Navigation Links
Study suggests women have higher risk of hip implant failure

Women appear to have a higher risk of implant failure than men following total hip replacement after considering patient-, surgery-, surgeon-, volume- and implant-specific risk factors, according to a report published Online First by JAMA Internal Medicine, a JAMA Network publication.

Total hip replacement, also known as total hip arthroplasty (THA), is more often performed in women than men. Sex-specific risk factors and outcomes have been investigated in other major surgical procedures and, in theory, might be more important to study in THA because of anatomical differences between men and women, the authors write in the study background.

Maria C.S. Inacio, M.S., of the Southern California Permanente Medical Group, San Diego, and colleagues examined the association between sex and short-term risk of THA revision. A total of 35,140 THAs with three years of median follow-up were identified in a study population in which 57.5 percent of the patients were women and the average age of the patients was almost 66 years. The patients were enrolled in a total joint replacement registry from April 2001 through December 2010.

"In our analyses of a large THA cohort, including a diverse sample within 46 hospitals, we found that at the median follow-up of 3.0 years women have a higher risk of all-cause (HR [hazard ratio], 1.29) and aseptic (HR, 1.32) revision but not septic revision (HR, 1.17)," the authors comment.

A higher proportion of women received 28-mm femoral heads (28.2 percent vs. 13.1 percent) and had metal on highly cross-linked polyethylene-bearing surfaces (60.6 percent vs. 53.7 percent) than men. Men had a higher proportion of 36-mm or larger heads (55.4 percent vs. 32.8 percent) and metal on metal-bearing surfaces (19.4 percent vs. 9.6 percent). At five-year follow-up, implant survival was 97.4 percent. Device survival for men (97.7 percent) vs. woman (97.1 percent) was significantly different. After adjustments, the hazard ratios for women were 1.29 for all-cause revision, 1.32 for aseptic revision and 1.17 for septic revision, according to the study results.

"The role of sex in relationship to implant failure after total hip arthroplasty (THA) is important for patient management and device innovation," the study concludes. (JAMA Intern Med. Published online February 18, 2013. doi:10.1001/jamainternmed.2013.3271. Available pre-embargo to the media at

Editor's Note: This study was funded by a contract from the Division of Epidemiology, Office of Surveillance and Biometrics, Center for Devices and Radiological Health, U.S. Food and Drug Administration, Silver Spring, Md. Please see the article for additional information, including other authors, author contributions and affiliations, financial disclosures, funding and support, etc.

Commentary: Hip Implant Failure for Men, Women

In a related commentary, Diana Zuckerman, Ph.D., of the National Research Center for Women & Families, Washington, D.C., writes: "Sex-specific analyses are especially important in orthopedics because of substantial anatomical sex differences. These data of Inacio et al provide an important first step in understanding higher THA revision rates in women."

"Longer follow-up is necessary for hip implants, and the relatively small number of revisions and large number of potentially confounding variables in these short-term data make it challenging to use these data to help reduce the likelihood of revision surgery," Zuckerman continues.

"What is urgently needed is long-term comparative effectiveness research based on larger sample sizes, indicating which THA devices are less likely to fail in women and in men, with subgroup analyses based on age and other key patient traits, as well as key surgeon and hospital factors. Such data would enable patients and their physicians to choose the hip devices and surgical techniques that are most likely to be successful for a longer period," Zuckerman concludes.

(JAMA Intern Med. Published online February 18, 2013. doi:10.1001/jamainternmed.2013.19. Available pre-embargo to the media at

Editor's Note: Please see the article for additional information, including other authors, author contributions and affiliations, financial disclosures, funding and support, etc.

Contact: Catherine Hylas Saunders
JAMA and Archives Journals

Related medicine news :

1. Study suggests reduced lung function in infancy associated with wheeze later
2. Doctors fail to communicate impact of heart devices with patients, SLU study finds
3. U.S. Plans Billion-Dollar Project to Study the Brain
4. Women at Greater Risk for Hip Implant Failure, Study Finds
5. New study on Hepatitis C drug treatment in vivo and in vitro
6. Smoggy Air Tied to Heart Attacks: Study
7. Proscar Wont Boost Prostate Cancer Survival, Study Finds
8. Bel Marra Health Reports on a New Study: Body Image Influences Psychosocial Activities and Quality of Life.
9. New Study Finds Eating More Colorful Produce May Prevent or Delay ALS, Underscores Value of Health Enhancement Systems Program Design
10. MRSA Super Bug Prevalent in Nursing Homes, Study Finds
11. Study finds possible link between diabetes and increased risk of heart attack death
Post Your Comments:
(Date:11/30/2015)... ... November 30, 2015 , ... In an effort to ... to access life-saving information provided directly from top experts in mesothelioma, in 2016 ... conferences in three major cities: Houston, San Francisco, and Chicago. , “For ...
(Date:11/30/2015)... Los Angeles, CA (PRWEB) , ... November 30, 2015 , ... ... hunger cravings that drive people to overeat are not necessarily caused by real hunger, ... brain that the stomach needs food. He notes that, while many patients are aware ...
(Date:11/30/2015)... FL (PRWEB) , ... November 30, 2015 , ... ... a comparison chart and ingredient list of its hemorrhoid ointment to its website. ... effective pain relief for people suffering from hemorrhoids. Adding the comparison chart and ...
(Date:11/30/2015)... ... November 30, 2015 , ... Using a combination of two blood sugar tests ... adults, according to a new study by researchers at the School of Public Health ... Adults: Using Combinations of Blood Glucose Tests ,” published in Frontiers in Public Health, ...
(Date:11/30/2015)... ... November 30, 2015 , ... The recently published 32nd Annual ... (NPDS) reveals that in 2014, someone called a poison center about every 11 ... which were human exposure cases. , The American Association of Poison Control Centers ...
Breaking Medicine News(10 mins):
(Date:11/30/2015)... Medical Systems (NYSE: VAR ) has signed a Memorandum of ... the largest hospital chain in India , to ... country. The MoU was signed by Dr. K. Prabakar , ... Varian,s India managing director, in ... intends to deploy its Access to Care program by leveraging the ...
(Date:11/30/2015)... , Nov. 30, 2015   VolitionRx Limited (NYSE ... diagnostic tests for a broad range of cancer types and ... LD Micro Conference, which will be held December 1 - 3 ... from VolitionRx will be David Kratochvil , Chief Financial ... of Investor Relations. ® blood-based tests for ...
(Date:11/30/2015)... -- Mexico Healthcare and Life Sciences Report 2015 . ... --> Pharmaboardroom releases its new 98-page Mexico Healthcare ... , a country of over 122 million people. --> ... million people. --> It offers companies, investors, policymakers, and ... into the second largest pharma and healthcare market in ...
Breaking Medicine Technology: