Navigation Links
Study to examine new treatment for West Nile virus
Date:8/18/2010

(CHICAGO) Neurological and infectious disease experts at Rush University Medical Center are testing a new drug therapy for the treatment of individuals with West Nile fever or suspected central nervous system infection due to the West Nile virus. Rush is the only site in the Midwest enrolling patients into the $50 million dollar, NIH-funded, Phase II clinical trial called PARADIGM.

The new drug treatment for West Nile virus that is being tested, also known as MGAWN1, is a humanized monoclonal antibody, which is a drug engineered to help the body seek and destroy the virus. During the randomized, double-blind study, patients with the signs and symptoms of West Nile virus will receive either a single infusion of MGAWN1 or a placebo.

"Currently, there are no approved treatments for people with severe West Nile virus infection and there is no standard of care that is highly effective against it," said Dr. Russell Bartt, neurologist and lead site investigator of the study at Rush. "Patients with the disease are hospitalized and receive supportive care."

"This new drug therapy has the potential of neutralizing the virus and could possibly reduce or prevent complications associated with the West Nile neuroinvasive disease," said Bartt. "This could represent a significant advancement for patients with West Nile."

The monoclonal antibody latches on to the West Nile virus in order for the body's immune system to recognize and eliminate it. The treatment will hopefully reduce the severity and also shorten the length of the disease.

The PARADIGM study will be testing the safety and tolerability of the drug therapy in infected patients. The first phase of the study of MGAWN1 tested doses in healthy adults and demonstrated adequate safety and was tolerated well.

West Nile virus is a disease transmitted through the bite of an infected mosquito. When someone is bitten by an infected mosquito, the virus can enter the blood stream and circulate. . The virus may be eliminated, but in some cases, it may end up in the tissues in the body, lymph nodes, as well as invade neurological tissues where the virus replicates and may cause symptoms in days and weeks.

Since 1999, there have been more than 29,000 cases of confirmed West Nile virus infection in the U.S. About 20 percent of humans infected with the West Nile virus experience West Nile fever with symptoms that include fever, headache, body aches, stiff neck, muscle weakness, confusion, skin rash, and swollen lymph glands.

In about one percent of human infections, West Nile virus enters the brain and spinal cord causing severe, life-threatening neuroinvasive disease. In these types of serious cases, West Nile virus can cause encephalitis (inflammation of the brain), meningitis (inflammation of the coverings in the brain and spinal cord), or acute flaccid paralysis.


'/>"/>

Contact: Deb Song
deb_song@rush.edu
312-942-0588
Rush University Medical Center
Source:Eurekalert

Related medicine news :

1. When Doctors Admit Mistakes, Fewer Malpractice Suits Result, Study Says
2. MRSA policies differ among hospitals, study shows
3. Study examines risks, rewards of energy drinks
4. Berkeley study shows ozone and nicotine a bad combination for asthma
5. Henry Ford Hospital study: Donor Risk Index does not impact outcomes on a small scale
6. In NIH-funded study, researchers uncover step in brain events leading up to addiction
7. Lithium of No Benefit in ALS, Study Finds
8. Study shows behaviors and attitudes towards oral sex are changing
9. Study Offers Support for Surgery After Compression Fracture
10. More Medicaid Patients Using ERs, Study Finds
11. Study shows physicians reluctant to use chemoprevention for prostate cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/25/2016)... (PRWEB) , ... June 25, 2016 , ... Conventional wisdom ... of success. In terms of the latter, setting the bar too high can result ... more than just slow progress toward their goal. , Research from PsychTests.com ...
(Date:6/24/2016)... CA (PRWEB) , ... June 24, 2016 , ... Marcy was in a crisis. Her ... would lash out at his family verbally and physically. , “When something upset him, he ... he would use it. He would throw rocks at my other children and say he ...
(Date:6/24/2016)... ... June 24, 2016 , ... Comfort Keepers® of San Diego, ... and the Road To Recovery® program to drive cancer patients to and from their ... to ensure the highest quality of life and ongoing independence. Getting to and ...
(Date:6/24/2016)... , ... June 24, 2016 , ... ... is proud to recognize Dr. Barry M. Weintraub as a prominent plastic surgeon ... beautiful women in the world, and the most handsome men, look naturally attractive. ...
(Date:6/24/2016)... ... ... Venture Construction Group (VCG) sponsors Luke’s Wings 5th ... Woodmont Country Club at 1201 Rockville Pike, Rockville, Maryland, 20852. The event raised ... have been wounded in battle and their families. Venture Construction Group is a 2016 ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)...  Arkis BioSciences, a leading innovator in the ... cerebrospinal fluid treatments, today announced it has secured ... led by Innova Memphis, followed by Angel Capital ... Arkis, new financing will accelerate the commercialization of ... of its in-licensed Endexo® technology. ...
(Date:6/23/2016)... , June 23, 2016 Any dentist who ... challenges of the current process. Many of them do not ... the technical difficulties and high laboratory costs involved. And those ... offer it at such a high cost that the majority ... Dr. Parsa Zadeh , founder of Dental ...
(Date:6/23/2016)... Roche (SIX: RO, ROG; OTCQX: RHHBY) announced ... BRAHMS PCT (procalcitonin) assay as a dedicated testing solution ... this clearance, Roche is the first IVD company in ... sepsis risk assessment and management. PCT is ... levels in blood can aid clinicians in assessing the ...
Breaking Medicine Technology: