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Study suggests women have higher risk of hip implant failure
Date:2/18/2013

ments, the hazard ratios for women were 1.29 for all-cause revision, 1.32 for aseptic revision and 1.17 for septic revision, according to the study results.

"The role of sex in relationship to implant failure after total hip arthroplasty (THA) is important for patient management and device innovation," the study concludes. (JAMA Intern Med. Published online February 18, 2013. doi:10.1001/jamainternmed.2013.3271. Available pre-embargo to the media at http://media.jamanetwork.com.)

Editor's Note: This study was funded by a contract from the Division of Epidemiology, Office of Surveillance and Biometrics, Center for Devices and Radiological Health, U.S. Food and Drug Administration, Silver Spring, Md. Please see the article for additional information, including other authors, author contributions and affiliations, financial disclosures, funding and support, etc.

Commentary: Hip Implant Failure for Men, Women

In a related commentary, Diana Zuckerman, Ph.D., of the National Research Center for Women & Families, Washington, D.C., writes: "Sex-specific analyses are especially important in orthopedics because of substantial anatomical sex differences. These data of Inacio et al provide an important first step in understanding higher THA revision rates in women."

"Longer follow-up is necessary for hip implants, and the relatively small number of revisions and large number of potentially confounding variables in these short-term data make it challenging to use these data to help reduce the likelihood of revision surgery," Zuckerman continues.

"What is urgently needed is long-term comparative effectiveness research based on larger sample sizes, indicating which THA devices are less likely to fail in women and in men, with subgroup analyses based on age and other key patient traits, as well as key surgeon and hospital factors. Such data would enable p
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Contact: Catherine Hylas Saunders
csaunders@golinharris.com
703-622-4152
JAMA and Archives Journals
Source:Eurekalert

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