the urological clinic of our university, we now aim to unravel the reflexes initiated after the detection of bacteria by the chemoceptive cholinergic cells. This will be addressed by cystomanometry of mice after urethral exposure to bacterial components."


Contact: Ivanka Moerkerken
European Association of Urology

Related medicine news :

1. Surgery is superior to radiotherapy in men with localized PCa, says prize-winning Swedish study
2. New study on UTIs suggests flagellin is key in stimulating bodys natural defences
3. Japanese P2 study shows potential of combined vaccine and steroid drug in castration resistant PCa
4. Study shows additional role for abiraterone in blocking tumor growth in CRPC
5. Study: 15% of Children Ages 10 - 14 Consider Using Steroids; polyDNA Recommends Muxscle for Safe Muscle Building
6. Blacks With Kidney Disease Should Watch for Blood Pressure Shifts: Study
7. Study of dragonfly prey detection at MBL wins PNAS Cozzarelli Prize
8. Study shows how vitamin E can help prevent cancer
9. Autism Speaks trailblazer study -- Blocking cell distress signals can ease autism symptoms
10. Clot Buster Safe for Stroke Patients on Blood Thinners: Study
11. Study: Dynamic new software improves care of aging brain
Post Your Comments:
(Date:6/25/2016)... ... June 25, 2016 , ... Conventional wisdom preaches the benefits ... terms of the latter, setting the bar too high can result in disappointment, perhaps ... slow progress toward their goal. , Research from reveals that ...
(Date:6/24/2016)... ... June 24, 2016 , ... June 19, 2016 is ... associated with chronic pain and the benefits of holistic treatments, Serenity Recovery Center ... suffering with Sickle Cell Disease. , Sickle Cell Disease (SCD) is a disorder of ...
(Date:6/24/2016)... ... 2016 , ... Global law firm Greenberg Traurig, P.A. announced that 20 Florida ... their peers for this recognition are considered among the top 2 percent of lawyers ... as members of this year’s Legal Elite Hall of Fame: Miami Shareholders Mark ...
(Date:6/24/2016)... ... June 24, 2016 , ... Topical BioMedics, Inc, makers of Topricin and MyPainAway Pain Relief Products, ... minimum wage raise to $12 an hour by 2020 and then adjusting it yearly to ... value of the minimum wage, assure the wage floor does not erode again, and make ...
(Date:6/24/2016)... ... 24, 2016 , ... The Haute Beauty Network, affiliated with ... as a prominent plastic surgeon and the network’s newest partner. , Dr. ... handsome men, look naturally attractive. Plastic surgery should be invisible.” He stands by ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... SOUTH SAN FRANCISCO, Calif. , June 24, ... GBT ), a biopharmaceutical company developing novel ... with significant unmet needs, today announced the closing ... 6,400,000 shares of common stock, at the public ... the shares in the offering were offered by ...
(Date:6/24/2016)... June 24, 2016 The Academy of Managed ... recommendations that would allow biopharmaceutical companies to more ... that make formulary and coverage decisions, a move that ... new medicines. The recommendations address restrictions in ... on the drug label, a prohibition that hinders decision ...
(Date:6/24/2016)... , June 24, 2016 According ... by Type (Standard Pen Needles, Safety Pen Needles), Needle ... GLP-1, Growth Hormone), Mode of Purchase (Retail, Non-Retail) - ... This report studies the market for the forecast period ... reach USD 2.81 Billion by 2021 from USD 1.65 ...
Breaking Medicine Technology: