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Study targets treatment for serious ACE inhibitor side effect
Date:4/28/2011

DETROIT A new Henry Ford Hospital study takes a closer look at one of the lesser known, but potential most serious side-effects of ACE inhibitor use facial, tongue and airway swelling and identifies a successful and less invasive course of treatment.

Using a treatment protocol developed by Henry Ford, patients' symptoms were quickly diagnosed and promptly treated to reduce swelling, resulting in no tracheotomies to open the airway or reported deaths, says study author Samer Al-Khudari, M.D.

"This side-effect is rare, but when it happens, it can be anxiety-provoking for both patients and physicians," says Dr. Al-Khudari, a member of the Department of Otolaryngology-Head & Neck Surgery at Henry Ford.

"Our goal was to really take a closer look at the treatment options available and develop a better standard of care for not just otolaryngologist, but all health care providers to follow."

The study will presented April 30 at 114th Annual Meeting of the Triological Society, part of the Combined Otolaryngology Spring Meetings in Chicago.

ACE inhibitors are a popular class of drugs most often prescribed to treat high blood pressure, congestive heart failure and kidney disease, as well as prevent stroke.

While they are well-tolerated by most patients, there are some side effects including angiodema, swelling that occurs in areas of the head and neck (floor of mouth, tongue, lips, throat) and can lead to airway obstruction.

Patients most commonly come into the emergency department experiencing difficulty swallowing, shortness of breath and voice changes.

ACE inhibitor induced angiodema (AIIA) tends to be more common among African Americans.

The study included 40 patients who received care at Henry Ford Hospital over a one-year period. The majority of patients (92%) were African American, and most were taking an ACE inhibitor called Lisinopril.

Treatment for all patients
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Contact: Krista Hopson
khopson1@hfhs.org
313-874-7207
Henry Ford Health System
Source:Eurekalert

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