Navigation Links
Study targets key molecule to reverse kidney damage in mice
Date:3/7/2012

BOSTON -- In findings that may lead to clinical trials of a promising new drug for kidney disease, researchers at Beth Israel Deaconess Medical Center (BIDMC) and their colleagues have identified a key molecular player and shown how a targeted experimental drug can reverse kidney damage in mouse models of diabetes, high blood pressure, genetic kidney disease, and other kidney injuries.

The study builds on a discovery that, in mice, a key protein can repair and reverse renal fibrosis, the critical damage caused by different kidney diseases in humans. The new paper details 10 years of methodical follow-up experiments to understand, verify and harness the protective molecular process with a new drug that can be tested in people. The paper appears in the March 2012 issue of Nature Medicine.

"This paper reports the discovery of one of the first targeted drugs specifically developed to reverse fibrosis and regenerate the kidney," said senior author Raghu Kalluri, MD, PhD, Chief of the Division of Matrix Biology at BIDMC and Professor of Medicine at Harvard Medical School (HMS). "We're optimistic about the benefits, but the real proof will come from clinical testing."

Chronic kidney disease is becoming a major public health problem, partly due to the increase in obesity, diabetes, hypertension and an aging population. It affects one out of every 10 people older than 20, and is most prevalent in those over 60. Most people with impaired kidney function are in the early stages and have no symptoms, but deteriorating kidneys significantly raise the risk of death by cardiovascular disease. Those who survive heart attacks and strokes can progress to end-stage renal disease, which requires dialysis in most cases or transplants when donor kidneys are available.

"The field is desperate for new interventions that can halt or slow the progression of renal failure," said nephrologist Qais Al-Awqati, MB, ChB, a professor of medicine and
'/>"/>

Contact: Bonnie Prescott
bprescot@bidmc.harvard.edu
617-667-7306
Beth Israel Deaconess Medical Center
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Despite Treatment, Employees with Depression Generate Higher Absentee Costs, According to Thomson Reuters Study
2. American Council on Exercise (ACE) Study Reveals Kettlebells Provide Powerful Workout in Short Amount of Time
3. TV drama can be more persuasive than news program, study finds
4. Study carried out into biological risks of eating reptiles
5. Neuroimaging study may pave way for effective Alzheimers treatments
6. Study finds racial gaps continue in heart disease awareness
7. Luth Researchs IndicatorEDG(TM) Study Finds Americans Hopes of Achieving Their Dreams Are Fading
8. First blinded study of venous insufficiency prevalence in MS shows promising results
9. Soothing infants with food focus of childhood obesity study
10. People with anxiety disorder less able to regulate response to negative emotions, study shows
11. American Heart Association Rapid Access Journal Report: Study Finds Racial Gaps Continue in Heart Disease Awareness, Low Knowledge of Heart Attack Warning Signs Among Women
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/23/2014)... 23, 2014 Mel Frank, also known ... growing and harvesting marijuana. He is perhaps one of ... and he’ll be leading a special elective course on ... 5:00 pm at Oaksterdam University in Oakland, ... and nomenclature, harvesting and manicuring, and identifying preflowers and ...
(Date:9/23/2014)... 23, 2014 "The primary purpose of the ... an inventor from Sacramento, Ca.. "Call lights are often found ... hanging on the IV pole out of the patient's reach. ... call device whenever they need it, I created this caddy." ... the nurse call device within easy reach. The accessory ensures ...
(Date:9/23/2014)... World of Home Fitness is committed to supporting ... gym has been raising money to support Meals on ... World of Home Fitness has participated in and raised ... summer, World of Home Fitness raised more than $600 ... participants helped feed seniors "one rep at a time." ...
(Date:9/23/2014)... Dr. Connie Casad has announced that she will be relocating ... 12200 Park Central Drive, Suite 200, Dallas, Texas 75251 on ... Aesthetics, Optimal Health and Wellness, her gynecology practice and concierge ... said, “The patients’ comfort and satisfaction are our primary goal. ... always feel like their needs are valued and recognized by ...
(Date:9/23/2014)... -- Both drinking and getting drunk at an early ... high school students, a new study suggests. The ... who drink, could help expand alcohol-prevention efforts aimed at ... them from becoming binge drinkers, the researchers suggested. , ... use and progression to first heavy use as risk ...
Breaking Medicine News(10 mins):Health News:Special Elective Course Added to Oaksterdam University Schedule; Unique Opportunity to Learn From the “Godfather of Cannabis” Mel Frank on September 27, 2014 2Health News:World of Home Fitness Supports Meals on Wheels 2Health News:Dr. Connie Casad Moving to New Office Location 2Health News:Younger Age at First Drink, Higher Odds for Problem Drinking: Study 2Health News:Younger Age at First Drink, Higher Odds for Problem Drinking: Study 3
... Movie Awards, Opportunity to Participate in Trip to Africa with UN Foundation,s Nothing ... ... Foundation is partnering with MTV to give fans of the MTV hit ... Awards or a trip to Africa with the UN Foundation,s Nothing But Nets ...
... may benefit from the discovery of a small but ... could potentially be reversed relatively easily, preventing cancer-promoting genes ... at Children,s Hospital Boston and the Dana-Farber Cancer Institute, ... of Cancer Cell . , While cure rates ...
... On Friday, November 21, 2008, at,Gotham Hall ... and socialite Roberta Armani, host the 2nd annual ... while Olympic,Gold Medalist Michael Phelps, Poker Pro Lee ... Bailey "Cash Cab," Ana Ortiz "Ugly,Betty," Mark Indelico ...
... down gene expression driving some leukemias , ... (PRWEB) ... from the discovery of a small but potent epigenetic change that ... preventing cancer-promoting genes from being turned on. The study, led by ...
... CT (MDCT) scans are highly accurate in detecting airway ... Beth Israel Deaconess Medical Center and Harvard Medical School ... (97%) of 30 complications in 21 patients, including all ... tracheal perforation; MDCT also identified three of four cases ...
... manufacturers better optimize and secure ... N.J., Nov. 3 Drawing on its deep ... of Packaging Execution Systems (PES), today announced that ... Pack Expo 2008. The,company has a strong worldwide ...
Cached Medicine News:Health News:Sweepstakes Offers Viewers Chance to Win 'Your Turn to Get Exiled' Experience 2Health News:Sweepstakes Offers Viewers Chance to Win 'Your Turn to Get Exiled' Experience 3Health News:Sweepstakes Offers Viewers Chance to Win 'Your Turn to Get Exiled' Experience 4Health News:Tackling a hard-to-treat childhood cancer by targeting epigenetic changes 2Health News:Supermodel Helena Houdova & Roberta Armani Host 2nd Annual Sunflower Children Poker Benefit 2Health News:Tackling Hard-to-treat Childhood Cancer by Targeting Epigenetic Changes 2Health News:Tackling Hard-to-treat Childhood Cancer by Targeting Epigenetic Changes 3Health News:Systech Unveils Complete Packaging Execution System at Pack Expo 2008 2
(Date:9/23/2014)... 2014 Research and ... of the  "Large Volume Wearable Injectors - ... ,     (Logo: http://photos.prnewswire.com/prnh/20130307/600769) ... significant potential for the future. From the ... to the modern-day pre-filled syringes, pen-injectors, needle ...
(Date:9/23/2014)... Rising health concerns, growing ... number of foreign and domestic players in the market ... India   The India Probiotic ... growth potential markets worldwide due to multiple factors such ... youth, changing food consumption patterns, increasing diabetic population, growing ...
(Date:9/23/2014)... , Sept 23, 2014  Vesselon, Inc. today announced ... of Directors, effective September 15, 2014. Dr. Raths, appointment ... its placement agent to market a private preferred Series ... early stroke treatment. "Jurgen,s deep experience across ... a great asset to Vesselon as we develop our ...
Breaking Medicine Technology:Large Volume Wearable Injectors - 2nd Edition 2Large Volume Wearable Injectors - 2nd Edition 3Large Volume Wearable Injectors - 2nd Edition 4Large Volume Wearable Injectors - 2nd Edition 5India Probiotic Market Pegged to Grow at Around 20% by 2019, Says TechSci Research 2India Probiotic Market Pegged to Grow at Around 20% by 2019, Says TechSci Research 3Vesselon Announces Jurgen Raths, MD to Serve on Board of Directors 2Vesselon Announces Jurgen Raths, MD to Serve on Board of Directors 3
... In conjunction with its third quarter 2011 earnings release (expected to ... (NYSE: CVD ) is pleased to invite you to ... live over the Internet on Thursday, November 3, 2011 at 9:00 ... and Slide Presentation When: Thursday, November 3, 2011, 9:00 ...
... YORK, Oct. 5, 2011 More than 40 million ... "age gracefully at home" due to the benefits of ... Virtual Health is a service provider that delivers a ... going beyond healthcare to also include meals, transportation, and ...
Cached Medicine Technology:A New Model of Healthcare is Unveiled, Offering Seniors Control, Independence and Dignity as They Age 2A New Model of Healthcare is Unveiled, Offering Seniors Control, Independence and Dignity as They Age 3
Economy Apron, Excellent Protection, Value Priced...
Pregnancy Apron...
All Day Comfort for the Lower Body...
Weight adjuster flexible back, comfortably places more weight on hips, less weight on shoulders....
Medicine Products: