Navigation Links
Study suggests new therapy for lung disease patients

CHICAGO -- A new study by researchers at Northwestern University's Feinberg School of Medicine may change current thinking about how best to treat patients in respiratory distress in hospital intensive care units.

It has been commonly believed that high levels of carbon dioxide (CO2) or hypercapnia in the blood and lungs of patients with acute lung disease may be beneficial to them. Now, for the first time, scientists have shown how elevated levels of CO2 actually have the opposite effect.

The excessive CO2 impairs the functioning of the lungs. Jacob Sznajder, M.D., chief of pulmonary and critical care at the Feinberg School, and his research team found that high levels of CO2 make it harder for the lungs to clear fluid.

The excess CO2 initiates a signaling cascade leading to the inhibition of the action of sodium pumps that help move water out of the air spaces. This creates a greater risk of edema in which the lungs flood with fluid.

The investigators worked with rats and human cells for the study, which was published in the February issue of the Journal of Clinical Investigation.

"Allowing high levels of CO2 may contribute to the high mortality of patients with diseases like chronic obstructive pulmonary disease (COPD)," said Sznajder, a professor of medicine and of cell and molecular biology at the Feinberg School and a physician at Northwestern Memorial Hospital. "This study argues toward therapies to reduce the high CO2 levels of patients toward normal levels, which is not the current practice in the intensive care unit."

COPD is the fourth leading cause of death in the United States, killing more than 120,000 people, according to the National Institutes of Health. When people have COPD, their lungs lose elasticity and have trouble exchanging carbon dioxide for oxygen. COPD used to be strictly a disease of smokers, but now it's also crippling the lungs of non-smokers.


Contact: Marla Paul
Northwestern University

Page: 1

Related medicine news :

1. CyberKnife Centers of Miami, Palm Beach and Tampa Invited to Join M.D. Anderson Cancer Center Study
2. Looking for a Career? A New Study Shows Demand for Doctors of Podiatric Medicine to Surge Over the Next Six Years
3. Bone complications due to cystic fibrosis have a genetic cause, according to an MUHC study
4. UTMB wins $3.4 million federal grant to study addiction-recovery drugs
5. Meningitis vaccine study gets £200,000 boost
6. Baby Bottles Leach Toxic Chemical, According to New U.S. and Canadian Study
7. Aggressive Diabetes Therapy Lowers Death Risk, Study Finds
8. Impact of electronic personal health record on hypertension under study
9. Treating acne: 2 different acid peels are both effective, study finds
10. New study suggests link between environmental toxins and early onset puberty in girls
11. Nile Therapeutics Announces Dosing of First Heart Failure Patient in Phase Ib Study of CD-NP
Post Your Comments:
(Date:11/25/2015)... ALTO, Calif. (PRWEB) , ... November 25, 2015 , ... ... Smart and Beddit Classic sleep tracking systems. The new app features a more intuitive ... see and understand how well you slept. The SleepScore is created by a proprietary ...
(Date:11/25/2015)... LOUIS, Missouri (PRWEB) , ... November 25, 2015 ... ... Project HEAL, will provide scholarships for people struggling with eating disorders as a ... Proceeds from the second annual event, held at Fox Run Golf Club in ...
(Date:11/25/2015)... ... November 25, 2015 , ... Many people know of the common ... cold hands, and dry skin. But many people who find their cholesterol levels and ... instead of their thyroid, especially if they don’t have any of the other symptoms. ...
(Date:11/24/2015)... ... November 25, 2015 , ... ... Their Care Plan software creates an agreement between the practice owner and ... including financial, scheduling, monitoring, notification, and projections. Click here to ...
(Date:11/24/2015)... Texas (PRWEB) , ... November 24, 2015 , ... Charitable ... all charitable donations are made in the last five weeks of the year totalling ... was created in 2012 to connect the nation’s charities with those individuals who want ...
Breaking Medicine News(10 mins):
(Date:11/25/2015)... SAN DIEGO , Nov. 25, 2015  Trovagene, ... molecular diagnostics, today announced that Chief Executive Officer Antonius ... at the 27 th Annual Piper Jaffray Healthcare ... Conference at the New York Palace Hotel in ... 2015 at 1:30 p.m. EST. Mr. Schuh will be ...
(Date:11/25/2015)... Endo International plc (NASDAQ: ENDP ) (TSX: ... and CEO, will discuss corporate updates at the 27 th ... York on Wednesday, December 2, 2015 at 1 ... Relations, and then the link to the event. Participants should ... to visit the site and download any streaming media software ...
(Date:11/25/2015)... Israel , November 25, 2015 ... "New Investors"), pursuant to which BioLight and the New ... IOPtima Ltd. subsidiary ("IOPtima") via a private placement. The ... of its innovative IOPtimate™ system used in the treatment ... approval pathway process for the IOPtimate™ system with the ...
Breaking Medicine Technology: