Navigation Links
Study uncovers new cells in the urethra which may detect hazardous substances
Date:3/15/2013

Arnhem, 11 March 2013- A recent study conducted by a group of German scientists revealed the presence of a previously unknown cell in the urethra of mice. These chemosensory cholinergic brush cells are in close contact to sensory neurons that express cholinergic receptors.

The authors suggest that in analogy to brush cells of the respiratory tract, the urethral brush cells may also serve as sentinels being able to detecting hazardous substances and preventing their further retrograde ingression.

The results of this investigation will be presented at the upcoming 28th Annual EAU Congress which will kick off this Friday in Milan. The study won 2nd Prize for Best Abstract in Non-Oncology.

"Urinary tract infections rate among the most common indispositions among out- as well as in-patients and are chiefly triggered by bacteria entering the body through the urethra. We here discovered a previously not recognised cell which surveils this portal of entry," commented the presenting author of the study, Ms. Katharina Filipski of the Anatomy and Cell Biology Department at Justus-Liebig-University Giessen in Germany.

"A further exploration of this cell population will provide insight into cellular interaction and defensive measures against pathogens."

According to the authors, cholinergic chemoceptive cells might play an essential role in detecting and defending microorganisms invading the body through the urethra. The maintenance and support of their protective function could fortify the immune barrier and prevent urinary tract infections by initiating avoiding reflexes as micturition.

"It is also conceivable that dysfunction of this system might result in inappropriate urge, thereby being linked to overactive bladder," explained Ms. Filipski.

During the study, the detection and characterisation of chemosensory brush cells of the murine urethra was addressed by means of ultrastructural immunohistochemistry, confocal laser scanning microscopy (CLSM) analysis and 3D-reconstruction, immunofluorescence, RT-PCR, and measurement of intracellular calcium concentration.

According to Ms. Filipski, the results of the study promote further research into the subject matter.

"Together with the urological clinic of our university, we now aim to unravel the reflexes initiated after the detection of bacteria by the chemoceptive cholinergic cells. This will be addressed by cystomanometry of mice after urethral exposure to bacterial components."


'/>"/>

Contact: Ivanka Moerkerken
i.moerkerken@uroweb.org
31-026-389-0680
European Association of Urology
Source:Eurekalert

Related medicine news :

1. Surgery is superior to radiotherapy in men with localized PCa, says prize-winning Swedish study
2. New study on UTIs suggests flagellin is key in stimulating bodys natural defences
3. Japanese P2 study shows potential of combined vaccine and steroid drug in castration resistant PCa
4. Study shows additional role for abiraterone in blocking tumor growth in CRPC
5. Study: 15% of Children Ages 10 - 14 Consider Using Steroids; polyDNA Recommends Muxscle for Safe Muscle Building
6. Blacks With Kidney Disease Should Watch for Blood Pressure Shifts: Study
7. Study of dragonfly prey detection at MBL wins PNAS Cozzarelli Prize
8. Study shows how vitamin E can help prevent cancer
9. Autism Speaks trailblazer study -- Blocking cell distress signals can ease autism symptoms
10. Clot Buster Safe for Stroke Patients on Blood Thinners: Study
11. Study: Dynamic new software improves care of aging brain
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/28/2017)... ... ... enough sleep affects much more than energy – it also has mental and physical benefits. ... motor reaction time, which can increase the risk of having a car accident. , ... the NSF to help you sleep better and feel better:, , ...
(Date:4/28/2017)... ... April 28, 2017 , ... ... http://www.wiredlifesolutions.com , “Computers are everywhere and they’re here to stay,” said ... Global Climate Change and Your Health on Voice America sponsored by Nature’s Tears® ...
(Date:4/28/2017)... (PRWEB) , ... April 28, 2017 , ... The ... board members and officers for 2017-2018. The annual board election process has been in ... a volunteer basis. , Thomas C. Dickerson, Ed.D., FACHE, succeeds Jim Hamilton, MHA, CMM, ...
(Date:4/28/2017)... ... April 28, 2017 , ... Children and adolescents who ... experiences than children in the general population. That’s because foster care is designed ... family challenges. While no fault of their own, youth who have experienced trauma ...
(Date:4/28/2017)... Harbor, Md. (PRWEB) , ... April 28, 2017 ... ... Care Association of America (UCAOA) and College of Urgent Care Medicine will host ... 2017 workshops, sessions and speakers will help those in the industry adapt to ...
Breaking Medicine News(10 mins):
(Date:4/20/2017)... 2017  AbbVie (NYSE: ABBV), a global biopharmaceutical ... chronic hepatitis C virus (HCV) infected patients with ... compensated cirrhosis (Child-Pugh A) achieved sustained virologic response ... its investigational, pan-genotypic regimen of glecaprevir/pibrentasvir (G/P). These ... 12 weeks of G/P treatment without ribavirin. Patients ...
(Date:4/20/2017)... Sweden , April 20, 2017 ... NEVPF) ("NeuroVive") today announced positive preclinical results ... preclinical compound for non-alcoholic steatohepatitis (NASH), in ... NV556 has previously shown ... NASH model. Today, NeuroVive,s scientists present novel ...
(Date:4/19/2017)... , April 19, 2017 Cardiology devices segment ... projected period The Cardiology Devices segment is likely ... US$ 15 Mn in 2018 over 2017. By the end ... market valuation close to US$ 700 Mn, expanding at a ... segment dominated the Asia Pacific reprocessed ...
Breaking Medicine Technology: