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Study supports safety of antimicrobial peptide-coated contact lenses
Date:4/24/2014

olunteers wore melimine-coated or conventional contact lenses for one day. The coated and uncoated lenses had similar characteristics, including wettability, surface deposits, lens fitting on the center of the eye, lens movement and tightness, and coverage of the cornea. Importantly, there were no differences in redness of the eyean early sign of irritation or inflammation.

No Signs of Safety Problems with Melimine-Coated Lenses in Human Eye

The only significant difference was increased staining of the cornea (the clear outer layer of the eye) caused by melimine-coated lenses. Comfort ratings were similar between the two lensesjust one volunteer reported discomfort with the coated lenses.

No delayed reactions occurred after wearing melimine-coated lenses. The day after they were worn, the lenses were still active against Pseudomonas and Staphylococcus bacteria in culture.

Wearing contaminated contact lenses can cause redness and inflammation of the eye, leading to rare but potentially serious infections. "A contact lens with high antimicrobial activity may inhibit microbial adhesion and consequently reduce theseadverse events," Dr Dutta and coauthors write. Preliminary studies in animals have supported further research and development of contact lenses coated with melimine.

The new results add to previous data on the safety of melimine-coated lenses in animals, and provide initial evidence of their safety and comfort in humans. The lenses also show lasting antimicrobial activity. Dr Dutta and colleagues add, "Whether melimine could reduce contact lens-related adverse events during wear, especially extended wear, requires more clinical trials."

"Practitioners and researchers are hoping to develop new ways to try to reduce rare corneal infections associated with contact lens wear," comments Anthony Adams, OD, PhD, Editor-in-Chief of Optometry and Vision Science. He notes that the melimine-coated contact
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Contact: Connie Hughes
Connie.Hughes@wolterskluwer.com
646-674-6348
Wolters Kluwer Health
Source:Eurekalert

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