Navigation Links
Study suggests nicotine addiction might be controlled by influencing brain mechanisms
Date:12/8/2007

Boca Raton, FL, December 8, 2007 There is a clear link between GABA a chemical substance of the central nervous system that inhibits neurons in the brain and nicotine dependence, according to a study presented today at the American College of Neuropsychopharmacology (ACNP) annual meeting. Researchers discovered that nicotine has significant effects on brain GABA, a finding which could potentially help curb the pleasurable effects of nicotine and help people break their addiction to it.

We found that GABA may provide a very useful target for nicotine addiction therapies, said Graeme Mason, Ph.D., associate professor in the Magnetic Resonance Research Center in the Departments of Diagnostic Radiology and Psychiatry at Yale University School of Medicine and an ACNP member. GABA is just one of a complex network of actors that promotes addiction, and were hoping that this research will ultimately lead us to ways to help people quit smoking.

Mason sought to discover whether the enjoyable effects associated with smoking could be reduced in some way. When people use nicotine they may experience a sensation of reward, diminished anxiety, or a belief that they can focus more clearly or learn more easily. Researchers wanted to explore how a specific type of neuron that releases dopamine, a chemical that has been associated with pleasure, can prolong and intensify the pleasurable effects of nicotine. Although GABA inhibits those neurons, nicotine works against the ability of GABA to inhibit dopamine neurons after about 20 minutes, so the gratifying effects of nicotine are prolonged.

Researchers gave people who smoked regularly nicotine inhalers that deliver the same amount of the drug as in one cigarette. The amount of GABA in the subjects brains rose about 10%, but the brain was found to make GABA four times faster after using the inhalers, and the rate of new GABA generation remained high for at least 45 minutes. In other words, keeping the supply of GABA levels high has the potential to reduce the pleasurable effects of smoking, in terms of duration and intensity.

While GABA is probably not the root of nicotine addiction, it is part of a complex network of actors that are involved in addiction, Mason says.

Another study presented at the ACNP annual meeting which explored the role of GABA, genetics and environmental factors in smoking found that tobacco addiction is at least 50% determined by genetics. For this reason, researchers may be able to identify individuals who are vulnerable to nicotine dependence, and then implement prevention strategies accordingly.

For this study, Ming Li, Ph.D., Professor of Genetics in Psychiatry and Neurosciences at the University of Virginia recruited more than 2000 participants representing more than 600 families of smokers. They examined different regions on various chromosomes that showed linkage to nicotine addiction. Then they searched for susceptibility genes within these regions that appear to be associated with addiction. Some of these are the GABA-B receptor subunit 2 (GABAB2) gene on chromosome 9, and the GABA-A receptor-associated protein (GABARAP) gene on chromosome 17.

Li says the research could have significant public health implications because it could help curb smoking rates since researchers may be able to predict who is more prone to nicotine addiction. Tobacco is one of the most widely used substances; it kills more than 435,000 Americans each year, and despite increasing public awareness of the health risks associated with its use, little reduction in smoking prevalence has been achieved nationwide in recent years.


'/>"/>

Contact: Sharon Reis
sreis@gymr.com
202-745-5103
American College of Neuropsychopharmacology
Source:Eurekalert

Related medicine news :

1. Penn study finds pro-death proteins required to regulate healthy immune function
2. New study shows promise in reducing surgical risks associated with surgical bleeding
3. Study, meta-analysis examine factors associated with death from heatstroke
4. Study suggests loss of 2 types of neurons -- not just 1 -- triggers Parkinsons symptoms
5. Study says COPD testing is not measuring up
6. Preclinical study suggests organ-transplant drug may aid in lupus fight
7. Ability to cope with stress can increase good cholesterol in older white men, study finds
8. High alcohol consumption increases stroke risk, Tulane study says
9. Mailman School of Public Health study examines link between racial discrimination and substance use
10. Pitt study finds inequality in tobacco advertising
11. Stanford study highlights cost-effective method of lowering heart disease risks
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/12/2017)... ... October 12, 2017 , ... HMP , a leader in ... 2017 Folio Magazine Eddie Digital Award for ‘Best B-to-B Healthcare Website.’ Winners were announced ... 2017. , The annual award competition recognizes editorial and design excellence across a range ...
(Date:10/12/2017)... FL (PRWEB) , ... October 12, 2017 , ... On ... holding a treadmill relay – Miles by Moonlight to raise money for the American ... $300 or more. , Teams will work together to keep their treadmills moving ...
(Date:10/12/2017)... ... 12, 2017 , ... Health Literacy Innovations (HLI), creator of ... and the Cancer Patient Education Network (CPEN), an independent professional organization that shares ... strategic alliance. , As CPEN’s strategic partner, HLI will help support CPEN ...
(Date:10/12/2017)... ... 2017 , ... Vohra Chief Medical Officer Dr. Shark Bird, ... nursing facility medical directors and other clinicians at various events in October. His ... many of these conferences we get to educate other physicians, facility nurses, corporate ...
(Date:10/12/2017)... ... October 12, 2017 , ... ... enhanced Pepper Flow promotional review platform at the Promotional Review Committee Compliance ... capabilities help marketers streamline the medical, legal, and regulatory review (MLR) process ...
Breaking Medicine News(10 mins):
(Date:10/11/2017)... Oct. 11, 2017  Caris Life Sciences ® , ... the promise of precision medicine, today announced that St. ... Precision Oncology Alliance™ (POA) as its 17 th ... St. Jude Crosson Cancer Institute will help develop standards ... of tumor profiling, making cancer treatment more precise and ...
(Date:10/10/2017)... Calif. , Oct. 10, 2017  NDS received FDA 510(k) ... — a medical-grade battery-powered display stand specifically designed for endoscopy environments. ... transform technology into a clinical solution to support the improvement of ... Innovative Design ... Mobile Wireless Solution ...
(Date:10/5/2017)... Ill. , Oct. 5, 2017  In ... Association of Oral and Maxillofacial Surgeons (AAOMS) released ... opioids – to be used as a first-line ... pain. Recognizing ... the AAOMS White Paper "Opioid Prescribing: Acute and ...
Breaking Medicine Technology: