Navigation Links
Study suggests systemic sclerosis is an independent risk factor for atherosclerosis
Date:5/10/2011

A new study by researchers in Hong Kong suggests that systemic sclerosis is an independent determinant for moderate to severe coronary calcification or atherosclerosis. Conventional cardiovascular risk factors such as age and hypertension predispose patients with systemic sclerosis to plaque build-up in the heart arteries similar to the general population. Details of this study are now available in Arthritis & Rheumatism, a journal published by Wiley-Blackwell on behalf of the American College of Rheumatology (ACR).

Systemic sclerosis, also known as scleroderma, is a connective tissue disease which is characterized by sclerodermatous (hardening of tissue due to increased collagen deposits) skin changes, Raynaud's phenomenon, and internal organ fibrosis. The ACR estimates that systemic sclerosis affects 49,000 Americans and a prior U.S. study approximated the prevalence to be 25 per 100,000 individuals. While medical evidence suggests that coronary artery disease (CAD) is increasing in patients with systemic sclerosis, the prevalence of coronary calcification (a measure of coronary artery atherosclerosis) and its risk factors remain unknown.

In the current study a research team, led by Dr. Mo Yin Mok of the Queen Mary Hospital and the University of Hong Kong, recruited 53 patients with systemic sclerosis (50 female, 3 male) and 106 healthy controls to examine coronary artery calcium scores (CACS) and cardiovascular risk factors. Disease activity score, antiphospholipid antibodies, C-reactive protein, and erythrocyte sedimentation rate were also measured for scleroderma patients.

Researchers found that 57% of patients with systemic sclerosis had moderate to severe coronary calcification (CACS greater than 101) compared to only 29% of controls. Scleroderma patients also had significantly lower LDL-cholesterol, HDL-cholesterol, and diastolic blood pressure compared to healthy controls. In addition, compared to the control group, roughly one-third of patients had a low body mass index (BMI) and would be considered underweight according to recommended BMI cutoffs for Asian populations.

Regression analysis also showed that systemic sclerosis was an independent risk factor for coronary artery calcification (odds ratio of 10.89), and disease duration was associated with more severe atherosclerosis. The results of this study concur with previous reports of increased atherosclerosis as determined by angiography in patients with systemic sclerosis. "Our findings show that systemic sclerosis patients have an 11-fold increased risk for developing moderate to severe coronary calcification after adjustment for normal cardiovascular risk factors," concluded Dr. Mok. "CAD is a major global health concern, and further studies should explore modifiable disease-specific risk factors in scleroderma patients that could inhibit coronary calcification in this population."


'/>"/>

Contact: Dawn Peters
healthnews@wiley.com
781-388-8408
Wiley-Blackwell
Source:Eurekalert

Related medicine news :

1. Less than half of patients with MS continually adhere to drug therapies for treatment: Study
2. Study: Lowering cost doesnt increase hearing aid purchases
3. A new study on self-injury behavior encourages quick and targeted intervention
4. Study Questions Overuse of Colonoscopy in Medicare Patients
5. Ring Finger Length Linked to ALS, Study Suggests
6. S. Korean Study Suggests Autism Rate May Be Much Higher
7. Gastric Bypass May Help Prevent Heart Disease in Teens: Study
8. Study finds teens often willing to accept free or low-cost rapid HIV testing
9. Henry Ford Hospital study: Open-access colonoscopy is safe
10. Childs Head Injury Doesnt Always Need CT Scan: Study
11. Large study finds CT scans are frequently unnecessary after head injury in children
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/23/2017)... ... January 23, 2017 , ... The American Academy of ... scientific development, healthcare training and clinical application of medical infrared imaging, has announced ... Certification Qualification Courses for Technicians, respectively. , For the first time the AAT ...
(Date:1/23/2017)... ... 2017 , ... Moisture measurement is a necessary process step ... to success. Selecting an inappropriate measurement method can cause costly errors, and poor ... equipment. Rare or expensive substances are wasted and production may even be stopped ...
(Date:1/23/2017)... ... , ... Old School Labs™, makers of the wildly popular all-natural sports supplements ... to its growing team of brand ambassadors. The Olympia top finisher and former Big ... a year was able to turn professional, participating in the 2013 NPC USA Championships ...
(Date:1/23/2017)... ... ... the Mill”: a story of love and redemption, hope and uncertainty as a girl ... , “The Inn at the Mill” is the creation of published author, Lois Kulp, who ... living in Berks County on Crow Hill. The inn, the mill and "Post ...
(Date:1/23/2017)... ... January 23, 2017 , ... “Life Under Blankets”: an entrancing story ... age. “Life Under Blankets” is the creation of published author, Kimberly Mitchell, who earned ... Chicago. She went on to pursue a master’s degree in education in the field ...
Breaking Medicine News(10 mins):
(Date:1/20/2017)... Research and Markets has announced the ... and Future" report to their offering. ... This research service on the global ... and provides a snapshot of the key participants in the market. ... provided from 2016 to 2020. The market is expected to grow ...
(Date:1/19/2017)... , Jan. 19, 2017 ... Summary GlobalData,s new report, "Germany Cataract Surgery Devices ... the Germany Cataract Surgery Devices market. The report provides ... and average prices (USD) within market segements - Phacoemulsification ... also provides company shares and distribution shares data for ...
(Date:1/19/2017)... and Webcast to Follow Vanda Pharmaceuticals Inc. (Vanda) (NASDAQ: ... the fourth quarter of 2016 on Wednesday, February 15, 2017, after ... ... on Wednesday, February 15, 2017, during which management will discuss the ... activities. To participate in the conference call, please dial 1-888-771-4371 (domestic) ...
Breaking Medicine Technology: