Navigation Links
Study suggests women have higher risk of hip implant failure
Date:2/18/2013

Women appear to have a higher risk of implant failure than men following total hip replacement after considering patient-, surgery-, surgeon-, volume- and implant-specific risk factors, according to a report published Online First by JAMA Internal Medicine, a JAMA Network publication.

Total hip replacement, also known as total hip arthroplasty (THA), is more often performed in women than men. Sex-specific risk factors and outcomes have been investigated in other major surgical procedures and, in theory, might be more important to study in THA because of anatomical differences between men and women, the authors write in the study background.

Maria C.S. Inacio, M.S., of the Southern California Permanente Medical Group, San Diego, and colleagues examined the association between sex and short-term risk of THA revision. A total of 35,140 THAs with three years of median follow-up were identified in a study population in which 57.5 percent of the patients were women and the average age of the patients was almost 66 years. The patients were enrolled in a total joint replacement registry from April 2001 through December 2010.

"In our analyses of a large THA cohort, including a diverse sample within 46 hospitals, we found that at the median follow-up of 3.0 years women have a higher risk of all-cause (HR [hazard ratio], 1.29) and aseptic (HR, 1.32) revision but not septic revision (HR, 1.17)," the authors comment.

A higher proportion of women received 28-mm femoral heads (28.2 percent vs. 13.1 percent) and had metal on highly cross-linked polyethylene-bearing surfaces (60.6 percent vs. 53.7 percent) than men. Men had a higher proportion of 36-mm or larger heads (55.4 percent vs. 32.8 percent) and metal on metal-bearing surfaces (19.4 percent vs. 9.6 percent). At five-year follow-up, implant survival was 97.4 percent. Device survival for men (97.7 percent) vs. woman (97.1 percent) was significantly different. After adjustments, the hazard ratios for women were 1.29 for all-cause revision, 1.32 for aseptic revision and 1.17 for septic revision, according to the study results.

"The role of sex in relationship to implant failure after total hip arthroplasty (THA) is important for patient management and device innovation," the study concludes. (JAMA Intern Med. Published online February 18, 2013. doi:10.1001/jamainternmed.2013.3271. Available pre-embargo to the media at http://media.jamanetwork.com.)

Editor's Note: This study was funded by a contract from the Division of Epidemiology, Office of Surveillance and Biometrics, Center for Devices and Radiological Health, U.S. Food and Drug Administration, Silver Spring, Md. Please see the article for additional information, including other authors, author contributions and affiliations, financial disclosures, funding and support, etc.

Commentary: Hip Implant Failure for Men, Women

In a related commentary, Diana Zuckerman, Ph.D., of the National Research Center for Women & Families, Washington, D.C., writes: "Sex-specific analyses are especially important in orthopedics because of substantial anatomical sex differences. These data of Inacio et al provide an important first step in understanding higher THA revision rates in women."

"Longer follow-up is necessary for hip implants, and the relatively small number of revisions and large number of potentially confounding variables in these short-term data make it challenging to use these data to help reduce the likelihood of revision surgery," Zuckerman continues.

"What is urgently needed is long-term comparative effectiveness research based on larger sample sizes, indicating which THA devices are less likely to fail in women and in men, with subgroup analyses based on age and other key patient traits, as well as key surgeon and hospital factors. Such data would enable patients and their physicians to choose the hip devices and surgical techniques that are most likely to be successful for a longer period," Zuckerman concludes.

(JAMA Intern Med. Published online February 18, 2013. doi:10.1001/jamainternmed.2013.19. Available pre-embargo to the media at http://media.jamanetwork.com.)

Editor's Note: Please see the article for additional information, including other authors, author contributions and affiliations, financial disclosures, funding and support, etc.


'/>"/>
Contact: Catherine Hylas Saunders
csaunders@golinharris.com
703-622-4152
JAMA and Archives Journals
Source:Eurekalert

Related medicine news :

1. Study suggests reduced lung function in infancy associated with wheeze later
2. Doctors fail to communicate impact of heart devices with patients, SLU study finds
3. U.S. Plans Billion-Dollar Project to Study the Brain
4. Women at Greater Risk for Hip Implant Failure, Study Finds
5. New study on Hepatitis C drug treatment in vivo and in vitro
6. Smoggy Air Tied to Heart Attacks: Study
7. Proscar Wont Boost Prostate Cancer Survival, Study Finds
8. Bel Marra Health Reports on a New Study: Body Image Influences Psychosocial Activities and Quality of Life.
9. New Study Finds Eating More Colorful Produce May Prevent or Delay ALS, Underscores Value of Health Enhancement Systems Program Design
10. MRSA Super Bug Prevalent in Nursing Homes, Study Finds
11. Study finds possible link between diabetes and increased risk of heart attack death
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/24/2017)... ... 24, 2017 , ... Houston dentist , Dr. Behzad ... Dental Center. Currently, patients can get single dental implants for $3,599 and All ... learn more about these offers by contacting Antoine Dental Center. Both of these ...
(Date:2/24/2017)... ... February 24, 2017 , ... Dr. Ronald ... officially announced the appointment of Peter A. Bell, DO, MBA, HPF, FACOEP-dist., FACEP, ... (LUCOM), beginning April 10. Dr. Bell comes to Liberty from the Ohio University ...
(Date:2/24/2017)... Texas (PRWEB) , ... February 24, 2017 , ... ... to The Medical Center at Craig Ranch building at 8080 State Highway 121, Suite ... Medical District with easy access to Highway 121. , As the practice has grown, ...
(Date:2/24/2017)... ... ... Yisrayl Hawkins, Pastor and Overseer at The House of Yahweh, has published a ... an astounding statement when he says that the entire Bible was written for the ... times so plainly that anyone should be able to see the time period. He ...
(Date:2/24/2017)... Lawn, NJ (PRWEB) , ... February 24, 2017 ... ... with robust marketing services, which specializes in thought leadership , media relations, ... marketing campaigns and services that will be powered through Act-On, an intuitive marketing ...
Breaking Medicine News(10 mins):
(Date:2/24/2017)... 24, 2017 Medical information groups within ... their self-service capabilities to manage inquiries from external ... New research from consulting leader Best Practices, ... self-service website portals where HCPs can sign on ... of many findings to emerge from the new ...
(Date:2/24/2017)... Februar 2017 ITL Limited, ( ASX: ... ist erfreut, für das zum 31. Dezember 2016 ... exzellente Ergebnisse vorlegen zu können. Eine vollständige Präsentation ... finden Sie hier . ... 2,12 Millionen USD (Dez. 2015: 1,04 Millionen USD; +104 %) ...
(Date:2/24/2017)... NEW YORK , Feb. 23, 2017 ... gives comprehensive insights on the various drugs ... The report covers all the drugs that ... Preclinical & Clinical). The pipeline focuses on ... small molecules, antibodies, stem cell therapies, recombinant ...
Breaking Medicine Technology: