Navigation Links
Study suggests reduced lung function in infancy associated with wheeze later
Date:2/18/2013

A study in Australia suggests that reduced lung function in infancy was associated with wheezing beyond childhood at 18 years of age, according to a report published Online First by JAMA Pediatrics, a JAMA Network publication.

Abnormal airway function is characteristic of asthma and chronic obstructive airways disease, and other studies have suggested that reduced lung function is already apparent in childhood and tracks through adulthood. However, the relationship between the age of onset of airway dysfunction and wheeze, a symptom of obstructive airways disease, has not been clarified, the authors write in the study background.

The study by David Mullane, M.D., of University College Cork, Ireland, and colleagues included participants from a birth cohort who had been followed from one month to 18 years. At age 18 years, 150 participants were assessed and 37 participants (25 percent) had recent wheeze and 20 (13 percent) were diagnosed with asthma, according to the results.

"To our knowledge, this study is the first to report an association between reduced lung function in infancy and wheeze beyond childhood," the authors note.

In the study, a total of 143 participants were categorized as having persistent wheeze (n=13), later-onset wheeze (n=19), remittent wheeze (n=15) and no wheeze (n=96). Compared with the no-wheeze group, persistent wheeze was independently associated with reduced percentage of predicted maximal flow at functional residual capacity (V'maxFRC, mean reduction 43 percent). Compared with the no-wheeze group, persistent wheeze was also associated with atopy (a predisposition to allergic reactions) in infancy (odds ratio, 7.1); maternal asthma (odds ratio, 6.8) and active smoking (odds ratio, 4.8), according to the results.

"Unexpectedly, we observed that a reduced V'maxFRC at age one month was associated with increased risk for wheeze only in young adults who were also current smokers. These results suggest that reduced early airway function and later exposures such as smoking are important to the cause of obstructive respiratory diseases in young adults. Interventions aimed at preventing young children with asthma symptoms and reduced lung function from smoking might prevent persisting symptoms of obstructive airways disease," the authors comment. (JAMA Pediatr. Published online February 18, 2013. doi:10.1001/jamapediatrics.2013.633. Available pre-embargo to the media at http://media.jamanetwork.com.)

Editor's Note: This work was supported by the National Medical and Health Research Council of Australia. Please see the article for additional information, including other authors, author contributions and affiliations, financial disclosures, funding and support, etc.

Editorial: Neonatal Lung Function, Later Consequences

In a related editorial, Kai-Hkon Carlsen, M.D., Ph.D., of Oslo University Hospital, Norway, writes: "Mullane and colleagues present the results from an 18-year follow-up of a birth cohort recruited in Perth, Western Australia, during the late 1980s."

"The study by Mullane et al in the present issue of JAMA Pediatrics gives additional evidence to the finding that reduced lung function in early life has an important impact on later respiratory health. Taken together with the other studies cited, we may perhaps take away the message from the statement by Burrows and Taussig: 'As the twig is bent, the tree inclines.'"

(JAMA Pediatr. Published online February 18, 2013. doi:10.1001/jamapediatrics.2013.119. Available pre-embargo to the media at http://media.jamanetwork.com.)

Editor's Note: Please see the article for additional information, including other authors, author contributions and affiliations, financial disclosures, funding and support, etc.


'/>"/>
Contact: Steve W. Turner, M.D.
s.w.turner@abdn.ac.uk
JAMA and Archives Journals
Source:Eurekalert

Related medicine news :

1. Doctors fail to communicate impact of heart devices with patients, SLU study finds
2. U.S. Plans Billion-Dollar Project to Study the Brain
3. Women at Greater Risk for Hip Implant Failure, Study Finds
4. New study on Hepatitis C drug treatment in vivo and in vitro
5. Smoggy Air Tied to Heart Attacks: Study
6. Proscar Wont Boost Prostate Cancer Survival, Study Finds
7. Bel Marra Health Reports on a New Study: Body Image Influences Psychosocial Activities and Quality of Life.
8. New Study Finds Eating More Colorful Produce May Prevent or Delay ALS, Underscores Value of Health Enhancement Systems Program Design
9. MRSA Super Bug Prevalent in Nursing Homes, Study Finds
10. Study finds possible link between diabetes and increased risk of heart attack death
11. Rich/Poor Divide Linked to Hospital Readmissions in Study
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/25/2016)... ... June 25, 2016 , ... "With 30 hand-drawn hand gesture animations, FCPX ... Austin - CEO of Pixel Film Studios. , ProHand Cartoon’s package transforms over ... Cut Pro X . Simply select a ProHand generator and drag it above media ...
(Date:6/25/2016)... ... ... Friday, June 10, Van Mitchell, Secretary of the Maryland Department of Health and Mental ... exemplary accomplishments in worksite health promotion. , The Wellness at Work Awards took place ... BWI Marriott in Linthicum Heights. iHire was one of 42 businesses to receive an ...
(Date:6/24/2016)... ... June 24, 2016 , ... June 19, 2016 is World Sickle Cell Observance ... and the benefits of holistic treatments, Serenity Recovery Center of Marne, Michigan, ... Disease. , Sickle Cell Disease (SCD) is a disorder of the red blood cells, ...
(Date:6/24/2016)... San Francisco, CA (PRWEB) , ... June 24, ... ... at CitiDent, is now offering micro-osteoperforation for accelerated orthodontic treatment. Dr. Cheng has ... , self-ligating Damon brackets , AcceleDent, and accelerated osteogenic orthodontics. , ...
(Date:6/24/2016)... Norcross, Georgia (PRWEB) , ... June 24, 2016 ... ... Year” awards today at the Clinical Decision Making in Emergency Medicine conference in ... who have authored journal articles published in Emergency Medicine Practice and ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... 23, 2016 Research and Markets ... Market by Type (Organic Chemical (Sugar, Petrochemical, Glycerin), Inorganic ... Coating, Parenteral) - Global Forecast to 2021" report ... The global pharmaceutical excipients market is projected to ... of 6.1% in the forecast period 2016 to 2021. ...
(Date:6/23/2016)... ANGELES , June 23, 2016 ... CAPR ), a biotechnology company focused ... therapeutics, today announced that patient enrollment in its ... in Duchenne) has exceeded 50% of its 24-patient ... enrollment in the third quarter of 2016, and ...
(Date:6/23/2016)... INDIANAPOLIS , June 23, 2016 If ... Leaders Scholarship is any indication, the future is in ... at www.diabetesscholars.org by the Diabetes Scholars Foundation ... the way of academic and community service excellence. ... since 2012, and continues to advocate for people with ...
Breaking Medicine Technology: