Navigation Links
Study tracks leukemia's genetic evolution, may help predict disease course, tailor care
Date:2/14/2013

BOSTON AND CAMBRIDGE, Mass.Tumors are not factories for the mass production of identical cancer cells, but are, in reality, patchworks of cells with different patterns of gene mutations. In a new study, researchers at Dana-Farber Cancer Institute and the Broad Institute show, more fully than ever before, how these mutations shift and evolve over time in chronic lymphocytic leukemia (CLL) providing a strobe-like look at the genetic past, present, and future of CLL tumors.

Their report, which will be published online today by the journal Cell, suggests that evolution holds the key to understanding why CLL often recurs after treatment, and to the development of better therapies. The study helps explain why patients with a seemingly similar disease often don't derive the same benefit from therapy, why CLL recurs faster in some patients than others, and why therapy itself may speed the recurrence of the disease.

"One of the biggest challenges that patients with CLL and their physicians face is how to deal with relapse," said study co-senior author, Catherine Wu, MD, of Dana-Farber. "It's been clear for some time that tumors are collections of different subgroups of cells, each with a particular set of gene mutations, and that, over time, some of these subgroups become more prevalent and some less. So the tumor that you initially treat can be quite different, from a genetic standpoint, from the tumor that recurs later on."

For this study, Wu and her colleagues used next-generation gene-sequencing technology to chart changes in close to 100 samples of CLL tissue. "From there," Wu explained, "we began exploring how these different subgroups of cells influence the effectiveness of therapy. What can these subgroups tell us about how the cancer originated and developed, and how and how long it will respond to treatment before relapsing?"

Co-senior author Gad Getz, PhD, of the Broad Institute and Massachusetts General Hospital, a
'/>"/>

Contact: Teresa Herbert
teresa_herbert@dfci.harvard.edu
617-632-5653
Dana-Farber Cancer Institute
Source:Eurekalert  

Page: 1 2 3 4

Related medicine news :

1. Study: Behavioral therapy for children with autism can impact brain function
2. Obesity coverage in black newspapers is mostly negative, MU study finds
3. ACP launches study of cloud-based quality improvement program on diabetes and CVD care
4. Our primitive reflexes may be more sophisticated than they appear, study shows
5. Study suggests link between untreated depression and response to shingles vaccine
6. Queens study aims to use stem cells to help save sight of diabetes sufferers
7. Californias Tobacco Control Program generates huge health care savings, UCSF study shows
8. Vanderbilt study reveals clues to childhood respiratory virus
9. Outdoor Fast-Food Ads Linked to Obesity, Study Suggests
10. Key molecule suppresses growth of cancerous liver tumors, Mayo study finds
11. Cyberbullying as Harmful as Physical Threats, Study Finds
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Study tracks leukemia's genetic evolution, may help predict disease course, tailor care
(Date:8/30/2014)... Hundreds of Byetta lawsuits ( http://www.byettalawsuit.com ... forward in U.S. courts, Bernstein Liebhard LLP reports. According ... 31, 2014, Byetta and Bydureon (an extended-release version of ... that allege the drugs caused pancreatitis, pancreatic cancer and ... claims are pending in a multidistrict litigation underway in ...
(Date:8/30/2014)... 30, 2014 In today’s world, a good ... get. Snoring and sleep apnea (a medical problem where the ... their bed partners of the rest they need to face ... population snores and 20 million people in the United States ... diagnosed and treated; and of those treated, many cannot tolerate ...
(Date:8/30/2014)... Market Research Report on Global ... professional and in-depth market survey on Global and ... the basic information of Lab Oven including its ... explores global and China’s top manufacturers of Lab ... and market share etc. , The report further ...
(Date:8/30/2014)... 30, 2014 The federal judge ... ( http://www.injurybeacon.com/transvaginal-mesh/ ) filed against Boston Scientific Corp. ... cases selected for one of the proceeding’s bellwether ... 18, 2014, U.S. District Judge Joseph R. Goodwin ... with Boston Scientific’s contention that a consolidated trial ...
(Date:8/30/2014)... 2014 In today’s world, a good ... to get. Snoring and sleep apnea (a medical problem ... robs people and their bed partners of the rest ... 45% of the population snores and 20 million people ... these, only 10% have been diagnosed and treated; and ...
Breaking Medicine News(10 mins):Health News:Byetta Lawsuits Move Forward, as Bernstein Liebhard LLP Notes Settlements in More than 80 Cases 2Health News:Byetta Lawsuits Move Forward, as Bernstein Liebhard LLP Notes Settlements in More than 80 Cases 3Health News:Snoring: Bad for Relationships, Bad for Health 2Health News:Snoring: Bad for Relationships, Bad for Health 3Health News:Lab Oven Industry for Global and Chinese Market Forecasts to 2019 in New Research Report Available at ReportsnReports.com 2Health News:Lab Oven Industry for Global and Chinese Market Forecasts to 2019 in New Research Report Available at ReportsnReports.com 3Health News:Lab Oven Industry for Global and Chinese Market Forecasts to 2019 in New Research Report Available at ReportsnReports.com 4Health News:Transvaginal Mesh Lawsuit News: Federal Judge Refuses Boston Scientific Request for Separate Trials in Four Bellwether Cases, Bernstein Liebhard LLP Reports 2Health News:Transvaginal Mesh Lawsuit News: Federal Judge Refuses Boston Scientific Request for Separate Trials in Four Bellwether Cases, Bernstein Liebhard LLP Reports 3Health News:Snoring: Bad for Relationships, Bad for Health 2Health News:Snoring: Bad for Relationships, Bad for Health 3
... at the Kimmel Cancer Center at Thomas Jefferson ... how common blood pressure medications might help prevent ... in the laboratory that one type of pressure-lowering ... cancer cell growth and causes cell death. , ...
... Researchers at St. Jude Childrens Research Hospital have discovered ... to initiate most cases of an aggressive and often-fatal ... known as "cooperating oncogenic lesions," include the deletion of ... the development of a blood stem cell into a ...
... Now Available in ... Commercial Fitness Equipment, LAKE SUCCESS, ... monitoring and fitness assessment technology, announced today,that its patented OwnCode(R) ... can now be seamlessly and cost-effectively,incorporated into commercial fitness equipment, ...
... WESTLAKE VILLAGE, Calif., April 14 ... has been recognized for,call center operation ... Power,and Associates Certified Call Center Program(SM). ... the HealthFusion call center,operations to provide ...
... Prix Galien USA 2008 Announced for September 24, ... Nobel Laureate Walter,Gilbert, Ph.D., the Carl M. ... of Biogen, has joined fellow Nobel Laureates on ... in,biopharmaceutical research. Prix Galien USA 2008,( http://www.prix-galien-usa.com ) ...
... April 14 It,s 2 a.m. on a Sunday morning, your,dog ... weekend. What do,you do?, Well, this scenario happened to pet ... Internet about what to do for his lab mix,he realized he ... He,needed to develop a comprehensive resource for pet owners everywhere to,assist ...
Cached Medicine News:Health News:Blood pressure drugs halt pancreatic cancer cell growth, Jefferson researchers find 2Health News:St. Jude discovery offers new avenues to understanding an aggressive form of leukemia 2Health News:St. Jude discovery offers new avenues to understanding an aggressive form of leukemia 3Health News:Polar Introduces Cost-Effective Solution to Reduce Heart Rate Data Cross-Talk 2Health News:J.D. Power and Associates Reports: HealthFusion Recognized for Providing an Outstanding Customer Service Experience 2Health News:J.D. Power and Associates Reports: HealthFusion Recognized for Providing an Outstanding Customer Service Experience 3Health News:Prix Galien USA Welcomes Eighth Nobel Laureate to its Prestigious Award Committee 2Health News:Prix Galien USA Welcomes Eighth Nobel Laureate to its Prestigious Award Committee 3Health News:Comprehensive Pet Care Web Site Takes New Approach in Helping Pet Owners With Their Furry Members of the Family 2
(Date:8/29/2014)... 2014  Pacific Medical Data Solutions is excited to ... . The main website, along with the site,s blog, ... services and content relevant to the medical billing industry. ... viewers can now better understand how PMDS products help ... create a more visible platform about medical billing best ...
(Date:8/29/2014)... , August 29, 2014 ... and collaboration software has announced a major new deal ... founded by renowned pathology expert, Dr. Marius Nap ... of the 26th European Congress of Pathology which is ... the ExCeL Arena, London where ...
(Date:8/29/2014)... AMSTERDAM , August 29, 2014 ... invited to participate in the inaugural Tweetchat taking ... CPhI Worldwide , organised by UBM ... October 2014. #CPhIChat is a first of its ... media working across the supply chain, aimed to ...
Breaking Medicine Technology:PMDS Announces New Website 2Pixcelldata Announces New Deal with Dutch Tele-Pathology Specialists eX-Path Ahead of ECP 2014 2CPhI Worldwide to Host #CPhIChat Provoking Debate on the Future of Pharma 2CPhI Worldwide to Host #CPhIChat Provoking Debate on the Future of Pharma 3
... 21, 2011 Express Scripts, Inc. (NASDAQ: ESRX ... ) today announced that they have entered into a definitive ... per share in cash and stock, or $29.1 billion, based ... cash and 0.81 shares for each Medco share they own ...
... AstraZeneca (NYSE: AZN ) announced today ... approved BRILINTA™ (ticagrelor) tablets to reduce the rate of ... in adult patients with acute coronary syndrome (ACS), compared ... assets associated with this release, please click: http://multivu.prnewswire.com/mnr/astrazeneca/50355/ ...
Cached Medicine Technology:Express Scripts and Medco Health Solutions Sign Definitive Merger Agreement; Medco Shareholders to Receive $29.1 Billion 2Express Scripts and Medco Health Solutions Sign Definitive Merger Agreement; Medco Shareholders to Receive $29.1 Billion 3Express Scripts and Medco Health Solutions Sign Definitive Merger Agreement; Medco Shareholders to Receive $29.1 Billion 4Express Scripts and Medco Health Solutions Sign Definitive Merger Agreement; Medco Shareholders to Receive $29.1 Billion 5Express Scripts and Medco Health Solutions Sign Definitive Merger Agreement; Medco Shareholders to Receive $29.1 Billion 6Express Scripts and Medco Health Solutions Sign Definitive Merger Agreement; Medco Shareholders to Receive $29.1 Billion 7Express Scripts and Medco Health Solutions Sign Definitive Merger Agreement; Medco Shareholders to Receive $29.1 Billion 8Express Scripts and Medco Health Solutions Sign Definitive Merger Agreement; Medco Shareholders to Receive $29.1 Billion 9Express Scripts and Medco Health Solutions Sign Definitive Merger Agreement; Medco Shareholders to Receive $29.1 Billion 10Express Scripts and Medco Health Solutions Sign Definitive Merger Agreement; Medco Shareholders to Receive $29.1 Billion 11Express Scripts and Medco Health Solutions Sign Definitive Merger Agreement; Medco Shareholders to Receive $29.1 Billion 12Express Scripts and Medco Health Solutions Sign Definitive Merger Agreement; Medco Shareholders to Receive $29.1 Billion 13Express Scripts and Medco Health Solutions Sign Definitive Merger Agreement; Medco Shareholders to Receive $29.1 Billion 14FDA Approves New Medicine BRILINTA™ (Ticagrelor) for Use in the US 2FDA Approves New Medicine BRILINTA™ (Ticagrelor) for Use in the US 3FDA Approves New Medicine BRILINTA™ (Ticagrelor) for Use in the US 4FDA Approves New Medicine BRILINTA™ (Ticagrelor) for Use in the US 5FDA Approves New Medicine BRILINTA™ (Ticagrelor) for Use in the US 6FDA Approves New Medicine BRILINTA™ (Ticagrelor) for Use in the US 7
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
Medicine Products: