Navigation Links
Study suggests reliability of cognitive assessment tool varies widely
Date:11/24/2008

November 24, 2008, Amsterdam, The Netherlands and Sun City, AZ, USA -- A study published in the November issue of the Journal of Alzheimer's Disease (Volume 15:3) suggests the reliability of the Alzheimer's Disease Assessment Scale Cognitive (ADAS-Cog) may vary and possess the ability to affect clinical trial outcomes.

Moreover, this study further suggests that ADAS-Cog rater training and experience are factors that contribute to variances seen in this assessment tool.

The importance of a reliable diagnosis of the Alzheimer's disease (AD) is critical as new pharmacotherapies are being developed. The ADAS-cog is considered the gold-standard and the most popular cognitive testing instrument used in clinical trials to detect changes in the core symptoms of AD.

This study critically looks at various factors that might influence the way the ADAS-cog is administered and therefore may lead to and yield unintended outcomes. The study found factors such as rater training, rater education, variance in time allotment during testing as well as rater experience and individual judgment may contribute to variance in scoring when using this assessment.

"Clinical trials for the possible treatment of Alzheimer's disease and other dementias are becoming more expansive and being run in many countries. The necessity for the primary outcome instrument to be administered consistently in different countries, cultures and between different clinical trials is critical if we are to determine which treatment works better than others. Any variability in how the instruments are administered can adversely affect the ability to detect positive outcomes," says Donald Connor PhD, PhD, director of neuropsychology at Banner Health's Sun Health Research Institute.

Rater experiences were not the only factors that contributed to variances in ADAS-cog scoring. The study also suggested that test materials changed over time including large ranges in the quality of naming materials, word card decks, instruction manuals and worksheets, all factors that can affect outcomes.

"Even as we try to develop better instruments for the detection of meaningful change we must make sure that our current instruments are utilized as effectively as possible," Dr. Connor says. "As the population continues to age rapidly and new Alzheimer's medications are being developed, it is critical that all who are involved in clinical evaluation and testing does so with precision and consistency."


'/>"/>

Contact: Astrid Engelen
a.engelen@iospress.nl
31-206-883-355
IOS Press
Source:Eurekalert

Related medicine news :

1. Study identifies double-balloon enteroscopy as cost-effective approach for obscure GI bleeding
2. Health study in northern Uganda calls for improved services for internally displaced persons
3. Pregnancy study finds strong association between two antidepressants and heart anomalies
4. Wide-Ranging Study of National News Reveals Health News Comprises Less Than Four Percent of All Coverage
5. Study of ancient and modern plagues finds common features
6. Physicians Anticipate Higher Prescribing Based on JUPITER Study
7. New Study Data: JANUVIA™ (sitagliptin) Significantly Reduced Blood Sugar Levels and Was Not Associated with Hypoglycemia in Elderly Patients with Type 2 Diabetes
8. STAAR Surgical Forms Team of Leading Ophthalmic Surgeons to Study the Use of Collamer(R) Material for Accommodating Intraocular Lenses
9. Landmark study defines benefits of early HIV testing and treatment for infected infants
10. Study identifies causes of bone loss in breast cancer survivors
11. New Study by BioTrends Highlights Practice Management Shifts Among Canadian Nephrologists
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/24/2017)... ... May 24, 2017 , ... ... ExtraHop to its solutions portfolio. ExtraHop delivers an analytics-first approach, layered with machine ... IT system, from the datacenter to the cloud to the edge. Through the ...
(Date:5/24/2017)... ... May 24, 2017 , ... ... pediatric dentistry options for its patients on Long Island, New York. , ... well being, and is one of the biggest trends in dentistry today. ...
(Date:5/24/2017)... IL (PRWEB) , ... May 24, 2017 , ... ... the most prominent for-profit and nonprofit hospitals and health systems in the nation ... turned around their institutions, led professional organizations and been instrumental in developing successful ...
(Date:5/24/2017)... ... May 24, 2017 , ... Technique, technique, technique – with a ... lifting weights for strength training and exercise or simply lifting heavy objects, advises Dr. ... position is everything,” Dr. Chang says. “Improper technique in lifting anything heavy or an ...
(Date:5/23/2017)... ... May 23, 2017 , ... ... Clinical Integration company, announced today that its iClinic V12.2 solution has achieved approval ... NCQA recently introduced PCMH 2017 standards which emphasize team-based care with a ...
Breaking Medicine News(10 mins):
(Date:5/8/2017)... 8, 2017 MACRA replaces the outdated ... for service reimbursement. Black Book Research crowdsource-surveyed 8,845 physician ... 1.       The Market for MIPS Compliance Technology is Booming ... practices with 3 or more clinicians seek to buy ... "Given the magnitude of the changes, the hunt is ...
(Date:5/6/2017)... IRVING, Texas , May 5, 2017   Provista ... 1994 with more than 200,000 customers, today announced Jim ... brings a wealth of executive and business experience to Provista, ... a compounding pharmacy in California . He ... "Jim is a great fit for Provista," says ...
(Date:5/6/2017)... 5, 2017  Hill-Rom Holdings, Inc. (NYSE: HRC), has ... square feet to its Welch Allyn campus. ... to bring more than 100 new jobs to ... has maintained a significant presence for more than 100 ... positions, a large portion of which will be R&D ...
Breaking Medicine Technology: