Navigation Links
Study suggests new source of kidneys for transplant
Date:5/20/2013

WINSTON-SALEM, N.C. May 20, 2013 Nearly 20 percent of kidneys that are recovered from deceased donors in the U.S. are refused for transplant due to factors ranging from scarring in small blood vessels of the kidney's filtering units to the organ going too long without blood or oxygen. But, what if instead of being discarded, these organs could be "recycled" to help solve the critical shortage of donor organs?

Researchers at Wake Forest Baptist Medical Center and colleagues, reporting in the journal Biomaterials, found that human kidneys discarded for transplant can potentially serve as a natural "scaffolding material" for manufacturing replacement organs in the lab using regenerative medicine techniques.

According to the authors, more than 2,600 donor kidneys are discarded each year in the U.S. "With about 100,000 people in the U.S. awaiting kidney transplants, it is devastating when an organ is donated but cannot be used," said Giuseppe Orlando, M.D., Ph.D., lead author, a Wake Forest Baptist transplant surgeon and regenerative medicine researcher. "These discarded organs may represent an ideal platform for investigations aimed at manufacturing kidneys for transplant."

The research involved pumping a mild detergent through kidneys that were refused for transplant. The goal of the process, called decellularization, is to remove all cells leaving only the organ structure or "skeleton," known in regenerative medicine terms as a scaffold. Ultimately, the patient's own cells could be placed in this scaffold, creating a customized organ that the patient theoretically would not reject.

In fact, an analysis of the decellularized organs revealed that antigens likely to cause an immune response were removed in the cleaning process. "This finding has significant implications," said Orlando. "It indicates that transplantation of such customized kidneys could be performed without the need for anti-rejection therapy. In addit
'/>"/>

Contact: Karen Richardson
krchrdsn@wakehealth.edu
336-716-4453
Wake Forest Baptist Medical Center
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Metal-on-Metal Hip Replacement Lawyers Note New Study Finding MRIs Can Be Used to Predict Metal-on-Metal Hip Implant Failure
2. Nighttime Docs at ICUs Dont Boost Patient Outcomes: Study
3. Study: Older Whooping Cough Vaccine More Effective
4. Study supports aggressive treatment for posterior fossa hematoma in newborns
5. Hospital emergency departments gaining in importance, study finds
6. 1 in 10 teens using study drugs, but parents arent paying attention
7. New study finds blind people have the potential to use their inner bat to locate objects
8. Women Less Likely to Get Trauma Center Care After Injury: Study
9. Atherosclerotic disease heredity mapped in nationwide study
10. New study suggests candy consumption frequency not linked to obesity or heart disease
11. Sleep Apnea in Seniors Tied to Alzheimers in Study
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/17/2014)... in the April issue of Immunity , Kevin ... Medical Research, says it,s time to take a fresh ... sepsis, which kills millions worldwide every year, including ... released into the bloodstream to fight an injury or ... for maintaining good health without inflammation, wounds and ...
(Date:4/17/2014)... A Northwestern University synthetic biology team has created ... create programmable therapeutics that could travel the body ... disease. , Engineering cell-based, biological devices that monitor ... in clinical synthetic biology. However, no existing technology ... a patient,s physiological state and respond in a ...
(Date:4/17/2014)... Doctors who treat patients with a severe and ... an agonizing treatment decision. , The drug sirolimus ... relieve shortness of breath. But some patients eventually ... potentially fatal complications following transplantation. , "It,s a ... director of Loyola University Medical Center,s LAM Clinic ...
(Date:4/17/2014)... YORK, NY (April 16, 2014) The cause of ... a new study proposes that neurons may be mistaken ... immune system, similar to the way autoimmune diseases like ... the body,s cells. The study was published April 16, ... a new, and likely controversial, idea in Parkinson,s disease; ...
(Date:4/17/2014)... April 17, 2014 By discovering a new mechanism ... a stroke, researchers at UC Irvine and the Salk ... may limit or prevent stroke-induced brain damage. , A ... cause of death and primary reason for disability in ... a stroke and lets blood-borne material into the brain, ...
Breaking Medicine News(10 mins):Health News:Feinstein Institute researcher publishes new perspective on sepsis 2Health News:Building 'smart' cell-based therapies 2Health News:Patients with rare lung disease face agonizing treatment dilemma 2Health News:Patients with rare lung disease face agonizing treatment dilemma 3Health News:Is Parkinson's an autoimmune disease? 2Health News:Study IDs new cause of brain bleeding immediately after stroke 2
... An apple a day keeps the doctor away, yes; ... disease away as well//. Apple and apple juice were ... manner as medicines by researchers from the University of ... apple juice might increase the production in the brain ...
... Three years after the Centre for Science and Environment ... and a joint parliamentary committee endorsed it later// , ... again in 11 brands. ,Addressing a press conference ... by their pollution-monitoring laboratory has found pesticides in soft ...
... nutrition may be the best way to eat a lot during ... dietary details of about 7500, adults, researchers found that those who ... a larger quantity of food than those who consumed rich food. ... calorie count was much less than those who ate richer food. ...
... of people in UK expose themselves to the rays of the ... among cancer experts, who are rather troubled by this cream-free attitude.// ... and a record high temperature in July, it would indeed pay ... ,The trend is also because nearly 58% of the people do ...
... marijuana at the time of conception or in early ... to a new study in mice.// ,The author ... of pediatrics, cell and developmental biology and pharmacology at ... August issue of the Journal of Clinical Investigation. The ...
... of Tsunami 2004 is still fresh in the memory. There ... which ‘preparedness in adequate measure’ is considered extremely crucial.// It ... extended this sentiment in evolving suitable strategies against a potential ... German scientists will begin the exercise of delving into the ...
Cached Medicine News:Health News:Apple Juice May Keep Alzheimer's Away 2Health News:Marijuana Use Can Compromise Pregnancy 2
(Date:1/15/2014)... , Jan. 15, 2014 Reportlinker.com announces ... available in its catalogue: ... Drug Delivery Systems -- Focus on End ... STUDY OBJECTIVES A drug ...
(Date:1/15/2014)... 15, 2014  A novel wearable injector slightly larger than an ... patients to self-inject prescription drugs in the large doses required ... diseases, autoimmune deficiencies, and genetic disorders.  An ... by 2018, according to analysts.   Many of these drugs will ...
(Date:1/14/2014)... 14, 2014 InformEx, North America,s ... chemistry, will hold the 30 th edition of its ... Convention Center from January 21-24. (Logo: http://photos.prnewswire.com/prnh/20131028/NY05330LOGO-a ... pharmaceutical, fine chemical and specialty chemical companies will take part ...
Breaking Medicine Technology:Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 2Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 3Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 4Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 5Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 6Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 7Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 8Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 9Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 10Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 11Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 12Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 13Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 14Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 15Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 16Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 17Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 18Enable Injections Presents A New Class of Injectors for Drug Delivery at PEPTalk, Drug Delivery Partnership Meetings 2Media Advisory: InformEx 2014 Events & Speaker Lineup for 30th Edition Conference in Miami Beach 2
... NUREMBERG, Germany, October 13 The German ... Mobile C-arms Business,Development Strategy Leadership Award" from the independent ... successful growth strategy,of the technology leader in the area ... up of important new markets, as well as the,securing ...
... WALTHAM, Mass., Oct. 13 According to Millennium Research ... intelligence, sustained economic growth since 2003 in Brazil, Russia, ... health care expenditures with an astounding $500 billion spent ... to diagnostic imaging scanners. Findings from MRG,s newest series ...
Cached Medicine Technology:Award-Winning Medical Technology From Germany 2Award-Winning Medical Technology From Germany 3$500 Billion Health Care Spend Boosts BRIC Countries' Diagnostic Imaging Sales Despite Global Recession, According to Millennium Research Group 2$500 Billion Health Care Spend Boosts BRIC Countries' Diagnostic Imaging Sales Despite Global Recession, According to Millennium Research Group 3
... newest member of the Xpect family, Xpect C. ... B in one rapid test. The simple-to-perform test ... in 20 minutes. ,The Remel Xpect family of ... of rapid, direct specimen tests that combine exceptional ...
Compact tray features all components for urethral catheterization....
... the Integrated Cytometry Solution offers a ... coupled with complete LIS connectivity. By ... sample undergoes - and managing the ... it delivers a progressive automated system ...
Convective Air Warming Blankets...
Medicine Products: