Navigation Links
Study uncovers new cells in the urethra which may detect hazardous substances
Date:3/15/2013

Arnhem, 11 March 2013- A recent study conducted by a group of German scientists revealed the presence of a previously unknown cell in the urethra of mice. These chemosensory cholinergic brush cells are in close contact to sensory neurons that express cholinergic receptors.

The authors suggest that in analogy to brush cells of the respiratory tract, the urethral brush cells may also serve as sentinels being able to detecting hazardous substances and preventing their further retrograde ingression.

The results of this investigation will be presented at the upcoming 28th Annual EAU Congress which will kick off this Friday in Milan. The study won 2nd Prize for Best Abstract in Non-Oncology.

"Urinary tract infections rate among the most common indispositions among out- as well as in-patients and are chiefly triggered by bacteria entering the body through the urethra. We here discovered a previously not recognised cell which surveils this portal of entry," commented the presenting author of the study, Ms. Katharina Filipski of the Anatomy and Cell Biology Department at Justus-Liebig-University Giessen in Germany.

"A further exploration of this cell population will provide insight into cellular interaction and defensive measures against pathogens."

According to the authors, cholinergic chemoceptive cells might play an essential role in detecting and defending microorganisms invading the body through the urethra. The maintenance and support of their protective function could fortify the immune barrier and prevent urinary tract infections by initiating avoiding reflexes as micturition.

"It is also conceivable that dysfunction of this system might result in inappropriate urge, thereby being linked to overactive bladder," explained Ms. Filipski.

During the study, the detection and characterisation of chemosensory brush cells of the murine urethra was addressed by means of ultrastructural immunohistochemistry, confocal laser scanning microscopy (CLSM) analysis and 3D-reconstruction, immunofluorescence, RT-PCR, and measurement of intracellular calcium concentration.

According to Ms. Filipski, the results of the study promote further research into the subject matter.

"Together with the urological clinic of our university, we now aim to unravel the reflexes initiated after the detection of bacteria by the chemoceptive cholinergic cells. This will be addressed by cystomanometry of mice after urethral exposure to bacterial components."


'/>"/>

Contact: Ivanka Moerkerken
i.moerkerken@uroweb.org
31-026-389-0680
European Association of Urology
Source:Eurekalert

Related medicine news :

1. Surgery is superior to radiotherapy in men with localized PCa, says prize-winning Swedish study
2. New study on UTIs suggests flagellin is key in stimulating bodys natural defences
3. Japanese P2 study shows potential of combined vaccine and steroid drug in castration resistant PCa
4. Study shows additional role for abiraterone in blocking tumor growth in CRPC
5. Study: 15% of Children Ages 10 - 14 Consider Using Steroids; polyDNA Recommends Muxscle for Safe Muscle Building
6. Blacks With Kidney Disease Should Watch for Blood Pressure Shifts: Study
7. Study of dragonfly prey detection at MBL wins PNAS Cozzarelli Prize
8. Study shows how vitamin E can help prevent cancer
9. Autism Speaks trailblazer study -- Blocking cell distress signals can ease autism symptoms
10. Clot Buster Safe for Stroke Patients on Blood Thinners: Study
11. Study: Dynamic new software improves care of aging brain
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/29/2016)... ... 2016 , ... Since launching its annual volunteer campaign on ... footwear industry, has broken all previous participation records in its first two weeks ... during the months of April and May, the 2016 Footwear Cares initiative is ...
(Date:4/29/2016)... Newport Beach, Calif. (PRWEB) , ... April 29, 2016 , ... ... affect us. An effective way to confront and deal with these stressors is to ... taste bad to be good for you. Risa Groux, a certified Holistic Nutritionist and ...
(Date:4/29/2016)... CA (PRWEB) , ... April 29, 2016 , ... ... advocating optimistic healthcare awareness and author of best seller "LOVE, MEDICINE and MIRACLES") ... Radio Monday, May 2, 2016 and podcasted thereafter . Dr. Bernie Siegel, ...
(Date:4/29/2016)... Stewart, GA (PRWEB) , ... April 29, 2016 , ... ... Monday, May 16, 2016, at its new location in the Exchange Furniture Mall at ... a raffle for a 50-inch Samsung Smart TV. Plus attendees will have the opportunity ...
(Date:4/29/2016)... ... April 29, 2016 , ... ... won the $30,000 Perlman Grand Prize of the 2016 Wharton Business Plan ... the Michelson People’s Choice Award, and the Committee Award for Most ‘Wow Factor,’ ...
Breaking Medicine News(10 mins):
(Date:4/29/2016)... April 29, 2016  In the next ten ... shift from systems dependent on CRTs monitors to those ... modality CRT Medical monitors and will automatically sync ... host of foreseeable benefits to this technological advancement, ... modalities have to be replaced in order to ...
(Date:4/29/2016)... 29, 2016 ReportsnReports.com adds ... market research report that provides an overview of ... at various stages, therapeutics assessment by drug target, ... and molecule type, along with latest updates, and ... key players involved in the therapeutic development for ...
(Date:4/29/2016)... , April 29, 2016 ... for Life Sciences, Product Development Capabilities in ... Science Customer Base . Indegene ... today announced the acquisition of Skura Corporation,s life ... leader in adaptive sales enablement technology for life ...
Breaking Medicine Technology: