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Study uncovers cause of flu epidemics
Date:3/4/2008

The exchange of genetic material between two closely related strains of the influenza A virus may have caused the 1947 and 1951 human flu epidemics, according to biologists. The findings could help explain why some strains cause major pandemics and others lead to seasonal epidemics. Until now, it was believed that while reassortment when human influenza viruses swap genes with influenza viruses that infect birds causes severe pandemics, such as the Spanish flu of 1918, the Asian flu of 1957, and the Hong Kong flu of 1968, while viral mutation leads to regular influenza epidemics. But it has been a mystery why there are sometimes very severe epidemics like the ones in 1947 and 1951 that look and act like pandemics, even though no human-bird viral reassortment event occurred.

There was a total vaccine failure in 1947. Researchers initially thought there was a problem in manufacturing the vaccine, but they later realized that the virus had undergone a tremendous evolutionary change, said Martha Nelson, lead author and a graduate student in Penn States Department of Biology. We now think that the 1947 virus did not just mutate a lot, but that this unusual virus was made through a reassortment event involving two human viruses.

So we have found that the bipolar way of looking at influenza evolution is incorrect, and that reassortment can be an important driver of epidemic influenza as well as pandemic influenza, said Nelson, whose teams findings appear in the current issue of PLoS Pathogens. We have discovered that you can also have reassortment between viruses that are much more similar, that human viruses can reassort with each other and not just with bird viruses.

Nelson and her colleagues analyzed the evolutionary patterns in the H1N1 strain of the influenza A viruses by looking at 71 whole-genome sequences sampled between 1918 and 2006 and representing 17 different countries on five continents.

Using the genome
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Contact: Amitabh Avasthi
axa47@psu.edu
814-865-9481
Penn State
Source:Eurekalert

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