Navigation Links
Study suggests new therapy for lung disease patients
Date:2/7/2008

CHICAGO -- A new study by researchers at Northwestern University's Feinberg School of Medicine may change current thinking about how best to treat patients in respiratory distress in hospital intensive care units.

It has been commonly believed that high levels of carbon dioxide (CO2) or hypercapnia in the blood and lungs of patients with acute lung disease may be beneficial to them. Now, for the first time, scientists have shown how elevated levels of CO2 actually have the opposite effect.

The excessive CO2 impairs the functioning of the lungs. Jacob Sznajder, M.D., chief of pulmonary and critical care at the Feinberg School, and his research team found that high levels of CO2 make it harder for the lungs to clear fluid.

The excess CO2 initiates a signaling cascade leading to the inhibition of the action of sodium pumps that help move water out of the air spaces. This creates a greater risk of edema in which the lungs flood with fluid.

The investigators worked with rats and human cells for the study, which was published in the February issue of the Journal of Clinical Investigation.

"Allowing high levels of CO2 may contribute to the high mortality of patients with diseases like chronic obstructive pulmonary disease (COPD)," said Sznajder, a professor of medicine and of cell and molecular biology at the Feinberg School and a physician at Northwestern Memorial Hospital. "This study argues toward therapies to reduce the high CO2 levels of patients toward normal levels, which is not the current practice in the intensive care unit."

COPD is the fourth leading cause of death in the United States, killing more than 120,000 people, according to the National Institutes of Health. When people have COPD, their lungs lose elasticity and have trouble exchanging carbon dioxide for oxygen. COPD used to be strictly a disease of smokers, but now it's also crippling the lungs of non-smokers.


'/>"/>

Contact: Marla Paul
Marla-Paul@northwestern.edu
312-503-8928
Northwestern University
Source:Eurekalert

Page: 1

Related medicine news :

1. CyberKnife Centers of Miami, Palm Beach and Tampa Invited to Join M.D. Anderson Cancer Center Study
2. Looking for a Career? A New Study Shows Demand for Doctors of Podiatric Medicine to Surge Over the Next Six Years
3. Bone complications due to cystic fibrosis have a genetic cause, according to an MUHC study
4. UTMB wins $3.4 million federal grant to study addiction-recovery drugs
5. Meningitis vaccine study gets £200,000 boost
6. Baby Bottles Leach Toxic Chemical, According to New U.S. and Canadian Study
7. Aggressive Diabetes Therapy Lowers Death Risk, Study Finds
8. Impact of electronic personal health record on hypertension under study
9. Treating acne: 2 different acid peels are both effective, study finds
10. New study suggests link between environmental toxins and early onset puberty in girls
11. Nile Therapeutics Announces Dosing of First Heart Failure Patient in Phase Ib Study of CD-NP
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2017)... ... 22, 2017 , ... Phytocéane invites clients to take an exotic journey deep ... with ZANZIBAR MILKY CREAM. Inspired by the beauty of Zanzibar, a Tanzanian archipelago off ... moisturizing vegetal coral to create this gentle, velvety body cream to envelop the skin ...
(Date:1/22/2017)... , ... January 22, 2017 , ... Medical lab ... results. Often the results of a simple test will take days to arrive to ... Test Now offers customers direct access to their lab tests, bypassing the cost and ...
(Date:1/21/2017)... ... 2017 , ... "ProDOF is the perfect set of tools for video editors that want to ... said Christina Austin - CEO of Pixel Film Studios. , Video editors using ProDOF ... of a DSLR racking focus from one area into the next. ProDOF comes with ...
(Date:1/21/2017)... Barbara, CA (PRWEB) , ... January 21, 2017 ... ... its Director of Alumni Relations, Dianne Travis-Teague, the electrifying line-up of events for ... festivities for alumni, family, friends, and community. “Coming Home 2017” will be ...
(Date:1/21/2017)... (PRWEB) , ... January 21, 2017 , ... In the ... when individuals experience the freedom of recovery, they often feel shame for having struggled ... post-traumatic stress disorder (PTSD). In the workshop, “Rising Strong in Life After an Eating ...
Breaking Medicine News(10 mins):
(Date:1/23/2017)... , Jan. 23, 2017  Using Astute Medical,s ... high risk for acute kidney injury (AKI) after ... globally-recognized care guidelines significantly improved outcomes ... AKI more than 33 percent, according to a ... journal Intensive Care Medicine. ...
(Date:1/23/2017)... Longer life expectancy and rising healthcare expenditure in developing countries are factors ... BCC Research reveals in its new report that markets in developing ... strong growth due to rising government healthcare spending, increased levels of healthcare ... Reading ... BCC ...
(Date:1/23/2017)... 2017 NeuroVive Pharmaceutical AB (Nasdaq Stockholm: ... preclinical collaboration agreement with the Children,s Hospital of ... M.D., a US key opinion leader in the mitochondrial medicine ... ... from NeuroVive,s research program, NVP015, in certain experimental disease models. ...
Breaking Medicine Technology: