Navigation Links
Study tracks worldwide spread of beneficial blood cell gene variant
Date:7/28/2014

etics, looked at genetic factors that can reduce the severity of these blood disorders. Typically, our bodies make fetal haemoglobin whilst in the womb, but then switch to another form of haemoglobin, adult haemoglobin, at birth. However, we continue to produce very small amounts of fetal haemoglobin in adulthood, some more than others. Patients who have the genetic factors that increase fetal haemoglobin production tend to have milder symptoms of their blood disorder.

While studying patients of African and of South Asian descent, the authors noticed that one such factor, a genetic variant controlling the red blood cell regulator gene MYB - 'MYB enhancer variant' - on Chromosome 6, is of similar genetic structure not only in both patient groups, but also in healthy individuals, including those of Northern European origin, where thalassaemia and sickle cell disease are rare. This led the authors to suspect that beneficial MYB enhancer variants, which promote fetal haemoglobin in the body, are a general feature of human populations across the world and that they might have a common origin.

To test this hypothesis, the team searched for genetic signatures of such variants in public genome data generated from world populations to see whether they existed in other ethnic groups. They found signatures for two different types of MYB enhancer variants, HMIP-2A and HMIP-B, in major human population groups and in nearly all ethnic groups covered by the data. Both variants occur in Sub-Saharan Africa, but only at low frequencies. In much of the rest of the world the alleles have combined, forming HMIP-2A-B, and this combination is relatively common in Europe, South Asia and China. HMIP-2B separately is common in Far-East Asian peoples and in Amerindians, illustrating their connection across the Bering Strait.

The team also tested recent genome sequence data from our extinct cousins, the Neanderthals and Denisovans, and from the Great Apes, but d
'/>"/>

Contact: Jenny Gimpel
jenny.gimpel@kcl.ac.uk
44-020-784-84334
King's College London
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Study Suggests Vaccine May Help Kids With Brain Cancer
2. Study reveals how cancer drug causes diabetic-like state
3. Coffee Drinking in Pregnancy Wont Lead to Sleepless Baby: Study
4. Lower GI problems plague many with rheumatoid arthritis, Mayo Clinic study finds
5. Veggies Like Broccoli, Cabbage May Help Fight Breast Cancer: Study
6. No Added Cancer Risk From Hip Replacement Materials: Study
7. Reported Decline in U.S. Pneumonia Deaths May Be False: Study
8. Early Study Finds Some Promise for Lung Cancer Vaccine
9. Narcissists Often Ace Job Interviews, Study Finds
10. Sexual objectification of female artists in music videos exists regardless of race, MU study finds
11. Soy may alleviate hot flashes in menopause, large-scale study finds
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/27/2015)... 2015 CompanionDx announced that ... genomic analysis in personalized cancer therapy: Non-small cell lung ... Society of Clinical Oncology (ASCO) as part of their ... , The molecular and clinical data used for the ... database. The study reports improved patient outcomes from a ...
(Date:5/27/2015)... On June 5, Plan B [the ... with LifeSource to host Donate Your Break, a public ... a LifeSource donor coach outside of 116 W. Illinois ... Demand for whole blood units is highest for LifeSource, ... months. LifeSource requires approximately 1,000 donations per day to ...
(Date:5/27/2015)... This is a professional and ... Omega-3 industry. The report provides a basic overview ... industry chain structure. The Omega-3 market analysis is ... competitive landscape analysis, and key regions development status. ... Company, Seadragon Marine Oils, Norwegian Fish Oil, Croda ...
(Date:5/27/2015)... Meadows, IL (PRWEB) May 27, 2015 ... release of its SonarMD Platform, a first-of-its ... monitoring and managing patients with chronic gastrointestinal ... Kosinski, MD, MBA, the application allows physicians ... visits through the ongoing use of electronic ...
(Date:5/27/2015)... “Heroin has never been more plentiful or ... coming from,” says Harford County Sheriff Jeff Gahler, as quoted ... the surging heroin related incidents in Baltimore, police resources are ... prevent heroin addiction and subsequent abuse before it turns into ... Baltimore is a drug and alcohol rehab facility specializing in ...
Breaking Medicine News(10 mins):Health News:CompanionDx® Analyzes Non-small Cell Lung Cancer Data for Personalized Cancer Therapy 2Health News:CompanionDx® Analyzes Non-small Cell Lung Cancer Data for Personalized Cancer Therapy 3Health News:Donate Your Break and Save Lives at the River North Blood Drive 2Health News:Omega-3 Market: Global 2015 Analysis & 2020 Forecasts on Market Size 2Health News:SonarMD™, LLC, Launches Game-Changing, IBD Population Health Management Platform 2Health News:The Price of Heroin in Baltimore Drops, Surging Use and Causing Rife Overdose Deaths 2Health News:The Price of Heroin in Baltimore Drops, Surging Use and Causing Rife Overdose Deaths 3
... Service Provider Chooses SonicWALL to Satisfy Business Need ... SonicWALL, Inc. (Nasdaq: SNWL ... announced that ZirMed, Inc., a leader in revenue ... Louisville, Kentucky, has implemented a SonicWALL(R) E-Class NSA ...
... Clarient, Inc. (Nasdaq: CLRT ... resource for pathologists, oncologists and the pharmaceutical industry, today ... renewed, expanded and extended its senior subordinated revolving credit ... SFE ), Clarient,s majority shareholder."In the current market ...
... medical equipment supplier, now sells its DRE Integra AV-S with a ventilator ... patients attempt to breathe spontaneously. , ... (Vocus) March 3, 2009 -- ... by Business First of Louisville, continues expanding its DRE Integra AV-S ...
... releases the first in a series of residential vacuum cleaner reviews ... , ... Boise, Idaho (Vocus) March 3, 2009 -- Before spending hundreds of ... the market, savvy shoppers turn to the Internet to research their choices. ...
... incidence of obesity-induced type 2 diabetes mellitus continues to ... obesity can completely eliminate all manifestations of diabetes. In ... The American Journal of Medicine , investigators analyzed ... showed that 78.1% of diabetic patients had complete resolution ...
... that helps trigger autoimmunity could lead to new treatments ... kill thousands of children annually, according to researchers. , ... has discovered genetic evidence that two distinct molecular ... a vitally important cell type in limiting undesirable immune ...
Cached Medicine News:Health News:SonicWALL Delivers Flexible High-Performance Threat Management for ZirMed 2Health News:SonicWALL Delivers Flexible High-Performance Threat Management for ZirMed 3Health News:Clarient Renews and Expands Mezzanine Credit Facility With Safeguard 2Health News:Clarient Renews and Expands Mezzanine Credit Facility With Safeguard 3Health News:Clarient Renews and Expands Mezzanine Credit Facility With Safeguard 4Health News:DRE AV-S Ventilator Now Has Multiple Spontaneous Breathing Modes 2Health News:DRE AV-S Ventilator Now Has Multiple Spontaneous Breathing Modes 3Health News:DRE AV-S Ventilator Now Has Multiple Spontaneous Breathing Modes 4Health News:Shopping for a Vacuum Cleaner? Know What You're Buying! Internet Site and Rating System Can Help 2Health News:Shopping for a Vacuum Cleaner? Know What You're Buying! Internet Site and Rating System Can Help 3Health News:Study shows potential for resolving type 2 diabetes with bariatric surgery 2Health News:Genetic evidence points to potential therapeutic bypass for autoimmune process 2Health News:Genetic evidence points to potential therapeutic bypass for autoimmune process 3
(Date:5/27/2015)... 2015  Cambrex Corporation (NYSE: CBM, "Cambrex") is pleased to ... Chief Financial Officer, will present at the Jefferies 2015 Global ... in New York City . ... from the Cambrex website at www.cambrex.com in the ... be available for 90 days after the live event concludes.  ...
(Date:5/27/2015)... , May 27, 2015  Novartis will highlight ... 21 medicines and 11 investigational compounds across more ... Society of Clinical Oncology (ASCO) Annual Meeting, May ... Hematology Association (EHA), June 11-14. Data will demonstrate ... types, including melanoma, lung, breast, kidney and blood ...
(Date:5/27/2015)... , May 25, 2015 Research and Markets ... the "Research and Future Development Trend Forecast of ... At present, there are 35,600 dialysis centers ... ratio are large due to the different regional operating ... centers in other Asian countries are operated by state-owned ...
Breaking Medicine Technology:Novartis presents new data on 21 medicines and 11 investigational compounds at ASCO and EHA 2Novartis presents new data on 21 medicines and 11 investigational compounds at ASCO and EHA 3Novartis presents new data on 21 medicines and 11 investigational compounds at ASCO and EHA 4Novartis presents new data on 21 medicines and 11 investigational compounds at ASCO and EHA 5Novartis presents new data on 21 medicines and 11 investigational compounds at ASCO and EHA 6Novartis presents new data on 21 medicines and 11 investigational compounds at ASCO and EHA 7Novartis presents new data on 21 medicines and 11 investigational compounds at ASCO and EHA 8China Dialysis Market Report: Research and Future Development Trends and Forecasts 2015-2020 2
... and BRUSSELS, June 30, 2011 UCB and Harvard ... signing ceremony that took place in Boston last night ... of Belgium. (Photo: http://photos.prnewswire.com/prnh/20110630/NY28450 ) ... bridge between industry and academia, with Harvard scientists continuing ...
... 2011 Company remains committed to speeding ... R&D pipeline boasts 70 potential medicines in clinical development, including 33 ... least ten potential new medicines in Phase III by the end ... areas such as neuroscience, diabetes and oncology, as well as new ...
Cached Medicine Technology:UCB Launches Research Alliance with Harvard University 2UCB Launches Research Alliance with Harvard University 3Lilly Outlines For Investors How Its Innovation-Based Strategy and Robust Pipeline Will Drive Future Growth Following Upcoming Patent Expirations 2Lilly Outlines For Investors How Its Innovation-Based Strategy and Robust Pipeline Will Drive Future Growth Following Upcoming Patent Expirations 3Lilly Outlines For Investors How Its Innovation-Based Strategy and Robust Pipeline Will Drive Future Growth Following Upcoming Patent Expirations 4Lilly Outlines For Investors How Its Innovation-Based Strategy and Robust Pipeline Will Drive Future Growth Following Upcoming Patent Expirations 5Lilly Outlines For Investors How Its Innovation-Based Strategy and Robust Pipeline Will Drive Future Growth Following Upcoming Patent Expirations 6Lilly Outlines For Investors How Its Innovation-Based Strategy and Robust Pipeline Will Drive Future Growth Following Upcoming Patent Expirations 7Lilly Outlines For Investors How Its Innovation-Based Strategy and Robust Pipeline Will Drive Future Growth Following Upcoming Patent Expirations 8Lilly Outlines For Investors How Its Innovation-Based Strategy and Robust Pipeline Will Drive Future Growth Following Upcoming Patent Expirations 9Lilly Outlines For Investors How Its Innovation-Based Strategy and Robust Pipeline Will Drive Future Growth Following Upcoming Patent Expirations 10Lilly Outlines For Investors How Its Innovation-Based Strategy and Robust Pipeline Will Drive Future Growth Following Upcoming Patent Expirations 11Lilly Outlines For Investors How Its Innovation-Based Strategy and Robust Pipeline Will Drive Future Growth Following Upcoming Patent Expirations 12Lilly Outlines For Investors How Its Innovation-Based Strategy and Robust Pipeline Will Drive Future Growth Following Upcoming Patent Expirations 13Lilly Outlines For Investors How Its Innovation-Based Strategy and Robust Pipeline Will Drive Future Growth Following Upcoming Patent Expirations 14Lilly Outlines For Investors How Its Innovation-Based Strategy and Robust Pipeline Will Drive Future Growth Following Upcoming Patent Expirations 15Lilly Outlines For Investors How Its Innovation-Based Strategy and Robust Pipeline Will Drive Future Growth Following Upcoming Patent Expirations 16
... BVM 6500 enables physicians ... determine UEBW (ultrasound estimated ... volume using 3-dimensional V-mode ... was designed to assist ...
... Bard Collagen Implant, the world's leading bulking ... for the treatment of Stress Urinary Incontinence ... surrounding urethral tissue to aid coaptation in ... body's own structure, Contigen Bard Collagen Implant ...
... The Titan™ Inflatable Penile Prosthesis ... designed to be surgically implanted ... management of erectile dysfunction (also ... provides the patient with voluntary ...
... The AMS 650™ and 600M™ malleable ... many patientsespecially those with limited dexterity. These ... allows the patient to position them in ... make the penis rigid enough for sexual ...
Medicine Products: